CD1d-Independent Developmental Acquisition of Prompt IL-4 Gene Inducibility in Thymus CD161(NK1)−CD44lowCD4+CD8− T Cells Is Associated with Complementarity Determining Region 3-Diverse and Biased Vβ2/Vβ7/Vβ8/Vα3.2 T Cell Receptor Usage

Chen, Yi-Ting; Kung, John T.

doi:10.4049/jimmunol.175.10.6537

Cited by 9 publications

(21 citation statements)

References 102 publications

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“…30,31 To test the TCR-Vb repertoire on CD1611FoxP31 cells, flow cytometry staining for TCR-Vb families was performed. The expression of 24 TCR-Vb families was investigated within 5 different T-cell subsets: total CD41, CD161-FoxP31CD41, CD1611FoxP31CD41, CD161-FoxP3-CD41, and CD1611FoxP3-CD41 lymphocytes (Figure 4).…”

Section: Cd1611 Treg Use a Diverse Tcr-vb Repertoirementioning

confidence: 99%

CD161 defines the subset of FoxP3+ T cells capable of producing proinflammatory cytokines

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et al. 2013

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Section: Cd1611 Treg Use a Diverse Tcr-vb Repertoirementioning

confidence: 99%

CD161 defines the subset of FoxP3+ T cells capable of producing proinflammatory cytokines

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Ursu

et al. 2013

Blood

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“…Development of the IL-4 inducibility + subset of naı¨ve CD4 + T cells is dependent on MHC-II and independent of b2m, CD1d, and p59 fyn [7]. IL-4 inducibility + TCR-cd T cells have been found to be mostly of fetal origin [11] whereas NKT cells been shown to develop from adult bone marrow [12].…”

Section: Developmentmentioning

confidence: 98%

“…IL-4 inducibility + TCR-cd T cells have been found to be mostly of fetal origin [11] whereas NKT cells been shown to develop from adult bone marrow [12]. IL-4 inducibility + CD4 + T cells, because of their MHC-II-restricted nature [7], will most likely develop from adult bone marrow precursors also. Recovery from an acute depletion induced by drugs or radiation of adults is expected for NKT cells and CD4 + T cells but unlikely for the IL-4 inducibility + TCR-cd T cells.…”

Section: Developmentmentioning

confidence: 98%

“…On the other hand, IL-4 inducibility by naive CD4 + T cells and TCR-cd T cells are limited to a small subset [6][7][8]. Whether IL-4 inducibility + TCR-cd T cells and CD4 + T cells are subsets of known T cell lineages or whether they constitute distinct lineages require additional experimentation.…”

Section: Visualization Of Il-4 Inducibility + Cells and Changes Assocmentioning

confidence: 99%

“…Three distinct lineages of T cells, the CD1d-restricted NKT cells [5], MHC-II-restricted CD4 + T cells [6,7], and TCR-cd T cells [8], possess the property of TCR-stimulated IL-4 inducibility. As IL-4 is a pleiotropic cytokine that is expected to signal through IL-4R expressed on immune cells as well as many nonimmune cells and tissues [9,10], IL-4 inducibility by T cells that belong to these three distinct T cell lineages is reviewed here.…”

Section: Introductionmentioning

confidence: 99%

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IL-4 inducibility in NKT cells, naïve CD4+ T cells and TCR-γ δ T cells

Chen

Kung

2007

J Biomed Sci

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NKT cells, naïve CD4(+) T cells, and TCR-gammadelta T cells belong to distinct T cell lineages but all express T cell receptors generated through random combinatorial joining of V-(D)-J genes. These distinct lineage T cells also possess the property of promptly activating the IL-4 gene upon T cell receptor stimulation. A comparative accounting of features as they pertain to IL-4 inducibility in these three distinct lineage T cells is provided here.

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CD8+ T cell memory is sustained in mice by hepatic stellate cells

Chen

et al. 2023

Hepatology

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Background and Aims: Long-lasting immunological memory is the ultimate goal of vaccination. Homeostatic maintenance of memory CD8 + cytotoxic T cells (MemCD8TCs) is thought to be mediated by IL-15/IL-15R heterodimer (15HD)-expressing myeloid cells. Nonmyeloid hepatic stellate cells (HSCs) also express 15HD, but their role in maintaining MemCD8TC homeostasis is unknown. Approach and Results:We engineered a genetically engineered mouse in which IL-15R complementary DNA (cDNA) had been inserted in-frame with lecithin-retinol acyltransferase gene and bred onto an IL-15R-KO (15R-KO) genetic background (L15R) that expressed IL-15R in HSCs at normal levels, but not in other liver cells. Outside of the liver of L15R mice, IL-15R expression was found in a number of organs, but not in dendritic cells and macrophages. The low IL-15R expression in the bone marrow (BM) of L15R mice was eliminated by the reconstitution of lethally-irradiated L15R mice with 15R-KO BM to generate L15RC mice. Because MemCD8TC maintenance is mediated by 15HD, not empty IL-15R, 15HD content in L15R mice was determined and found for liver, lung, kidney, and heart. L15R and L15RC mice developed and maintained long-lasting, systemic antigen-specific MemCD8TCs that were efficacious against tumor growth and Listeria monocytogenes infection in an antigen-specific manner. Among the four organs with 15HD content, liver-associated MemCD8TCs were different from those found in the lung, kidney, and heart in two ways: (1) they were quantitatively the most numerous, and (2) they appeared uniquely in the form of clusters in a specialized structure, sinusoidal niches of the liver.

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CD1d-Independent Developmental Acquisition of Prompt IL-4 Gene Inducibility in Thymus CD161(NK1)−CD44lowCD4+CD8− T Cells Is Associated with Complementarity Determining Region 3-Diverse and Biased Vβ2/Vβ7/Vβ8/Vα3.2 T Cell Receptor Usage

Cited by 9 publications

References 102 publications

CD161 defines the subset of FoxP3+ T cells capable of producing proinflammatory cytokines

CD161 defines the subset of FoxP3+ T cells capable of producing proinflammatory cytokines

IL-4 inducibility in NKT cells, naïve CD4+ T cells and TCR-γ δ T cells

CD8+ T cell memory is sustained in mice by hepatic stellate cells

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