CD8‐positive juvenile onset mycosis fungoides: an immunohistochemical and genotypic analysis of six cases

Abstract

These data show that cytotoxic T-cell lymphoma can pursue an indolent course and that cases of CD8-positive MF may be over-represented in childhood.

Outcome in 34 patients with juvenile‐onset mycosis fungoides

“…None of the 45 patients with childhood-onset hypopigmented disease reported in the current series (n ϭ 8) or elsewhere in the literature (n ϭ 37) has experienced progression beyond Stage IB disease. 7,[12][13][14][15][16][17][18][19][20][21][22] This subgroup of hypopigmented childhood-onset MF appears to have an excellent prognosis.…”

“…6,[23][24][25] In a previous study, we found that CD8-positive CTCL patients with juvenile-onset MF appeared to behave in a similar manner to patients with CD4-positive juvenile-onset MF. 22 It has been reported that CD8-positive MF follows a more aggressive course if the neoplastic cells are CD2-negative and CD7-positive. 26 However, none of the patients with a cytotoxic phenotype in the current study had loss of CD2 expression, and only 1 of 12 patients with a cytotoxic phenotype experienced disease progression.…”

WHO-EORTC classification for cutaneous lymphomas

“…In rare cases of otherwise classical, MF a CD4 Ϫ , CD8 ϩ mature T-cell phenotype may be seen. 25,26,54,55 Such cases have the same clinical behavior and prognosis as CD4 ϩ cases, and should not be considered separately. Demonstration of an aberrant phenotype (eg, loss of pan-T-cell antigens such as CD2, CD3, and CD5) is often seen and is an important adjunct in the diagnosis of MF.…”

Rare Skin Tumours in Childhood: Review

“…28,40,41 Histolojik olarak mukozis fungoidesin inflamatuar lezyonları ile aynı özellikleri göstermesine rağmen çocuklarda immünofenotipik olarak ağırlıklı olarak CD4+ T hücrelerinden çok CD8+ T-hücrelerinden oluşur. 42,43 Granülomatöz gevşek deri son derece nadir görülür, papül ve viyole renkli plaklar ile başlayıp gevşek deri kitlelerine ilerler. Lezyonlar eritematöz ve kırışık olarak yaygın şekilde aksiller ve inguinal bölgelerde, erkeklerde daha fazla görü-lür.…”