CD62L− memory T cells enhance T-cell regeneration after allogeneic stem cell transplantation by eliminating host resistance in mice

Zhang, Jifeng; Barefoot, Brice E.; Mo, Wenjian; Deoliveira, Divino; Son, Jessica; Cui, Xiuyu; Ramsburg, Elizabeth; Chen, Benny J.

doi:10.1182/blood-2011-03-342055

Cited by 16 publications

(18 citation statements)

References 42 publications

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“…These data indicated that T cell expansion was severely inhibited in both T EM -like cell and T EM recipients during GVHD at least at the peak of naïve T cell expansion. Because allospecific T EM are able to proliferate and expand in response to alloantigen as indicated in the mixed lymphocyte reaction assay (Figure 3C), the in vivo T cell expansion data suggested that, similar to memory T cells from unprimed donors (22, 23), allospecific T EM also mediated an abortive alloresponse after hematopoietic stem cell transplantation. Cytokine storm is a downstream cascade after T cell activation and clonal expansion during GVHD (24).…”

Section: Resultsmentioning

confidence: 91%

Allospecific CD4+ Effector Memory T Cells Do Not Induce Graft-versus-Host Disease in Mice

Zhang

Deoliveira

et al. 2012

Biology of Blood and Marrow Transplantation

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Section: Resultsmentioning

confidence: 91%

Allospecific CD4+ Effector Memory T Cells Do Not Induce Graft-versus-Host Disease in Mice

Zhang

Deoliveira

et al. 2012

Biology of Blood and Marrow Transplantation

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“…Here we discuss only recent informative updated trials and reports (Table 3); data reported between 2012 and 2013) regarding the promotion of immune reconstitution, particularly in haploidentical transplantation settings [53,65,69,107].…”

Section: Strategies To Improve Immune Reconstitution After Haploidentmentioning

confidence: 99%

Immune Reconstitution after Haploidentical Hematopoietic Stem Cell Transplantation

Chang

Zhao

Huang

2014

Biology of Blood and Marrow Transplantation

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Haploidentical hematopoietic stem cell transplantation (HSCT) offers the benefits of rapid and nearly universal donor availability and has been accepted worldwide as an alternative treatment for patients with hematologic malignancies who do not have a completely HLA-matched sibling or who require urgent transplantation. Unfortunately, serious infections and leukemia relapse resulting from slow immune reconstitution remain the 2 most frequent causes of mortality in patients undergoing haploidentical HSCT, particularly in those receiving extensively T cell-depleted megadose CD34(+) allografts. This review summarizes advances in immune recovery after haploidentical HSCT, focusing on the immune subsets likely to have the greatest impact on clinical outcomes. The progress made in accelerating immune reconstitution using different strategies after haploidentical HSCT is also discussed. It is our belief that a predictive immune subset-guided strategy to improve immune recovery might represent a future clinical direction.

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“…This procedure was performed according to a previously publication from our laboratory [16]. Briefly, BALB/c nude mice were first irradiated with a lethal dose of radiation (8.5 Gy).…”

Section: Methodsmentioning

confidence: 99%

Long-Term In Vivo Imaging of Multiple Organs at the Single Cell Level

et al. 2013

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Two-photon microscopy has enabled the study of individual cell behavior in live animals. Many organs and tissues cannot be studied, especially longitudinally, because they are located too deep, behind bony structures or too close to the lung and heart. Here we report a novel mouse model that allows long-term single cell imaging of many organs. A wide variety of live tissues were successfully engrafted in the pinna of the mouse ear. Many of these engrafted tissues maintained the normal tissue histology. Using the heart and thymus as models, we further demonstrated that the engrafted tissues functioned as would be expected. Combining two-photon microscopy with fluorescent tracers, we successfully visualized the engrafted tissues at the single cell level in live mice over several months. Four dimensional (three-dimensional (3D) plus time) information of individual cells was obtained from this imaging. This model makes long-term high resolution 4D imaging of multiple organs possible.

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CD62L− memory T cells enhance T-cell regeneration after allogeneic stem cell transplantation by eliminating host resistance in mice

Abstract: A major challenge in allogeneic hematopoietic cell transplantation is how to transfer T-cell immunity without causing graftversus-host disease (GVHD). Effector memory T cells (CD62L

Cited by 16 publications

References 42 publications

Allospecific CD4+ Effector Memory T Cells Do Not Induce Graft-versus-Host Disease in Mice

Allospecific CD4+ Effector Memory T Cells Do Not Induce Graft-versus-Host Disease in Mice

Immune Reconstitution after Haploidentical Hematopoietic Stem Cell Transplantation

Long-Term In Vivo Imaging of Multiple Organs at the Single Cell Level

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