2019
DOI: 10.1155/2019/3231696
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CD4+ TSCMs in the Bone Marrow Assist in Maturation of Antibodies against Influenza in Mice

Abstract: The bone marrow (BM) is not only a reservoir of hematopoietic stem cells but a repository of immunological memory cells. Further characterizing BM-resident memory T cells would be helpful to reveal the complicated relationship between the BM and immunological memory. In this study, we identified CD122high stem cell antigen-1 (Sca-1) high B cell lymphoma 2 (Bcl-2) high CD4+ stem cell-like memory T cells (TSCMs) as a distinct memory T cell subset, which preferentially reside in the BM, where they respond vigorou… Show more

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Cited by 4 publications
(6 citation statements)
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“…Cluster 7 is composed of M1-like macrophages that express CD64, F4-80, MHCII, and CX3CR1. Cluster 5 was characterized by CD90.2 + Sca1 + CD45 + , with lower levels of CD44, CD69, and CD86 expression, indicating they could be CD8 + memory T cells or NKT cells ( 54 , 55 ). Because the myeloid panel lacks CD4 or CD8, it is still unclear whether cluster 5 was composed of CD4 or CD8 subsets.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Cluster 7 is composed of M1-like macrophages that express CD64, F4-80, MHCII, and CX3CR1. Cluster 5 was characterized by CD90.2 + Sca1 + CD45 + , with lower levels of CD44, CD69, and CD86 expression, indicating they could be CD8 + memory T cells or NKT cells ( 54 , 55 ). Because the myeloid panel lacks CD4 or CD8, it is still unclear whether cluster 5 was composed of CD4 or CD8 subsets.…”
Section: Resultsmentioning
confidence: 99%
“…tumors appear to be selectively depleted of stem-like CD8 + T cells and NK cells, both important for tumor control when activated. ( 50), ( 51), ( 52 Cluster 5 was characterized by CD90.2 + Sca1 + CD45 + , with lower levels of CD44, CD69 and CD86 expression, indicating they could be CD8 + memory T cells or NKT cells (54), (55). Because the myeloid panel lacks CD4 or CD8, it is still unclear whether the cluster 5 comprised of CD4 or CD8 subsets.…”
Section: Overexpression Of Mmp2 In B16 Cells Accelerates Tumor Growth and Promotes A Protumorigenic Tmementioning
confidence: 99%
“…Immunofluorescence staining was performed as previously described ( Wu et al, 2019b ). Briefly, tumor and animal tissues were fixed with paraformaldehyde, dehydrated, and cleared with a gradient of alcohol solutions and xylene, respectively.…”
Section: Methodsmentioning
confidence: 99%
“…They express stem cell antigen-1 (Sca-1, CD122) and B-cell lymphoma protein-2 (Bcl-2), and they relocate, after their vigorous response to blood-borne antigens, to the BM by adhesion molecules VCAM-1, P-selectin glycoprotein 1, and P-selectin or E-selectin [49]. The natural CD4+ TSCMs in the BM colocalize with VCAM-1+, IL-15+, IL-7+, and CXCL-12+ stromal cells [50]. In contrast to spleen-resident CD4+ TSCMs, the BM resident TSCMs are able to assist in the maturation of antibodies [50].…”
Section: Stem-like Memory T Cells In Bm Parenchymamentioning
confidence: 99%