Separation of gas-borne particles by a single bubble is the physical basis of bubble scrubbing in industries. In this work, detailed, high-resolution numerical simulations have been performed on the purification process based on a combined volume-of-fluid−discrete phase model (VOF− DPM) method. Formation and rise of a single bubble over a wide range of Reynolds number (850 < Re < 5000) coupled with internal particle transport are studied. Results show that 5−7 mm bubble (1200 < Re < 1600) evidently deforms, and particle collection efficiency η is rather higher within the range. Emphasis is put on the investigation of the underlying mechanisms contributing to the enhancement of deformation, especially the bubble internal flow patterns and wake behavior. The radial velocity component arises, and hence, the convection mechanism works. The key lies in the synergy between fields of gas velocity and particle concentration, and the synergy angle θ m is proposed to interpret.