2019
DOI: 10.1111/ajt.15518
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CCL2/MCP-1 and CXCL12/SDF-1 blockade by L-aptamers improve pancreatic islet engraftment and survival in mouse

Abstract: The blockade of pro‐inflammatory mediators is a successful approach to improve the engraftment after islet transplantation. L‐aptamers are chemically synthesized, nonimmunogenic bio‐stable oligonucleotides that bind and inhibit target molecules conceptually similar to antibodies. We aimed to evaluate if blockade‐aptamer‐based inhibitors of C‐C Motif Chemokine Ligand 2/monocyte chemoattractant protein‐1 (CCL2/MCP‐1) and C‐X‐C Motif Chemokine Ligand 12/stromal cell‐derived factor‐1 (CXCL12/SDF‐1) are able to fav… Show more

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Cited by 16 publications
(8 citation statements)
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“…However, it is well known that TNF-α induced in the peritransplant period damages transplanted islets [7]. Furthermore, previous studies have shown that MCP-1 plays a pivotal role as an inflammatory cytokine in the early graft loss of islets [109,110]. On the other hand, it is difficult to evaluate the effect of IL-6 on transplanted islets.…”
Section: Adipocytesmentioning
confidence: 99%
“…However, it is well known that TNF-α induced in the peritransplant period damages transplanted islets [7]. Furthermore, previous studies have shown that MCP-1 plays a pivotal role as an inflammatory cytokine in the early graft loss of islets [109,110]. On the other hand, it is difficult to evaluate the effect of IL-6 on transplanted islets.…”
Section: Adipocytesmentioning
confidence: 99%
“…For example, our previous study found that the DPP‐IV inhibitor Saxagliptin improved the function of islet β cells through regulating SDF‐1 expression 13 . Another study also revealed the important role of SDF‐1 in β cells survival after islet transplantation 14 . Furthermore, during the terminal differentiation stage of mature β cells, SDF‐1 has been proven to prevent apoptosis and necrosis through activating PI3K/AKT and WNT/β‐catenin pathways 15–17 …”
Section: Introductionmentioning
confidence: 99%
“… 13 Another study also revealed the important role of SDF‐1 in β cells survival after islet transplantation. 14 Furthermore, during the terminal differentiation stage of mature β cells, SDF‐1 has been proven to prevent apoptosis and necrosis through activating PI3K/AKT and WNT/β‐catenin pathways. 15 , 16 , 17 …”
Section: Introductionmentioning
confidence: 99%
“…in 1996 as a compelling leukocyte attractant in the supernatants of murine bone marrow cell lines and demonstrated to appeal to both human lymphocytes and monocytes ( 34 ). CXCL12/SDF-1 has been reported both as a stimulator and an antagonist of several perspectives of inflammatory response in type 2 diabetes and its complications and CXCL12/SDF-1might be a promising treatment target to improve islet engraftment ( 35 ). To the best of our knowledge, this study is the first to report the potential pathogenic role of CXCL12/SDF-1 in PCOS and incremental serum levels of CXCL12/SDF-1 in overweight patients with PCOS.…”
Section: Discussionmentioning
confidence: 99%