“…Interestingly, the ability of cell-membrane mimics, either empty or drug-loaded, with NPs core or not, to display the same membrane receptors as the mother cells, makes them a potential arm to attach toxins, viruses, membrane proteins, or signaling molecules and divert them away from their targets, giving an emerging class of biomimetics termed nanodecoys or nanosponge [ 79 , [83] , [84] , [85] ]. Further, hybridization and emerging genetic engineering technologies can be employed to quantitively and qualitatively change their antigenic profile [ 77 ].…”
Section: Implications Of Inflammation In Covid-19 Therapies and Drug ...mentioning
“…Interestingly, the ability of cell-membrane mimics, either empty or drug-loaded, with NPs core or not, to display the same membrane receptors as the mother cells, makes them a potential arm to attach toxins, viruses, membrane proteins, or signaling molecules and divert them away from their targets, giving an emerging class of biomimetics termed nanodecoys or nanosponge [ 79 , [83] , [84] , [85] ]. Further, hybridization and emerging genetic engineering technologies can be employed to quantitively and qualitatively change their antigenic profile [ 77 ].…”
Section: Implications Of Inflammation In Covid-19 Therapies and Drug ...mentioning
“…Due to its superiorly deeper tissue penetration, SDT has been developed as a potential alternative to traditional cancer therapy ( 19 ). Considering the fact that current SDT agents often show a low SDT efficacy due to insufficient tumor accumulation, a bioinspired membrane-coated nanoplatform would overcome these limitations ( 20 ). Moreover, SDT can also be used to activate the antitumor immune response and demonstrate a superior synergistic effect with immunotherapy.…”
Section: Cell Membrane Coating Nanoplatform In the Therapy Of Cancermentioning
Immunotherapy can effectively activate the immune system and reshape the tumor immune microenvironment, which has been an alternative method in cancer therapy besides surgery, radiotherapy, and chemotherapy. However, the current clinical outcomes are not satisfied due to the lack of targeting of the treatment with some unexpected damages to the human body. Recently, cell membrane-based bioinspired nanoparticles for tumor immunotherapy have attracted much attention because of their superior immune regulating, drug delivery, excellent tumor targeting, and biocompatibility. Together, the article reviews the recent progress of cell membrane-based bioinspired nanoparticles for immunotherapy in cancer treatment. We also evaluate the prospect of bioinspired nanoparticles in immunotherapy for cancer. This strategy may open up new research directions for cancer therapy.
“…With the universal Bio‐MVs extraction mentioned here, almost all natural membrane proteins can bionically express on the surface to act as biomimetic nanodecoys for pathogen clearance and a pattern platform to study their interactions. [ 68 , 76 ]…”
Section: Multi‐functionalities Of Genetically Engineered Bio‐mvsmentioning
Benefiting from the blooming interaction of nanotechnology and biotechnology, biosynthetic cellular membrane vesicles (Bio-MVs) have shown superior characteristics for therapeutic transportation because of their hydrophilic cavity and hydrophobic bilayer structure, as well as their inherent biocompatibility and negligible immunogenicity. These excellent cell-like features with specific functional protein expression on the surface can invoke their remarkable ability for Bio-MVs based recombinant protein therapy to facilitate the advanced synergy in poly-therapy. To date, various tactics have been developed for Bio-MVs surface modification with functional proteins through hydrophobic insertion or multivalent electrostatic interactions. While the Bio-MVs grow through genetically engineering strategies can maintain binding specificity, sort orders, and lead to strict information about artificial proteins in a facile and sustainable way. In this progress report, the most current technology of Bio-MVs is discussed, with an emphasis on their multi-functionalities as "tailorable shells" for delivering bio-functional moieties and therapeutic entities. The most notable success and challenges via genetically engineered tactics to achieve the new generation of Bio-MVs are highlighted. Besides, future perspectives of Bio-MVs in novel bio-nanotherapy are provided.
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