CD147 expression was positively linked to aggressiveness and worse prognosis of gastric cancer: a meta and bioinformatics analysis

Zheng, Haixue; Gong, Baocheng

doi:10.18632/oncotarget.20089

Cited by 10 publications

(9 citation statements)

References 46 publications

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“…Moreover, some scholars detected a high expression of CD 147 in gastric cancer. In a meta and bioinformatics analysis, Zheng and colleagues7 found that the expression of CD147 was positively correlated with tumor size, depth of invasion, lymph node metastasis, TNM staging and unfavorable prognosis in gastric cancer 7. We had the same conclusion in this study.…”

Section: Discussionsupporting

confidence: 76%

“…In addition, CD147 and miR203 were also studied by scholars as their close relationship with gastric cancer. CD147, which was isolated from lung carcinoma cells, can increase cancer invasion by inducing MMP synthesis in neighboring fibroblasts, endothelial and cancer cells 7. Chu investigated the level of CD147 in 223 gastric cancer patients, and confirmed the association of CD147 with gastric cancer invasion and metastasis, suggesting that CD147 may be an indicator of tumor recurrence and prognosis 8.…”

Section: Introductionmentioning

confidence: 86%

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Analysis of the expression of D-dimer, CD147 and miR203 and their correlation in gastric cancer

Wu¹,

Liu²

2019

Pak J Med Sci

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Objectives: To evaluate the relationship of D-dimer, CD147 and miR-203, and detect the influence of these biomarkers on the pathological characteristics in patients with gastric cancer. Methods: The patients with gastric cancer treated using radical gastrectomy between May 2013 and October 2017 were reviewed retrospectively. The expression of D-dimer, miR203 and CD147 was measured for all the patients, and the clinical data including age, gender, tumor size, tumor differentiation, invasion depth, lymphatic metastasis, TMN stage, and pathological type were retrieved and analyzed. The study was carried out in affiliated Yidu Central Hospital of Weifang Medical College, Qingzhou, China. Results: Two hundred sixty patients with gastric cancer were included. The patients with tumor metastasis, larger tumor diameter, lower differentiation, lymphatic metastasis, deeper invasion, and higher TMN stage presented with a significantly higher D-dimer and CD 147 expression, but the level of the two biomarkers didn’t show a significant difference in patients with different pathological type, gender and age. Compared with CD147 and D-dimer, miR203 presented with different characteristics of expression. In addition, the expression of miR203 was negatively correlated with CD147 and D-dimer, and there was a positive correlation between CD147 and D-dimer in patients with gastric cancer. Conclusion: In this study, a close correlation of D-dimer, miR203 and CD147 was found, and these three biomarkers should be screened in gastric cancer patients. How to cite this:Wu X, Liu X. Analysis of the expression of D-dimer, CD147 and miR203 and their correlation in gastric cancer. Pak J Med Sci. 2019;35(2):---------. doi: https://doi.org/10.12669/pjms.35.2.718 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionsupporting

confidence: 76%

Section: Introductionmentioning

confidence: 86%

Analysis of the expression of D-dimer, CD147 and miR203 and their correlation in gastric cancer

Wu¹,

Liu²

2019

Pak J Med Sci

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“…CD147, also termed as EMMPRIN or basigin, is a pleiotropic molecule with various effects (Grass & Toole, 2016 ; Iacono et al., 2007 ). Given the emerging use of bioinformatics in biological research (Karim et al., 2020 ; Mehmood et al., 2014 ), it is worth mentioning that, through pathway analyses, CD147 was found to be a significant cell-surface protein contributing to chemoresistance and cell survival in cancer-stem-cell-like cells (Kang et al., 2013 ), and the invasion of various cancers (Li et al., 2015 ; Liang et al., 2016 ; Zheng & Gong, 2017 ). Additionally, it was found to be highly expressed in activated regulatory T lymphocytes, enabling it to be a potential marker for distinguishing cytokine-producing activated T lymphocytes from resting T lymphocytes (Landskron & Taskén, 2013 ; Solstad et al., 2011 ).…”

Section: Resultsmentioning

confidence: 99%

Molecular basis of the potential interaction of SARS-CoV-2 spike protein to CD147 in COVID-19 associated-lymphopenia

Helal

Shouman

Abdelwaly

et al. 2020

Journal of Biomolecular Structure and Dynamics

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Lymphopenia is considered one of the most characteristic clinical features of the coronavirus disease 2019 (COVID-19). SARS-CoV-2 infects host cells via the interaction of its spike protein with the human angiotensin-converting enzyme 2 (hACE2) receptor. Since T lymphocytes display a very low expression level of hACE2, a novel receptor might be involved in the entry of SARS-CoV-2 into T cells. The transmembrane glycoprotein CD147 is highly expressed by activated T lymphocytes, and was recently proposed as a probable route for SARS-CoV-2 invasion. To understand the molecular basis of the potential interaction of SARS-CoV-2 to CD147, we have investigated the binding of the viral spike protein to this receptor in-silico. The results showed that this binding is dominated by electrostatic interactions involving residues Arg403, Asn481, and the backbone of Gly502. The overall binding arrangement shows the CD147 C-terminal domain interacting with the spike external subdomain in the grove between the short antiparallel b strands, b1' and b2', and the small helix a1'. This proposed interaction was further confirmed using MD simulation and binding free energy calculation. These data contribute to a better understanding of the mechanism of infection of SARS-CoV-2 to T lymphocytes and could provide valuable insights for the rational design of adjuvant treatment for COVID-19.

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“…CD147, a transmembrane glycoprotein, belongs to the immunoglobulin superfamily and is widely expressed on the surface of cancer cells . Reports showed that CD147 was over‐expressed in many types of cancer, such as human malignant melanoma, hepatocellular carcinoma, lung cancer, gastric cancer, breast cancer and so on . CD147 is also reported to involve in tumor progression, angiogenic function and immune response …”

Section: Introductionmentioning

confidence: 99%

“…6 Reports showed that CD147 was over-expressed in many types of cancer, such as human malignant melanoma, hepatocellular carcinoma, lung cancer, gastric cancer, breast cancer and so on. [7][8][9][10][11][12] CD147 is also reported to involve in tumor progression, angiogenic function and immune response. 13,14 Furthermore, many studies demonstrated that CD147 could stimulate the activation of nuclear factor kappa B (NF-kappa B) pathway.…”

mentioning

confidence: 99%

CD147 promotes progression of head and neck squamous cell carcinoma via NF‐kappa B signaling

Zhang

et al. 2018

J Cellular Molecular Medi

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CD147/basigin (BSG) is highly upregulated in many types of cancer, our previous study has found that CD147/BSG is highly expressed in head and neck squamous cell carcinoma (HNSCC) stem cells, but its role in HNSCC and the underlying mechanism is still unknown. In this study, we investigated the role of CD147 in the progression of HNSCC. Real‐time PCR, western blot and immunohistochemistry were used to detect the expression of CD147 in total 189 HNSCC tissues in compared with normal tissues. In addition, we used proliferation, colony formation, cell cycle and apoptosis, migration and invasion as well as wound‐healing assay to determine the biological roles of CD147 in HNSCC. Then, a xenograft model was performed to evaluate tumor‐promoting and metastasis‐promoting role of CD147 in HNSCC. The results showed that upregulated CD147 expression was associated with aggressive clinicopathologic features in HNSCC. In addition, CD147 promoted proliferation, migration and reduced the apoptosis phenotype of HNSCC cells in vitro as well as tumor initiation and progression in vivo. Furthermore, we demonstrated that CD147 promoted HNSCC progression through nuclear factor kappa B signaling. Therefore, we concluded that CD147 promoted tumor progression in HNSCC and might be a potential prognostic and treatment biomarker for HNSCC.

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CD147 expression was positively linked to aggressiveness and worse prognosis of gastric cancer: a meta and bioinformatics analysis

Cited by 10 publications

References 46 publications

Analysis of the expression of D-dimer, CD147 and miR203 and their correlation in gastric cancer

Analysis of the expression of D-dimer, CD147 and miR203 and their correlation in gastric cancer

Molecular basis of the potential interaction of SARS-CoV-2 spike protein to CD147 in COVID-19 associated-lymphopenia

CD147 promotes progression of head and neck squamous cell carcinoma via NF‐kappa B signaling

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