CCND1 G870A polymorphism and cervical cancer risk: a case–control study and meta-analysis

Ni, Jiazuan; Wang, Meilin; Wang, Miaomiao; Fu, Shilong; Zhou, Detang; Zhang, Zhengdong; Han, Song

doi:10.1007/s00432-010-0904-x

Cited by 15 publications

(11 citation statements)

References 22 publications

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“…In 2011, Ni et al reported the first meta-analysis on the association between CCND1 G870A polymorphism and cervical cancer risk [17]. Only five studies were included in their review.…”

Section: Discussionmentioning

confidence: 99%

Association between cyclin D1 G870A polymorphism and cervical cancer risk: a cumulative meta-analysis involving 2,864 patients and 3,898 controls

Zheng

Guo

et al. 2014

Diagn Pathol

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BackgroundAssociation between Cyclin D1 (CCND1) polymorphism and cervical cancer risk are conflicting with published articles. We performed a meta-analysis to investigate the association between CCND1 G870A polymorphism and cervical cancer risk.MethodsPubMed, Embase and CNKI data were researched to conduct a meta-analysis on the associations between CCND1 G870A polymorphism and cervical cancer risk. Ten published case–control studies including 2,864 patients with cervical cancer and 3,898 controls were collected in this meta-analysis. Odds ratio (OR) with 95% confidence interval (CI) were applied to assess the relationship; meta-regression, sensitivity analysis and cumulative analysis were also conducted to guarantee the strength of results.ResultsOverall, no significant association between CCND1 G870A polymorphism and cervical cancer risk were found in allele contrast (A vs. G: OR = 1.02, 95% CI = 0.88-1.19, P = 0.76 I2 = 74.5%), codominant model (GA vs. GG: OR = 0.98, 95% CI = 0.77-1.26, P = 0.90 I2 = 69.1%; AA vs GG: OR = 1.03, 95% CI = 0.75-1.41, P = 0.85 I2 = 75.9%), dominant model (GA + AA vs. GG: OR = 1.00, 95% CI = 0.78-1.28, P = 0.99 I2 = 72.3%) and recessive model (AA vs GG + GA: OR = 1.06, 95% CI = 0.85-1.23, P = 0.62, I2 = 70.1%). Similarly, in the stratified analysis by ethnicity, study design and genotyping type, no significant association detected in all genetic models either.ConclusionsOur meta-analysis indicated that CCND1 G870A might be not the crucial risk factor for the development of cervical cancer.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_168

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“…In 2011, Ni et al reported the first meta-analysis on the association between CCND1 G870A polymorphism and cervical cancer risk [17]. Only five studies were included in their review.…”

Section: Discussionmentioning

confidence: 99%

Association between cyclin D1 G870A polymorphism and cervical cancer risk: a cumulative meta-analysis involving 2,864 patients and 3,898 controls

Zheng

Guo

et al. 2014

Diagn Pathol

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“…Several recent studies have reported an association between the Cyclin D1 polymorphism (A870G) and an increased risk of developing various solid tumors [20][21][22][23][25][26][27][28][29][31][32][33][34][35][36][37][38][39][40][41][42][43]. But this association might be ethnic different.…”

Section: Discussionmentioning

confidence: 98%

Cyclin D1 gene polymorphism, A870G, is associated with an increased risk of salivary gland tumors in the Chinese population

Liu

Wang

et al. 2011

Cancer Epidemiology

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“…Similarly, the A allele appears to increase cancer risk in Chinese populations for breast (38) and bladder cancer (39), indicating that A allele carriers may produce an elevated cancer risk. However, a meta-analysis conducted on cervical cancer (40) failed to show this marked association. Similarly, no evidence supports the association of CCND1 genetic variation with head and neck cancer (41) in a recently published meta-analysis, of which the data were combined as head and neck cancer rather than oral carcinoma, and two important studies (29,32) on oral cancer that met the inclusion criteria were ignored.…”

Section: Discussionmentioning

confidence: 99%

Lack of association of the cyclin D1 G870A variation with oral carcinoma risk: Evidence from 2,404 subjects

Zhuo

Ling

Zhao

et al. 2012

Experimental and Therapeutic Medicine

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Evidence implicates cyclin D1 (CCND1) G870A polymorphisms as risk factors for various cancers. An increasing number of investigations have been conducted on the association of CCND1 G870A polymorphisms with susceptibility to oral carcinoma, and have yielded inconclusive results. The aim of the present study was to derive a more precise estimation of the correlation. Meta-analyses examining the association between CCND1 G870A polymorphisms and oral carcinoma were performed. Separate analyses on ethnicity, smoking status and control sources were also implemented. Eligible studies were identified prior to February 2012. From the overall data from 1,128 cases and 1,276 controls, no associations of CCND1 G870A polymorphisms with oral carcinoma were observed [AA vs. GG: odds ratio (OR)=1.06; 95% confidence interval (CI), 0.62–1.82; dominant model: OR=1.04; 95% CI, 0.76–1.43; recessive model: OR=1.06; 95% CI, 0.70–1.59]. In the subgroup analysis by ethnicity, smoking status and control sources, no significant associations of CCND1 G870A polymorphisms and oral cancer were observed for the three genetic models. Collectively, the data failed to suggest CCND1 G870A polymorphism as a low-penetrant risk factor for developing oral carcinoma. Additional studies with large sample sizes concerning different ethnicities in different areas are required.

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CCND1 G870A polymorphism and cervical cancer risk: a case–control study and meta-analysis

Abstract: The G870A polymorphism in CCND1 may not contribute to the etiology of cervical cancer in Chinese populations.

Cited by 15 publications

References 22 publications

Association between cyclin D1 G870A polymorphism and cervical cancer risk: a cumulative meta-analysis involving 2,864 patients and 3,898 controls

Association between cyclin D1 G870A polymorphism and cervical cancer risk: a cumulative meta-analysis involving 2,864 patients and 3,898 controls

Cyclin D1 gene polymorphism, A870G, is associated with an increased risk of salivary gland tumors in the Chinese population

Lack of association of the cyclin D1 G870A variation with oral carcinoma risk: Evidence from 2,404 subjects

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