Cecal Flora of White Rats on Purified Diet and Its Modification by Succinylsulfathiazole

Evenson, Adelaide E.; McCoy, Elizabeth; Geyer, Beverly Ransone; Elvehjem, C. A.

doi:10.1128/jb.51.4.513-521.1946

Cited by 14 publications

(5 citation statements)

References 14 publications

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“…First, this study focused on the effects of CFD diet on glucose and lipid metabolism and cognitive function in female mice, but it could not explore gender difference. Second, succinylsulfathiazole intake was reported to modify the intestinal microbiome, including reduction of Lactobacillus and Coliform and upregulation of Enterococci and Yeastlike organisms in Sprague-Dawley rats [ 50 ]. Changes in intestinal microbiome have been closely associated with glucose and lipid metabolism.…”

Section: Discussionmentioning

confidence: 99%

Chronic folate deficiency induces glucose and lipid metabolism disorders and subsequent cognitive dysfunction in mice

Zhao

Yuan

et al. 2018

PLoS ONE

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Previous studies have shown that folate levels were decreased in patients with type 2 diabetes (T2D) and further lowered in T2D patients with cognitive impairment. However, whether folate deficiency could cause T2D and subsequent cognitive dysfunction is still unknown. The present study aimed to explore the effects of chronic folate deficiency (CFD) on glucose and lipid metabolism and cognitive function in mice. Seven-week-old mice were fed with either a CFD or control diet for 25 weeks. Serum folate was significantly reduced, whereas serum total homocysteine was significantly increased in the CFD group. Moreover, CFD induced obesity after a 6-week diet treatment, glucose intolerance and insulin resistance after a 16-week-diet treatment. In addition, CFD reduced the hepatic p-Akt/Akt ratio in response to acute insulin administration. Moreover, CFD increased serum triglyceride levels, upregulated hepatic Acc1 and Fasn mRNA expression, and downregulated hepatic Cd36 and ApoB mRNA expression. After a 24-week diet treatment, CFD induced anxiety-related activities and impairment of spatial learning and memory performance. This study demonstrates that folate deficiency could induce obesity, glucose and lipid metabolism disorders and subsequent cognitive dysfunction.

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Section: Discussionmentioning

confidence: 99%

Chronic folate deficiency induces glucose and lipid metabolism disorders and subsequent cognitive dysfunction in mice

Zhao

Yuan

et al. 2018

PLoS ONE

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“…SST is considered to be bacteriostatic since it does not actively kill bacterial cells (Patrick, 1995; Sepehr et al, 2003). In the rat, a 28-day treatment with SST substantially reduces the number of gut coliforms and lactobacteria (2- and 100-fold, respectively), which is compensated for by increases in enterococci and yeastlike forms (Evenson et al, 1946). The exposure to SST did not alter folate metabolism in the dams, given that homocysteine levels in exposed dams were similar to those in non-exposed dams.…”

Section: Discussionmentioning

confidence: 99%

Maternal gut and fetal brain connection: Increased anxiety and reduced social interactions in Wistar rat offspring following peri-conceptional antibiotic exposure

Degroote

Hunting

Baccarelli

et al. 2016

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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“…However, their results indicated that the cecum was not the only location for the synthesis of vitamin K since cecectomized rats on a ration deficient only in vitamin K grew well and evidenced no vitamin K deficiency unless one per cent sulfasuxidine was incorporated in the ration; rats with intact ceca on the same ration with sulfasuxidine evidenced no vitamin K deficiency. These results are indicative of the synthesis of vitamin K by bacteria other than those of the coliform group since numerous workers have shown that certain sulfonamides inhibit proliferation of this group of micro6rganisms (25,32,53,56,62,66,78). Schweigert, et al (88) found that cecectomized rats on complete synthetic rations grew as well as the unoperated controls.…”

Section: Intestinal Micro0rgani5m3mentioning

confidence: 81%

“…Evenson, et at. (25) found not only the coliform flora to be affected by use of sulfathiazole in rat rations, but that lactobacilli also were reduced in numbers by the presence of the drug.…”

Section: ]mentioning

confidence: 93%

Some Considerations of the Biological Importance of Intestinal Microörganisms 1

Johansson¹,

Sarles²

1949

Bacteriological Reviews

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The relationship of intestinal bacteria to the well-being of the host has been of general interest for over sixty years. Despite numerous studies conducted to determine the r6les of these organisms in health and disease, their functions are not completely understood. The kinds of bacteria found in the digestive tract and their distribution have been extensively studied in many animal species including man. It is known that the ecology of the intestines is very complex; changes which have been found to occur in the numbers and kinds of microorganisms in the intestines are difficult to explain. Nutritionists, bacteriologists and physicians now tend to regard intestinal microorganisms as sources of nutrilites indispensable to the animal host, particularly if the diet is poorly balanced; previously these organisms had been considered only as potential causative agents of gastro-intestinal disturbances. Many of the early investigators considered intestinal bacteria as saprophytes whose putrefactive metabolic products were harmful. Later, it was realized that there are two main types of intestinal bacteria: acid-producing or saccharolytic species, and proteolytic species. The latter group always has been considered harmful or undesirable, but their true significance is not settled. Acidproducing species, on the contrary, always have been deemed desirable for proper conditions in the intestinal tract. Recently, with the help of the rapid advances made in the field of nutrition, considerable evidence has been accumulated which indicates that intestinal bacteria are important in supplying essential growth substances to the host, although it is not certain that they are indispensable. Earlier work now can be re-evaluated with more assurance of drawing valid conclusions. However, there still exists a variety of viewpoints which may eventually be consolidated when more basic work is accomplished. Probably the first observation of intestinal micro6rganisms was made by Leeuwenhoek (17) in about the year 1674. Many of the organisms he saw with his simple microscope no doubt were bacteria. Two centuries later, Escherich initiated what is considered to be the first comprehensive study of intestinal bacteria in human infants, and laid the foundlation for future work in this field. THE RULES OF INTESTINAL BACTERIA The present tendency of modern nutritionists to think of intestinal microorganisms in terms of their nutritional importance to their host is based on a I Published with the permission of the Director of the Wisconsin Agricultural Experiment Station.

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Cecal Flora of White Rats on Purified Diet and Its Modification by Succinylsulfathiazole

Cited by 14 publications

References 14 publications

Chronic folate deficiency induces glucose and lipid metabolism disorders and subsequent cognitive dysfunction in mice

Chronic folate deficiency induces glucose and lipid metabolism disorders and subsequent cognitive dysfunction in mice

Maternal gut and fetal brain connection: Increased anxiety and reduced social interactions in Wistar rat offspring following peri-conceptional antibiotic exposure

Some Considerations of the Biological Importance of Intestinal Microörganisms 1

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