Cell-mediated immunity to measles virus in subacute sclerosing panencephalitis.

Yamanaka, Tatsuru; Chiba, Shunzo; Nakao, Tooru; Okabe, Nobuhiko; Takahashi, Naohiko; Saito, S; Kitayama, T; MISHIMA, HIROSHI; KONNO, KANAHIRO; Fujiwara, Kyoji

doi:10.1620/tjem.122.175

Cited by 5 publications

(3 citation statements)

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“…Peripheral blood lymphocytes from SSPE patients were investigated using a target cell colony inhibition method, with a measles antibody. 24 Lymphocytes of two SSPE patients were found to undergo specific destruction while no significant lymphocytotoxicity was observed in the lymphocytes of the other two patients, indicating that cellular immunity could be heterogeneous in SSPE patients. 24 In a study by Mitrokhina and Lebenzon, 25 the cellular immune response of seven SSPE patients aged 4 -12 years was compared with that of healthy children of similar ages and genders.…”

Section: Discussionmentioning

confidence: 89%

“…24 Lymphocytes of two SSPE patients were found to undergo specific destruction while no significant lymphocytotoxicity was observed in the lymphocytes of the other two patients, indicating that cellular immunity could be heterogeneous in SSPE patients. 24 In a study by Mitrokhina and Lebenzon, 25 the cellular immune response of seven SSPE patients aged 4 -12 years was compared with that of healthy children of similar ages and genders. Patients with SSPE showed a decreased total T lymphocyte number, active T lymphocyte sub-population and suppressor T lymphocytes.…”

Section: Discussionmentioning

confidence: 89%

“…23 This finding was suggested to be related to the progressive nature of the condition, 23 however, as the stage of the condition showed a tendency to progress, the CSF/serum measles antibody ratio also increased, and these findings were interpreted to mean that IgG was locally synthesized in SSPE patients. 23 In a study by Yamanaka et al, 24 the specific cellular and humoral immune responses against measles virus in four patients with SSPE were assessed. Peripheral blood lymphocytes from SSPE patients were investigated using a target cell colony inhibition method, with a measles antibody.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of Lymphocyte Subgroups in Children with Subacute Sclerosing Panencephalitis

et al. 2009

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The aetiology of subacute sclerosing panencephalitis (SSPE) remains to be fully elucidated, although it follows infection with a hypermutant defective M-protein measles virus. This study analysed peripheral blood lymphocyte subgroups to determine their role in the pathophysiology of SSPE. It included 22 children with SSPE aged 2 - 15 years (patient group) and 22 age- and gender-matched healthy children (control group). In children < 6 years old, there were no statistically significant differences between the two groups in the proportions of lymphocytes expressing the surface markers CD3, CD8, CD19 or CD16/56, or in CD4/CD8 ratio. The proportion of CD4(+) lymphocytes in SSPE patients < 6 years of age was significantly lower compared with the control group. In children >or= 6 years old, there were no significant differences in the lymphocyte subgroups. In conclusion, these findings suggest that a low CD4(+) lymphocyte count might be responsible for SSPE in younger children.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 89%