CCL27 Signaling in the Tumor Microenvironment

Martínez‐Rodríguez, Miguel; Monteagudo, Carlos

doi:10.1007/978-3-030-62658-7_9

Cited by 9 publications

(8 citation statements)

References 126 publications

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“…We took advantage of known CCR10 biology, where CCR10 serves as the sole receptor for the chemokine CCL27 (ref. 20 ). Analogous to natural ligand designs against other targets 21 , we fused full-length CCL27 sequence to a 4-1BB-based, 2nd generation CAR and lentivirally transduced primary human CD8+ T cells (Fig.…”

Section: Resultsmentioning

confidence: 99%

The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance

et al. 2022

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The myeloma surface proteome (surfaceome) determines tumor interaction with the microenvironment and serves as an emerging arena for therapeutic development. Here, we use glycoprotein capture proteomics to define the myeloma surfaceome at baseline, in drug resistance, and in response to acute drug treatment. We provide a scoring system for surface antigens and identify CCR10 as a promising target in this disease expressed widely on malignant plasma cells. We engineer proof-of-principle chimeric antigen receptor (CAR) T-cells targeting CCR10 using its natural ligand CCL27. In myeloma models we identify proteins that could serve as markers of resistance to bortezomib and lenalidomide, including CD53, CD10, EVI2B, and CD33. We find that acute lenalidomide treatment increases activity of MUC1-targeting CAR-T cells through antigen upregulation. Finally, we develop a miniaturized surface proteomic protocol for profiling primary plasma cell samples with low inputs. These approaches and datasets may contribute to the biological, therapeutic, and diagnostic understanding of myeloma.

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Section: Resultsmentioning

confidence: 99%

The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance

et al. 2022

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“…C-c motif chemokine ligand 27 (CCL27), a chemokine primarily expressed by keratinocytes, and its enhanced expression activate the extracellular signal-regulated kinase 1/2 (ERK1/2) pathway and in turn overexpress MMP-7 leads to cell invasion and migration of breast cancers ( Korbecki et al, 2020 ). Chemokines are a class of small proteins that play an important role in leukocyte migration and invasion ( Martínez-Rodríguez and Monteagudo, 2021 ). They have the ability to participate in tumor cell cellular proliferation and migration.…”

Section: Introductionmentioning

confidence: 99%

Insights Into the Role of Matrix Metalloproteinases in Cancer and its Various Therapeutic Aspects: A Review

Mustafa

Koran

AlOmair

2022

Front. Mol. Biosci.

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Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that regulate the turnover of extracellular matrix (ECM) components. Gross and La Piere discovered MMPs in 1962 during an experiment on tissue samples from a tadpole’s tail. Several subtypes of MMPs have been identified, depending on their substrate specificity and localization. MMPs are involved as essential molecules in multiple and diverse physiological processes, such as reproduction, embryonic development, bone remodeling, tissue repair, and regulation of inflammatory processes. Its activity is controlled at various levels such as at transcription level, pro-peptide activation level and by the activity of a family of tissue inhibitors of metalloproteinase, endogenous inhibitors of MMPs. Cancer metastasis, which is the spread of a tumor to a distant site, is a complex process that is responsible for the majority of cancer-related death It is considered to be an indicator of cancer metastasis. During metastasis, the tumor cells have to invade the blood vessel and degrade the ECM to make a path to new loci in distant places. The degradation of blood vessels and ECM is mediated through the activity of MMPs. Hence, the MMP activity is critical to determining the metastatic potential of a cancer cell. Evasion of apoptosis is one of the hallmarks of cancer that are found to be correlated with the expression of MMPs. As a result, given the importance of MMPs in cancer, we describe the role of these multifunctional enzymes MMPs in various aspects of cancer formation and their rising possibilities as a novel therapeutic target in this review. There is also a brief discussion of various types of therapeutic components and drugs that function against MMPs.

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“…In addition, CCL2 plays a role in the recruitment of tumor-associated macrophages, which promote tumor phenotype generation as well as tumor cell invasion and angiogenesis ( O'Connor and Heikenwalder 2021 ). The same is true for CCL24/27 ( Lim 2021 ; Martínez-Rodríguez and Monteagudo 2021 ). CXCL13 and the receptor CXCR5 represent an emerging example of a chemokine signaling axis that demonstrates the ability to regulate tumor growth and progression.…”

Section: Anti-tumor Effect Of Chemokinesmentioning

confidence: 52%

Advances in Research on the Effects and Mechanisms of Chemokines and Their Receptors in Cancer

Chen

et al. 2022

Front. Pharmacol.

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Cancer is a common and intractable disease that seriously affects quality of life of patients and imposes heavy economic burden on families and the entire society. Current medications and intervention strategies for cancer have respective shortcomings. In recent years, it has been increasingly spotlighted that chemokines and their receptors play vital roles in the pathophysiology of cancer. Chemokines are a class of structurally similar short-chain secreted proteins that initiate intracellular signaling pathways through the activation of corresponding G protein-coupled receptors and participate in physiological and pathological processes such as cell migration and proliferation. Studies have shown that chemokines and their receptors have close relationships with cancer epigenetic regulation, growth, progression, invasion, metastasis, and angiogenesis. Chemokines and their receptors may also serve as potential targets for cancer treatment. We herein summarize recent research progresses on anti-tumor effects and mechanisms of chemokines and their receptors, suggesting avenues for future studies. Perspectives for upcoming explorations, such as development of multi-targeted chemokine-based anti-tumor drugs, are also discussed in the present review.

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CCL27 Signaling in the Tumor Microenvironment

Cited by 9 publications

References 126 publications

The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance

The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance

Insights Into the Role of Matrix Metalloproteinases in Cancer and its Various Therapeutic Aspects: A Review

Advances in Research on the Effects and Mechanisms of Chemokines and Their Receptors in Cancer

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