CD4+-CD25+-TReg-Zellen bei Patienten mit allergischer Rhinitis

Shao-qing, Yan; Yinjian, C.; Zhiqiang, Y.; Ruxin, Z.; Na, C.; Rongming, GE

doi:10.5414/alx01782

2016

DOI: 10.5414/alx01782

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CD4+-CD25+-TReg-Zellen bei Patienten mit allergischer Rhinitis

Yan Shao-qing¹,

C. Yinjian²,

Y. Zhiqiang³

et al.

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Variation of Regulatory T Lymphocytes in the Peripheral Blood of Children with Allergic Rhinitis

Saad

Zahran

Elsayh

et al. 2017

Arch. Immunol. Ther. Exp.

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The studies of T-regulatory (Treg) cells in the pediatric allergic disorders, especially allergic rhinitis (AR), are very few and still far from being elucidated. The aim of this study is to assess the frequencies of CD4CD25Foxp3 (CD4Tregs) and CD8CD25Foxp3 (CD8Tregs) regulatory T lymphocytes in the peripheral blood of children with AR. In fresh whole blood of 60 children with AR and 40 healthy controls, the frequencies of CD4Tregs and CD8Tregs were examined by flow cytometry. The total IgE concentration in the serum was measured. In AR children, the frequencies of CD4Tregs and CD8Tregs were significantly reduced when compared to control group (p = 0.041, p = 0.011, respectively). Moreover, the expressions of Foxp3 in CD4CD25 and CD8CD25 cells were significantly lower in patient group than controls. We found a significant negative correlation between the frequencies of CD4Tregs and the total IgE concentration (p < 0.01). In conclusion, the present study demonstrated that the percentages of CD8Tregs and CD4Tregs T cells were significantly decreased in children with AR. This suggests that decreased Treg cells might represent a defect in the compartment of T-cell population in children with AR. Further studies are warranted to fully appreciate the clinical relevance of Tregs in children with AR.

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Variation of Regulatory T Lymphocytes in the Peripheral Blood of Children with Allergic Rhinitis

Saad

Zahran

Elsayh

et al. 2017

Arch. Immunol. Ther. Exp.

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show abstract

Derp1-modified dendritic cells attenuate allergic inflammation by regulating the development of T helper type1(Th1)/Th2 cells and regulatory T cells in a murine model of allergic rhinitis

Han

Liu

et al. 2017

Molecular Immunology

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CD4+-CD25+-TReg-Zellen bei Patienten mit allergischer Rhinitis

Cited by 2 publications

References 0 publications

Variation of Regulatory T Lymphocytes in the Peripheral Blood of Children with Allergic Rhinitis

Variation of Regulatory T Lymphocytes in the Peripheral Blood of Children with Allergic Rhinitis

Derp1-modified dendritic cells attenuate allergic inflammation by regulating the development of T helper type1(Th1)/Th2 cells and regulatory T cells in a murine model of allergic rhinitis

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