CD-34 stromal expression pattern in normal and altered human corneas

Histopathological findings after intracorneal ring segment implantation in keratoconic human corneas

“…16 It has been known since 2002 that CD34 is expressed on human keratocytes but not by the epithelium or endothelium. 17 In 2003, Joseph et al 16 suggested CD34 plays a role in cytoadhesion and signaling related to differentiation and proliferation.…”

Expression and Distribution of Junctional Adhesion Molecule-1 in the Human Cornea

“…[25][26][27][28][29] Corneal myofibroblasts differ from keratocytes with respect to morphology, proliferative activity, phagocytic activity, extracellular matrix production, and expression of various proteins such as CD34, keratocan, and α-SMA. [18][19][20][21][30][31][32][33] The corneal myofi broblast is defi ned by both its morphology and the presence of α-SMA. In this study, we found that when keratocytes were cultured in medium containing FCS for two or three passages, expression of CD34 and keratocan decreased, whereas expression of α-SMA and JAM-1 increased.…”

Silk fibroin in ocular tissue reconstruction

“…A range of markers are also available to assess stromal cell phenotype. In situ, corneal keratocytes express CD34 [69], but during cultivation in the presence of serum this marker is quickly lost and replaced by markers for wound healing fibroblasts (CD90) and myofibroblasts (a-smooth muscle actin) [70]. The differentiated corneal endothelium is generally characterised by a tightly cobblestoned morphology, but perhaps a more important study will be to assess the degree of cell density and pump functions which are required to maintain a clear corneal stroma.…”