CCCCII.—The colouring matters of carajura

Chapman, Ernest; Perkin, Arthur George; Robinson, R. A.

doi:10.1039/jr9270003015

Cited by 68 publications

(51 citation statements)

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“…The analysis of the dye performed decades ago (Chapman, 1927), the isolation of a fl avone (Takemura, 1995) and of three anthocyanidins (Zorn et al, 2001) are the disposable chemical data about this species. Moreover, no pharmacological studies have been reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

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Arrabidaea chica (HBK) Verlot: phytochemical approach, antifungal and trypanocidal activities

Barbosa¹,

Pinto²,

Quignard³

et al. 2008

Rev. bras. farmacogn.

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RESUMO: "Arrabidaea chica (HBK) Verlot: abordagem fi toquímica, atividades tripanocida e antifúngica". Arrabidaea chica (HBK.) Verlot (Bignoniaceae) popularmente, "Pariri", é um arbusto escandente, distribuído do sul do México até a Guiana e Brasil central e é tradicionalmente indicado para tratar sintomas de infl amações e afecções da pele. Seu extrato etanólico foi quimicamente investigado e testado contra leveduras e fungos dermatófi tos. A atividade tripanocida do mesmo extrato foi também avaliada. Este trabalho reporta o isolamento de três fl avonóides, a inibição total do crescimento de Trichophyton mentagrophytes e um signifi cante efeito tripanocida do extrato etanólico e de suas frações. Não foi detectada qualquer toxicidade aguda relevante, mesmo a uma dose de 1000 mg/kg. Unitermos: Arrabidaea chica, Bignoniaceae, fl avonóides, Trichophyton mentagrophytes, atividade antifúngica, Trypanosoma cruzi, efeito tripanocida. ABSTRACT:Arrabidaea chica (HBK.) Verlot (Bignoniaceae) vernacular name "Pariri", is a climbing shrub, widespread from South Mexico to Guyana and central Brazil and is traditionally indicated to treat symptoms of infl ammations and skin affections. Its ethanol extract was chemically investigated and tested against yeasts and dermatophytic fungi. The trypanocidal activity of the same extract was also evaluated. This work reports the isolation of three fl avonoids, the total growth inhibition of Trichophyton mentagrophytes and a signifi cant trypanocidal effect of the ethanol extract and its fractions. No relevant acute toxicity was detected even at a dose of 1000 mg/kg.

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Section: Introductionmentioning

confidence: 99%

“…Since the beginning of this century A. chica has been matter of chemical investigation that aimed to determine the composition of the dye, which was commercialised at that time (Chapman et al, 1927).…”

Section: Introductionmentioning

confidence: 99%

Arrabidaea chica (HBK) Verlot: phytochemical approach, antifungal and trypanocidal activities

Barbosa¹,

Pinto²,

Quignard³

et al. 2008

Rev. bras. farmacogn.

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“…1 Pharmacological activities of A. chica have been the subject of several puplications. [4][5][6][7][8][9][10][11][12] Recently, the Ministry of Health in Brazil expanded the number of medicinal plants of interest for use by the Unified Health System (Sistema Único de Saúde-SUS) in 2008. Among the approval of the seventy medicinal plants is A. chica, which requires its standardization.…”

Section: Introductionmentioning

confidence: 99%

Electrospray ionization mass spectrometry fingerprinting of extracts of the leaves of Arrabidaea chica

Schiozer

Cabral

Chaves

et al. 2012

J. Braz. Chem. Soc.

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Arrabidaea chica (crajiru) é uma importante planta da Amazônia. Seus extratos são usados como pigmento, agentes antimicrobianos e adstringentes. Três variedades diferentes desta espécie são cultivadas na região Amazônica. Neste trabalho, infusões diretas de extratos de A. chica destas três variedade foram analisadas por impressão digital via espectrometria de massas com ionização por eletrospray (ESI(+)-MS). Dados derivados destes espectros foram classificados utilizando um método de análise multivariada (PLS-DA, análise discriminante com calibração multivariada por mínimos quadrados parciais). O método direto aqui apresentado baseia-se na extração de folhas secas e em pó com uma solução de metanol/água acidificada sem manipulação adicional da amostra. A solução sobrenadante foi analisada através de infusão direta por ESI(+)-MS, o que resultou em perfis de composição para cada variedade. 3-Desoxiantocianidinas são importantes substâncias presentes na A. chica, seus íons foram usados como marcadores no tratamento de dados utilizando PLS-DA, o que possibilitou a separação das três variedades. Impressão digital por ESI(+)-MS funciona como um método simples e rápido para diferenciação de variedades de A. chica.Arrabidaea chica (crajiru) is an important Amazonian plant. Its extracts are used as red pigments, antimicrobial agents and astringents. Three different varieties of this species are cultivated in the Amazon region. In this work, direct infusions of A. chica extracts from these three varieties were analyzed via electrospray ionization mass spectrometry (ESI(+)-MS) fingerprinting. Derived data from the spectra were classified by using a multivariate method (PLS-DA, partial least squares-discriminant analysis). The direct method that is herein presented relies on extraction of dry, powdered leaves with acidified methanol/water solution with no further sample preparation. The resulting supernatants were analyzed by direct infusion ESI(+)-MS, which provides characteristic fingerprints of the sample composition. 3-Deoxyanthocyanidins are important substances in A. chica, their ions were used as markers in the PLS-DA data treatment. PLS-DA was able to differentiate the three varieties. ESI(+)-MS fingerprinting works as a simple and fast method to differentiate varieties of A. chica.

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“…Verl., Bignoniaceae, is a shrub plant widespread from South Mexico to central Brazil, particularly in the Amazon basin (Correa, 1931;Takemura et al, 1995). The leaves of the plant have been traditionally used by Brazilians Indians as dye in ritual body painting, to protect the skin against the sunlight and to repel insects (Chapman et al, 1927). Very little is known about the chemical constitution of the leaves (Barbosa et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

“…Very little is known about the chemical constitution of the leaves (Barbosa et al, 2008). Earlier studies of A. chica aimed to determine the composition of the dye (Chapman et al, 1927). Later, a fl avone (Takemura, 1995) and three anthocyanidins (Zorn et al, 2001) were isolated.…”

Section: Introductionmentioning

confidence: 99%

Effect of Arrabidaea chica extracts on the Ehrlich solid tumor development

Ribeiro¹,

Telles²,

Ferraz³

et al. 2012

Rev. bras. farmacogn.

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Abstract:The aim of this study was to investigate the effect of Arrabidaea chica (Humb. & Bonpl.) B. Verl., Bignoniaceae, extracts on Ehrlich solid tumor development in Swiss mice. Leaves of A. chica were extracted with two distinct solvents, ethanol and water. The phytochemical analysis of the extracts indicated different classes of secondary metabolites like as anthocyanidins, fl avonoids, tannins and saponins. Ethanol (EE) and aqueous (AE) extracts at 30 mg/kg reduced the development of Ehrlich solid tumor after ten days of oral treatment. The EE group presented increase in neutrophil count, α1 and β globulin values, and decrease of α2 globulin values. Furthermore, EE reduced the percentage of CD4 + T cells in blood but did not alter the percentage of infl ammatory mononuclear cells associated with tumor suggesting a direct action of EE on tumor cells. Reduced tumor development observed in AE group was accompanied by a lower percentage of CD4 + T lymphocytes in blood. At the tumor microenvironment, this treatment decreased the percentage of CD3 + T cells, especially due to a reduction of CD8 + T subpopulation and NK cells. The antitumor activity presented by the AE is possibly related to an anti-infl ammatory activity. None of the extracts produced toxic effects in animals. In conclusion, the ethanol and aqueous extracts of A. chica have immunomodulatory and antitumor activities attributed to the presence of fl avonoids, such as kaempferol. These effects appear to be related to different mechanisms of action for each extract. This study demonstrates the potential of A. chica as an antitumor agent confi rming its use in traditional popular medicine.

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CCCCII.—The colouring matters of carajura

Cited by 68 publications

References 0 publications

Arrabidaea chica (HBK) Verlot: phytochemical approach, antifungal and trypanocidal activities

Arrabidaea chica (HBK) Verlot: phytochemical approach, antifungal and trypanocidal activities

Electrospray ionization mass spectrometry fingerprinting of extracts of the leaves of Arrabidaea chica

Effect of Arrabidaea chica extracts on the Ehrlich solid tumor development

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