CD147 overexpression may serve as a promising diagnostic and prognostic marker for gastric cancer: evidence from original research and literature

Hu, Chenghao; Xiao, Dong; Wu, Jing; Xiao, Fei; Shang, Jun; Liu, Liang; Yang, Yuan; Luo, Dongmei; Li, Qiuting; Song, Qian; Yang, Jingcheng; Zhang, Chengdong; Shen, Li; Luo, Zhiguo

doi:10.18632/oncotarget.15737

Cited by 6 publications

(4 citation statements)

References 29 publications

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“…It has been reported that CD147 acting as a tumor related protein may contribute to the biological abnormity of cancers, promoting cells metastasis and invasion. Over-expression of CD147 has been found in a variety of tumors and exerts its roles in gastric cancer 16 , hepatocellular carcinoma 17 , lung cancer 18 , prostate cancer 19 et al Tao Xu et al 20 showed that CD147 expressed higher in human CRC and increased abilities of cell invasiveness and epithelial-to-mesenchymal transition through activating MAPK/ERK pathway. Furthermore, our previous study has found that CD147 significantly contributes to tumor growth and metastasis in CRC 21 .…”

Section: Discussionmentioning

confidence: 99%

microRNA-485-5p Functions as a Tumor Suppressor in Colorectal Cancer Cells by Targeting CD147

Hu¹,

Xu²,

He³

et al. 2018

J. Cancer

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Colorectal cancer(CRC) is a prevalent malignancy in the world. There is growing evidence that microRNAs (miRNAs) as crucial modulator are in connection with many tumor-related diseases including CRC. Though miR-485-5p has been reported as an anti-oncogene in certain cancers, it remains unclear in CRC. In this research, we found that miR-485-5p was at lower level expression in CRC tissues and cell lines compared to the paired paracancerous tissues and the normal colon epithelial cell line FHC, correspondingly. Furthermore, Experimental up-regulation miR-485-5p in DLD-1 and SW480 cells with mimic could inhibit the ability of proliferation, migration, invasion of CRC cell lines and facilitate cells apoptosis. Also, we confirmed that CD147 existed typically negative regulation by miR-485-5p through binding a conserved sequence specifically within the CD147 3′-untranslated region (3′UTR) and reintroduction of CD147 could rescue the phenotypic changes caused by miR-485-5p. The findings provide evidence to demonstrate the role of miR-485-5p/CD147 interaction in CRC and indicate that miR-485-5p might be exploited therapeutically in CRC.

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Section: Discussionmentioning

confidence: 99%

microRNA-485-5p Functions as a Tumor Suppressor in Colorectal Cancer Cells by Targeting CD147

Hu¹,

Xu²,

He³

et al. 2018

J. Cancer

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“…Recently, Hu et al [ 68 ] has reported that CD147 overexpression may serve as a promising diagnostic and prognostic marker for gastric cancer using a meta- and immunohistochemical study. The differences between our and Hu's studies are summarized as follows: 1) We have clarified the clinicopathological and prognostic significances of CD147 protein expression as previously reported [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

CD147 expression was positively linked to aggressiveness and worse prognosis of gastric cancer: a meta and bioinformatics analysis

Zheng

Gong

2017

Oncotarget

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CD147 (also named as Basigin or EMMPRIN) might promote cancer invasion and metastasis by inducing MMP and VEGF synthesis in tumor microenvironment. We performed a systematic meta and bioinformatics analysis through multiple online databases up to March 14, 2017. Up-regulated CD147 expression was found in gastric cancer, compared with normal mucosa (p < 0.05). The male patients with gastric cancer showed higher CD147 expression than the female ones (p < 0.0001). CD147 expression was positively correlated with tumor size, depth of invasion, lymph node metastasis, TNM staging and unfavorable prognosis of gastric cancer (p < 0.05). At mRNA level, CD147 expression was higher in intestinal-type and mixed-type gastric carcinomas than normal tissues (p < 0.05). CD147 mRNA expression was negatively associated with histological grading and dedifferentiation of gastric cancer (p < 0.05). A higher CD147 mRNA expression was negatively correlated with overall and progression-free survival rates of all cancer patients, even stratified by clinicopathological features (p < 0.05). These findings indicated that CD147 expression might be employed as a potential marker to indicate gastric carcinogenesis and subsequent progression, even prognosis.

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“…Chu investigated the level of CD147 in 223 gastric cancer patients, and confirmed the association of CD147 with gastric cancer invasion and metastasis, suggesting that CD147 may be an indicator of tumor recurrence and prognosis 8. Hu’s study concluded the same conclusion 9. In terms of miR-203, its influence on gastric cancer was also studied in recent years, many scholars advocated that the expression of miR-203 was significantly lower in gastric cancer samples than non-cancerous samples, also demonstrating a close correlation between miR-203 and gastric cancer 10,11…”

Section: Introductionmentioning

confidence: 80%

Analysis of the expression of D-dimer, CD147 and miR203 and their correlation in gastric cancer

Wu¹,

Liu²

2019

Pak J Med Sci

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Objectives: To evaluate the relationship of D-dimer, CD147 and miR-203, and detect the influence of these biomarkers on the pathological characteristics in patients with gastric cancer. Methods: The patients with gastric cancer treated using radical gastrectomy between May 2013 and October 2017 were reviewed retrospectively. The expression of D-dimer, miR203 and CD147 was measured for all the patients, and the clinical data including age, gender, tumor size, tumor differentiation, invasion depth, lymphatic metastasis, TMN stage, and pathological type were retrieved and analyzed. The study was carried out in affiliated Yidu Central Hospital of Weifang Medical College, Qingzhou, China. Results: Two hundred sixty patients with gastric cancer were included. The patients with tumor metastasis, larger tumor diameter, lower differentiation, lymphatic metastasis, deeper invasion, and higher TMN stage presented with a significantly higher D-dimer and CD 147 expression, but the level of the two biomarkers didn’t show a significant difference in patients with different pathological type, gender and age. Compared with CD147 and D-dimer, miR203 presented with different characteristics of expression. In addition, the expression of miR203 was negatively correlated with CD147 and D-dimer, and there was a positive correlation between CD147 and D-dimer in patients with gastric cancer. Conclusion: In this study, a close correlation of D-dimer, miR203 and CD147 was found, and these three biomarkers should be screened in gastric cancer patients. How to cite this:Wu X, Liu X. Analysis of the expression of D-dimer, CD147 and miR203 and their correlation in gastric cancer. Pak J Med Sci. 2019;35(2):---------. doi: https://doi.org/10.12669/pjms.35.2.718 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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CD147 overexpression may serve as a promising diagnostic and prognostic marker for gastric cancer: evidence from original research and literature

Cited by 6 publications

References 29 publications

microRNA-485-5p Functions as a Tumor Suppressor in Colorectal Cancer Cells by Targeting CD147

microRNA-485-5p Functions as a Tumor Suppressor in Colorectal Cancer Cells by Targeting CD147

CD147 expression was positively linked to aggressiveness and worse prognosis of gastric cancer: a meta and bioinformatics analysis

Analysis of the expression of D-dimer, CD147 and miR203 and their correlation in gastric cancer

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