CCR5 promoter human haplogroups associated with HIV-1 disease progression in Thai injection drug users

Nguyen, Lily H. P.; Li, Ming; Chaowanachan, Thanyanan; Hu, Dale J.; Vanichseni, Suphak; Mock, Philip A.; Griensven, Frits van; Martin, Michael; Sangkum, Udomsak; Choopanya, Kachit; Tappero, Jordan W.; Lal, Renu B.; Yang, Chunfu

doi:10.1097/00002030-200406180-00012

Cited by 27 publications

(34 citation statements)

References 39 publications

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“…Lipid rafts/caveolae have been suggested to play a role in chemotaxis. This is based on the observation that oxidation of cholesterol or enriching the plasma membrane with 22-hydroxycholesterol results in inhibition of CCR5-mediated chemotaxis [106][107][108]. Moreover, inhibition of lipid raft formation prevents CXCL12-dependent migration [109].…”

Section: Role Of Lipid Rafts/caveloae In Chemokine Receptors Functionsmentioning

confidence: 99%

Chemokine receptor internalization and intracellular trafficking

Neel

Schutyser

Sai

et al. 2005

Cytokine & Growth Factor Reviews

203

218

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The internalization and intracellular trafficking of chemokine receptors have important implications for the cellular responses elicited by chemokine receptors. The major pathway by which chemokine receptors internalize is the clathrin-mediated pathway, but some receptors may utilize lipid rafts/ caveolae-dependent internalization routes. This review discusses the current knowledge and controversies regarding these two different routes of endocytosis. The functional consequences of internalization and the regulation of chemokine receptor recycling will also be addressed. Modifications of chemokine receptors, such as palmitoylation, ubiquitination, glycosylation, and sulfation, may also impact trafficking, chemotaxis and signaling. Finally, this review will cover the internalization and trafficking of viral and decoy chemokine receptors.

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Section: Role Of Lipid Rafts/caveloae In Chemokine Receptors Functionsmentioning

confidence: 99%

Chemokine receptor internalization and intracellular trafficking

Neel

Schutyser

Sai

et al. 2005

Cytokine & Growth Factor Reviews

203

218

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“…Based on a unique constellation of additional multisite polymorphisms in CCR5 regulatory 5' region, a number of CCR5 haplotypes have been identified (Gonzalez et al,1999;Martin et al, 1998). They have been designed based on the nucleotide position in the 5' untranslated region (UTR) and are referred to as human haplogroups A to G. Of these, HHE has been associated with accelerated disease progression in Caucasians (Gonzalez et al, 1999) and Thais (Nguyen et al, 2004) but not in African Americans. The HHC and HHD haplotypes showed positive association with fast progression to AIDS in African Americans (Kostrikis et al, 1999;Nguyen et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

“…They have been designed based on the nucleotide position in the 5' untranslated region (UTR) and are referred to as human haplogroups A to G. Of these, HHE has been associated with accelerated disease progression in Caucasians (Gonzalez et al, 1999) and Thais (Nguyen et al, 2004) but not in African Americans. The HHC and HHD haplotypes showed positive association with fast progression to AIDS in African Americans (Kostrikis et al, 1999;Nguyen et al, 2004). In the Indian population, HHE has been implicated with susceptibility to infection and development of AIDS .…”

Section: Introductionmentioning

confidence: 99%

The Role of Genetic Polymorphisms in the Chemokine and their Receptors and Cytokines in the Human Immunodeficiency Virus Type 1 (HIV-1) Infection

Reiche¹,

Amarante²,

Watanabe³

2011

HIV and AIDS - Updates on Biology, Immunology, Epidemiology and Treatment Strategies

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“…Some of these have been associated with either resistance (HHG2, HHA, HHF2) (2,4,5) or increased susceptibility to HIV-1 infection and accelerated AIDS progression (HHE) (6)(7)(8). Furthermore, polymorphisms located in promoter or intronic regions of the natural ligands of CCR5, CCL3 (also known as MIP-1α, encoded by CCL3) and CCL5 (also known as RANTES, encoded by CCL5) could modify the secretion levels of these peptides further influencing the resistance or susceptibility (R/S) to HIV-1 infection by competition with the CCR5 coreceptor (3).…”

mentioning

confidence: 99%

Haplotypes in CCR5-CCR2, CCL3 and CCL5 are associated with natural resistance to HIV-1 infection in a Colombian cohort

Vega¹,

Villegas-Ospina²,

Aguilar-Jiménez³

et al. 2017

biomedica

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Introduction: Variants in genes encoding for HIV-1 co-receptors and their natural ligands have been individually associated to natural resistance to HIV-1 infection. However, the simultaneous presence of these variants has been poorly studied. Objective: To evaluate the association of single and multilocus haplotypes in genes coding for the viral co-receptors CCR5 and CCR2, and their ligands CCL3 and CCL5, with resistance or susceptibility to HIV-1 infection. Materials and methods: Nine variants in CCR5-CCR2, two SNPs in CCL3 and two in CCL5 were genotyped by PCR-RFLP in 35 seropositive (cases) and 49 HIV-1-exposed seronegative Colombian individuals (controls). Haplotypes were inferred using the Arlequin software, and their frequency in individual or combined loci was compared between cases and controls by the chi-square test. A p' value <0.05 after Bonferroni correction was considered significant. Results: Homozygosis of the human haplogroup (HH) E was absent in controls and frequent in cases,showing a tendency to susceptibility. The haplotypes C-C and T-T in CCL3 were associated with susceptibility (p'=0.016) and resistance (p'<0.0001) to HIV-1 infection, respectively. Finally, in multilocus analysis, the haplotype combinations formed by HHC in CCR5-CCR2, T-T in CCL3 and G-C in CCL5 were associated with resistance (p'=0.006). Conclusion: Our results suggest that specific combinations of variants in genes from the same signaling pathway can define an HIV-1 resistant phenotype. Despite our small sample size, our statistically significant associations suggest strong effects; however, these results should be further validated in larger cohorts.

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CCR5 promoter human haplogroups associated with HIV-1 disease progression in Thai injection drug users

Abstract: This is the first evidence that the CCR5 haplogroup E speeds the decline of the CD4 cell count and may lead to accelerated disease progression among HIV-infected Thais. These new observations highlight the need for additional studies involving populations in Asia.

Cited by 27 publications

References 39 publications

Chemokine receptor internalization and intracellular trafficking

Chemokine receptor internalization and intracellular trafficking

The Role of Genetic Polymorphisms in the Chemokine and their Receptors and Cytokines in the Human Immunodeficiency Virus Type 1 (HIV-1) Infection

Haplotypes in CCR5-CCR2, CCL3 and CCL5 are associated with natural resistance to HIV-1 infection in a Colombian cohort

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