Cavitation Bubble Cluster Activity in the Breakage of Kidney Stones by Lithotripter Shockwaves

Pishchalnikov, Yuri A.; Sapozhnikov, Oleg A.; Bailey, Michael R.; Williams, James C.; Cleveland, Robin O.; Colonius, Tim; Crum, Lawrence A.; Evan, Andrew P.; McAteer, James A.

doi:10.1089/089277903769013568

Cited by 200 publications

(133 citation statements)

References 57 publications

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“…[5][6][7][8] On the other hand, erosion by such cavitation bubbles was also reported to be an important factor. [9][10][11][12][13] The use of high-intensity focused ultrasound (HIFU) is a noninvasive treatment in which ultrasound energy is generated outside the body and focused onto the target tissue. In the focal region, acoustic cavitation bubbles are generated by an intense negative-pressure ultrasound.…”

Section: Introductionmentioning

confidence: 99%

Effect of annular focusing of ultrasound on rate of stone erosion using cavitation bubbles

Yura

Lafond

Yoshizawa

et al. 2018

Jpn. J. Appl. Phys.

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Shock wave lithotripsy has been one of the first-line treatments to fragment kidney stones. One disadvantage of this method is that some residual stone fragments can be too large to pass through the ureters. Stone fragments can be made small enough by ultrasonically induced cavitation erosion, but the erosion rate, with conventional single-spot focusing, tends to be low owing to ultrasound attenuation by excessively generated cavitation bubbles upstream of the stone surface. Sector vortex annular focusing can generate cavitation bubbles widely and thinly. We propose exposure sequences utilizing this focusing scheme and investigated their effect on erosion rate using a stone model. Sector vortex annular focusing showed an erosion rate significantly higher than that of single-spot focusing. Among them, switching between the two focusing schemes provided the highest rate, higher than the mathematical sum of those of the two schemes, and even higher than that of sector vortex focusing at the same pulse repetition.

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Section: Introductionmentioning

confidence: 99%

Effect of annular focusing of ultrasound on rate of stone erosion using cavitation bubbles

Yura

Lafond

Yoshizawa

et al. 2018

Jpn. J. Appl. Phys.

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“…2,[19][20][21] Cavitation clouds generated using focused ultrasound have been observed to form transiently in water with CW sonication at 2.5 MHz by Willard 17 and at 1 MHz by Neppiras and Coakley. 18 More recently, Sankin and Teslenko 20 have generated cavitation clouds in distilled water using a strong lithotripter a) Author to whom correspondence should be addressed.…”

Section: Introductionmentioning

confidence: 99%

Cavitation clouds created by shock scattering from bubbles during histotripsy

Maxwell

Wang

Cain

et al. 2011

The Journal of the Acoustical Society of America

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277

258

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Histotripsy is a therapy that focuses short-duration, high-amplitude pulses of ultrasound to incite a localized cavitation cloud that mechanically breaks down tissue. To investigate the mechanism of cloud formation, high-speed photography was used to observe clouds generated during single histotripsy pulses. Pulses of 5À20 cycles duration were applied to a transparent tissue phantom by a 1-MHz spherically focused transducer. Clouds initiated from single cavitation bubbles that formed during the initial cycles of the pulse, and grew along the acoustic axis opposite the propagation direction. Based on these observations, we hypothesized that clouds form as a result of large negative pressure generated by the backscattering of shockwaves from a single bubble. The positive-pressure phase of the wave inverts upon scattering and superimposes on the incident negativepressure phase to create this negative pressure and cavitation. The process repeats with each cycle of the incident wave, and the bubble cloud elongates toward the transducer. Finite-amplitude propagation distorts the incident wave such that the peak-positive pressure is much greater than the peak-negative pressure, which exaggerates the effect. The hypothesis was tested with two modified incident waves that maintained negative pressure but reduced the positive pressure amplitude. These waves suppressed cloud formation which supported the hypothesis.

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“…20 However, the extreme conditions of lithotripsy require consideration of liquid compressibility, cluster dynamics, and aspherical bubble deformation. While liquid compressibility corrections and dynamics of clusters containing arbitrary numbers of bubbles and particles are reported elsewhere, 21 the discussion here is limited for simplicity to a system with a single bubble and single particle under conditions where the liquid may be assumed incompressible.…”

Section: Introductionmentioning

confidence: 99%

Model of coupled pulsation and translation of a gas bubble and rigid particle

Hay

Hamilton

Ilinskii

et al. 2009

The Journal of the Acoustical Society of America

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A model of the interaction of a spherical gas bubble and a rigid spherical particle is derived as a coupled system of second-order differential equations using Lagrangian mechanics. The model accounts for pulsation and translation of the bubble as well as translation of the particle in an infinite, incompressible liquid. The model derived here is accurate to order R 5 / d 5 , where R is a characteristic radius and d is the separation distance between the bubble and particle. This order is the minimum accuracy required to account for the interaction of the bubble and particle. Dependence on the size and density of the particle is demonstrated through numerical integration of the dynamical equations for both the free and forced response of the system. Numerical results are presented for models accurate to orders higher than R 5 / d 5 to demonstrate the consequences of truncating the equations at order R 5 / d 5 .

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Cavitation Bubble Cluster Activity in the Breakage of Kidney Stones by Lithotripter Shockwaves

Abstract: Cavitation-mediated damage to stones is attributable, not to the action of solitary bubbles, but to the growth and collapse of bubble clusters.

Cited by 200 publications

References 57 publications

Effect of annular focusing of ultrasound on rate of stone erosion using cavitation bubbles

Effect of annular focusing of ultrasound on rate of stone erosion using cavitation bubbles

Cavitation clouds created by shock scattering from bubbles during histotripsy

Model of coupled pulsation and translation of a gas bubble and rigid particle

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