CCl<sub>4</sub>Toxicity

Bd, Dinman; Ea, Hamdi; Cf, Fox; Wj, Frajola

doi:10.1080/00039896.1963.10663595

Cited by 34 publications

(3 citation statements)

References 28 publications

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“…Alanine amino transferase was considered as a marker of hepato cellular damage and in general ALT was considered a more sensitive indicator of liver cell injury than AST (Oser, 1976). Though AST and ALT were not known to have any function in the plasma, but their increase level in the blood indicate cellular damage and increased membrane permeability (Ramazzotto and Carlin, 1978) and their altered metabolism (Dinman et al, 1963).…”

Section: Blood Chemistrymentioning

confidence: 99%

Haematobiochemical Profile in Chronic Acetamiprid Exposure in Sprague Dawley Rats

Mondal¹,

Mukhopadhayay²,

Kumar³

et al. 2015

Adv. Anim. Vet. Sci.

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| A chronic study was conducted on Sprague Dawley (SD) rats for 13 weeks using 48 rats in four groups each having 12 animals. Group I was control. Group II, III and IV were treatment groups receiving acetamiprid in distilled water in the amount of 5mg/kg, 20mg/kg and 40mg/kg, respectively. Body weight gain and feed consumption was decreased. There was lymphocytopenea in acetamiprid treated animal. Liver and kidney marker enzymes and analyte were altered compared to control after 13 weeks of acetamiprid exposure. This study concluded that acetamiprid, used even in this dose range could cause a significant effect on hematobiochemical profile.

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Section: Blood Chemistrymentioning

confidence: 99%

Haematobiochemical Profile in Chronic Acetamiprid Exposure in Sprague Dawley Rats

Mondal¹,

Mukhopadhayay²,

Kumar³

et al. 2015

Adv. Anim. Vet. Sci.

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“…Moreover, some glucocorti coids have a suppressive action on leakage of some enzymes (18). Dinman et al (19) reported that significant increase in serum enzyme activities of most non-mitochondrial, intracellular enzymes occurred immediately after exposure to CCI4 in the absence of necrosis. At the same time, changes at cellular and subcellular levels suggesting altered permeability states were demonstrated by electron microscopic examination.…”

Section: Discussionmentioning

confidence: 99%

Effect of Carbon Tetrachloride Upon Arylesterases in Mice

Takahashi

Nakazawa

Watanabe

1970

Japanese Journal of Pharmacology

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Early works by Augustinsson (1-4) demonstrated that three types of esterases exist in vertebrate plasma in regard to substrate specificity and susceptibility to selective inhi bitors, and he classified them into arylesterases [EC 3. 1. (5) suggested that decrease in the activity of phenyl acetate esterase (corre sponding to arylesterases, according to the Augustinsson's classification) was correlated with the degree of liver damage and that, clinically, the activity of the enzyme in serum decreased greatly in the case of liver cirrhosis. In the present paper, changes in the total activity and the electrophoretic pattern of arylesterases were studied in CC14-induced mouse liver injury using fl-naphthyl acetate as substrate. METHODSExperiment I: Effect of CCl4 administration upon electrophoretic pattern of arylesterases in liver 12,000 X g supernatant and serum Male inbred mice of the NC strain weighing 20 to 24 g were divided into 7 groups of 5 animals each, and treated with 1 ml/kg of CC14 in trap eritoneally except the control group. They were sacrificed at 1/4, 3, 6, 24, 48 and 72 hours after CCI4 injection by ex sanguination from the femoral artery. The liver was immediately removed, rinsed with ice-cold physiological saline and homogenized with an equal amount of 0.05 M phosphate buffer, pH 7.4, by a glass homogenizer with a teflon pestle under refrigeration . The subsequent procedures were performed at fC. The homogenate was centrifuged for 45 minutes at 12,000 X g and the supernatant was separated. The blood collected was also centrifuged for 15 minutes at 3,000 r.p.m. to obtain serum.Thin-layer agar gel electrophoresis described by Ogita (6-8) was performed for 2 hours with the constant current adjusted to 1 mA/cm to separate arylesterases in the super natant of liver homogenate and serum. After electrophoresis, the glass plate covered with agar gel film was immersed into phosphate buffer, pH 6.8, containing Q-naphthyl acetate as substrate and naphthanyl diazo blue B and kept at 37°C for 20 minutes. The

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“…It was deliberated as an indicator of hepatocellular destruction and generally ALT was considered a more critical marker of hepatocyte injury than AST (Oser, 1976). The increased level of ALT and AST in blood denotes cell injury and increase in the membrane permeability (Ramazzotto and Carlin, 1978) and their changed metabolism (Dinman et al, 1963).…”

Section: Ne Usmentioning

confidence: 99%

Modulatory Effect of Ginger Aqueous Extract on Imidacloprid Induced Hepatotoxicity in Rats

Farag¹,

Fotoh²,

EL-Sayed³

et al. 2019

Adv. Anim. Vet. Sci.

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The current study was conducted for evaluation of the hepatotoxic effect of Imidacloprid (IMI) in rats and to assess the modulatory role of Zingiber officinale Roscoe, ginger aqueous extract (GAE), against such effect. Sixty mature male rats (Rattus norvegicus) were utilized and divided into six groups (10 each); group 1 was negative control received 0.1 ml of distilled water, group 2 was positive control which received 1ml of GAE, group 3 administered with 0.1 ml of IMI, group 4:administered 1ml of GAE for 2 weeks followed by administration of 0.1ml of IMI (served as protected group), group 5 administered with 0.1 ml of IMI then 1ml of GAE for 2 weeks (served as treated group) and the last group simultaneously administered with 0.1ml of IMI and 1ml of GAE (served as combination group). Oral dosing of IMI and GAE was triple weekly (day after day) and the experimental period was three months for all groups. IMI exposure caused significant increase in alanine aminotransferase (ALT), aspartate amino transferase (AST) levels, significant decrease in total proteins, albumin and globulins in serum, IMI upregulates interleukin 6 (IL 6), tumor necrosis factorα (TNF-α) and toll like receptor 2 (TLR2) genes in the liver of rats associated with intense immuno positive reactivity of TLR2 and TNF α in the liver of IMI-treated group. Histopathological examination revealed significant alterations in the liver tissue of IMI-treated group, such as disorganization of hepatic cords replaced by mononuclear cells which surrounded by lymphocytes and mild congestion of blood vessels was also seen. In conclusion, the IMI hepatotoxic effect could be modulated by the use of GAE.

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CCl₄Toxicity

Cited by 34 publications

References 28 publications

Haematobiochemical Profile in Chronic Acetamiprid Exposure in Sprague Dawley Rats

Haematobiochemical Profile in Chronic Acetamiprid Exposure in Sprague Dawley Rats

Effect of Carbon Tetrachloride Upon Arylesterases in Mice

Modulatory Effect of Ginger Aqueous Extract on Imidacloprid Induced Hepatotoxicity in Rats

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CCl4Toxicity

Cited by 34 publications

References 28 publications

Haematobiochemical Profile in Chronic Acetamiprid Exposure in Sprague Dawley Rats

Haematobiochemical Profile in Chronic Acetamiprid Exposure in Sprague Dawley Rats

Effect of Carbon Tetrachloride Upon Arylesterases in Mice

Modulatory Effect of Ginger Aqueous Extract on Imidacloprid Induced Hepatotoxicity in Rats

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CCl₄Toxicity