CD38 in the nucleus accumbens and oxytocin are related to paternal behavior in mice

Akther, Shirin; Korshnova, Natalia; Zhong, Jing; Liang, Mingkun; Cherepanov, Stanislav M.; Lopatina, Olga; Komleva, Yulia K.; Салмина, А. Б.; Nishimura, Tomoko; Fakhrul, Azam A. K. M.; Hirai, Hirokazu; Kato, Ichiro; Yamamoto, Yasuhiko; Takasawa, Shin; Okamoto, Hiroshi; Higashida, Haruhiro

doi:10.1186/1756-6606-6-41

Cited by 43 publications

(67 citation statements)

References 76 publications

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“…The current and previously published findings suggest that the neural circuitry mediating paternal behavior includes the mPOA, VP and NAcc [16], may be similar to those that mediate maternal behavior as proposed by Numan and his colleagues [18].…”

Section: Discussionsupporting

confidence: 80%

“…However, uniparental male mice that are forced to live together exhibit maternal-like behavior, including providing protection and warmth to offspring [13]. We recently developed a co-housing paradigm to study paternal behavior of the mouse ICR strain [14][15][16]. When mouse sires are continuously housed in the maternal cage with their mates and pups for three to five days prior to and after parturition, they exhibit signs of maternal-like parental care.…”

Section: Introductionmentioning

confidence: 99%

“…We recently reported that central cholinergic cellular signaling [15] and CD38 and oxytocin signaling in the nucleus accumbens (NAcc) [16] are critical for the expression of paternal care. However, it is not yet known if the brain regions responsible for maternal behavior, the medial preoptic area (mPOA), the ventral tegmental area (VTA), the NAcc and the ventral pallidum (VP), also regulate paternal behavior [5,6,17,18].…”

Section: Introductionmentioning

confidence: 99%

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Effects of electrical lesions of the medial preoptic area and the ventral pallidum on mate-dependent paternal behavior in mice

Akther

Fakhrul

Higashida

2014

Neuroscience Letters

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h i g h l i g h t s• The mouse sires displayed mate-dependent paternal behavior.• This parental behavior was disrupted by electrical brain lesions.• The medial preoptic area and ventral pallidum are involved in the paternal behaviors. a r t i c l e i n f o t r a c tIn laboratory animals, less is known about the neural circuits that mediate paternal behavior than those that influence maternal behavior. In mice, we recently reported that when sires are separated with their mate dams from their pups, ultrasound and pheromonal signals from the dams can evoke and initiate maternal-like retrieval behavior in the sires upon reunion with the offspring; this is termed mate-dependent paternal care. We used electrolytic brain lesion (EBL) methods to identify the potential roles of the medial preoptic area (mPOA) and ventral pallidum (VP) regions in regulating paternal care, areas known to be critical for the expression of maternal behavior. Electrolytic lesions of the mPOA or VP disrupted mate-dependent paternal care; latencies to initiate pup retrieval, grooming and crouching were longer in the EBL-treated sires relative to the sham-operated mice. The number of grooming episodes and duration of crouching were also lower in sires with the EBL in both areas. These results indicate that the mPOA and VP regions are essential for mate-dependent paternal care in mice.

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Section: Discussionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of electrical lesions of the medial preoptic area and the ventral pallidum on mate-dependent paternal behavior in mice

Akther

Fakhrul

Higashida

2014

Neuroscience Letters

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“…Further, Brattleboro rats, which are genetically incapable of producing AVP, also show deficits in maternal care evidenced by a lower survival rate of offspring (Wideman and Murphy, 1990). Female and male CD38 knockout mice, which exhibit low central OT levels in comparison to wild-type mice, as mentioned above, also display deficits in parental behavior (i.e., lower rate of pup retrieval and crouching over pups) (Jin et al, 2007; Akther et al, 2013). The re-expression of CD38 (using AAV) in the nucleus accumbens and OT administration in CD38 knockout mice can restore paternal behavior (including retrieval, pup grooming, crouching, and huddling) (Akther et al, 2013).…”

Section: Parental Bondingmentioning

confidence: 99%

Social bonding: regulation by neuropeptides

Lieberwirth

Wang

2014

Front. Neurosci.

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Affiliative social relationships (e.g., among spouses, family members, and friends) play an essential role in human society. These relationships affect psychological, physiological, and behavioral functions. As positive and enduring bonds are critical for the overall well-being of humans, it is not surprising that considerable effort has been made to study the neurobiological mechanisms that underlie social bonding behaviors. The present review details the involvement of the nonapeptides, oxytocin (OT), and arginine vasopressin (AVP), in the regulation of social bonding in mammals including humans. In particular, we will discuss the role of OT and AVP in the formation of social bonds between partners of a mating pair as well as between parents and their offspring. Furthermore, the role of OT and AVP in the formation of interpersonal bonding involving trust is also discussed.

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“…The average litter size of the dams was 13.5 ± 0.67 (n = 30) [22]. Each of the family units, composed of the new sire and dam and their first litter, were experimentally naïve and used once (Figure 1, S1).…”

Section: Methodsmentioning

confidence: 99%

c-Fos expression in the paternal mouse brain induced by communicative interaction with maternal mates

et al. 2014

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BackgroundAppropriate parental care by fathers greatly facilitates health in human family life. Much less is known from animal studies regarding the factors and neural circuitry that affect paternal behavior compared with those affecting maternal behavior. We recently reported that ICR mouse sires displayed maternal-like retrieval behavior when they were separated from pups and caged with their mates (co-housing) because the sires receive communicative interactions via ultrasonic and pheromone signals from the dams. We investigated the brain structures involved in regulating this activity by quantifying c-Fos-immunoreactive cells as neuronal activation markers in the neural pathway of male parental behavior.Resultsc-Fos expression in the medial preoptic area (mPOA) was significantly higher in sires that exhibited retrieval behavior (retrievers) than those with no such behavior (non-retrievers). Identical increased expression was found in the mPOA region in the retrievers stimulated by ultrasonic vocalizations or pheromones from their mates. Such increases in expression were not observed in the ventral tegmental area (VTA), nucleus accumbens (NAcc) or ventral palladium (VP). On the following day that we identified the families of the retrievers or non-retrievers, c-Fos expression in neuronal subsets in the mPOA, VTA, NAcc and VP was much higher in the retriever sires when they isolated together with their mates in new cages. This difference was not observed in the singly isolated retriever sires in new cages. The non-retriever sires did not display expression changes in the four brain regions that were assessed.ConclusionThe mPOA neurons appeared to be activated by direct communicative interactions with mate dams, including ultrasonic vocalizations and pheromones. The mPOA-VTA-NAcc-VP neural circuit appears to be involved in paternal retrieval behavior.

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CD38 in the nucleus accumbens and oxytocin are related to paternal behavior in mice

Cited by 43 publications

References 76 publications

Effects of electrical lesions of the medial preoptic area and the ventral pallidum on mate-dependent paternal behavior in mice

Effects of electrical lesions of the medial preoptic area and the ventral pallidum on mate-dependent paternal behavior in mice

Social bonding: regulation by neuropeptides

c-Fos expression in the paternal mouse brain induced by communicative interaction with maternal mates

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