CD4/CD8 Double-negative Mycosis Fungoides: A Case Report and Literature Review

Ito, Ayako; Sugita, Kazunari; Ikeda, Ayano; Yamamoto, Osamu

doi:10.33160/yam.2019.03.021

Cited by 19 publications

(24 citation statements)

References 29 publications

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“…T-cell intracytoplasmic antigen 1 (TIA1) is a cytotoxic molecule constitutively expressed by CD8 + cytotoxic cells, either in their active or resting state [ 47 ]. It has been reported that, in HMF, malignant CD8 + lymphocytes are TIA1 positive [ 16 , 17 , 48 ], whereas malignant CD8 – lymphocytes are TIA1 negative [ 49 ]. However, given that CD8 + cells express TIA1 regardless of whether they are active or resting, this does not reflect an active antitumor immune response.…”

Section: Cancer Immunoediting In Mycosis Fungoidesmentioning

confidence: 99%

Hypopigmented Mycosis Fungoides: Loss of Pigmentation Reflects Antitumor Immune Response in Young Patients

Villarreal

Gantchev

Lagacé

et al. 2020

Cancers

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Hypopigmented mycosis fungoides (HMF) is a form of cutaneous T-cell lymphoma (CTCL), a heterogeneous group of extranodal non-Hodgkin’s lymphomas. HMF has a unique set of defining features that include light colored to achromic lesions, a predilection for darker skin phototypes, an early onset of disease, and predominance of CD8+ T-cells, among others. In the current review, we detail the known pathways of molecular pathogenesis for this lymphoma and posit that an active Th1/cytotoxic antitumor immune response in part explains why this variant is primarily seen in children/adolescents and young adults, who do not exhibit signs of immunosenescence. As a result of this potent cytotoxic response, HMF patients experience mostly favorable overall prognosis, while hypopigmentation may in fact represent a useful surrogate marker of cytotoxic immunity targeting the malignant cells. Understanding the molecular processes behind the specific features that define HMF may lead to improved diagnostic accuracy, personalized prognosis by risk stratification, and improved management of HMF. Moreover, improving our knowledge of HMF may aid our further understanding of other cutaneous lymphomas.

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Section: Cancer Immunoediting In Mycosis Fungoidesmentioning

confidence: 99%

Hypopigmented Mycosis Fungoides: Loss of Pigmentation Reflects Antitumor Immune Response in Young Patients

Villarreal

Gantchev

Lagacé

et al. 2020

Cancers

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“…To our knowledge, this is the first case of an eczematous drug eruption due to clonazepam that was correlated with serum TARC levels. TARC is a T‐helper 2‐type chemokine, and serum TARC levels are related to the disease activities of atopic dermatitis, bullous pemphigoid and MF 1–3 . A recent study showed that serum TARC levels were correlated with blood eosinophil counts in Type 2‐mediated drug eruptions 4 .…”

Section: Figurementioning

confidence: 99%

Correlation between serum thymus and activation‐regulated chemokine levels and eczematous drug eruption following oral challenge test with clonazepam

Yoshïda

Sugita

Tani

et al. 2020

Clin. Exp. Dermatol.

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“…[ 4 ] The infiltrates of T-helper memory lymphocytes in MF lesions are generally found to be positive for CD3, CD4, and CD45RO and negative for CD8 phenotypes via immunohistochemical assays. [ 5 ] In a preliminary, single-center prospective study, CD4 and CD8 co-expression characteristics were found in one-third of patients with MF through conventional immunophenotyping. These patients exhibited slightly lower rates of disease progression compared to patients with conventional CD4+/CD8− MF phenotype.…”

Section: Introductionmentioning

confidence: 99%

CD4/CD8 dual-positive mycosis fungoides

et al. 2020

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Rationale: Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma. It appears as patches, plaques, and tumors depending on the stage of the disease, which presents a chronic progressive course. Compared to CD4 + /CD8 - MF, CD4/CD8 dual-positive MF is an uncommon immune phenotype. Patient Concerns: A 36-year-old male patient presented with dryness and scales on his whole body. Diagnosis: The patient was diagnosed with MF based on results of pathological examination, immunohistochemical staining, and T-cell receptor gene rearrangement test. Interventions: The patient was advised to take an herbal medicine orally twice daily and apply a topical moisturizer after showering. Outcomes: After treatment and follow-up, the patient's symptoms of dryness and scales improved and his condition stabilized. Conclusions: While reviewing the literature, we found no previous reports on the treatment of dual-positive MF with Chinese medicine. In this report, we presented the first case of dual-positive MF successfully treated with Chinese medicine. The results suggest that oral ingestion of herbal medicine may be a feasible method for alleviating clinical symptoms of early stage MF. Therefore, the therapy should be explored for clinical use in the future.

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CD4/CD8 Double-negative Mycosis Fungoides: A Case Report and Literature Review

Cited by 19 publications

References 29 publications

Hypopigmented Mycosis Fungoides: Loss of Pigmentation Reflects Antitumor Immune Response in Young Patients

Hypopigmented Mycosis Fungoides: Loss of Pigmentation Reflects Antitumor Immune Response in Young Patients

Correlation between serum thymus and activation‐regulated chemokine levels and eczematous drug eruption following oral challenge test with clonazepam

CD4/CD8 dual-positive mycosis fungoides

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