Cell Resistant Peptidomimetic Poly (2‐ethyl‐2‐oxazoline) Coatings Developed by Low Pressure Inductively Excited Pulsed Plasma Polymerization for Biomedical Purpose

Abstract

http://www.interscience.wiley.com/International audienceIn the present work, for the first time, nano-thick peptidomimetic coatings were developedusing a LP inductively excited pulsed plasma polymerization of 2-ethyl-2-oxazoline (ppEtOz) tocontrol the cell-surface interactions for biological applications. The different ppEtOz coatedsurfaces were investigated by FTIR-ATR, XPS, Ellipsometric, and WCA analysis. Using Gaussiandeconvolution method for IR spectra, we compared the modifications obtained in the chemicalcompositions for ppEtOz coated samples obtained under different plasma parameters. It wasfound that the amide I/amide II ratios decreasedas the effective plasma power increased, which inturn decreased the surface hydrophilicity forppEtOz coatings. Cell repellent properties of theppEtOz coatings deposited at Peff¼1W and 2.5Wwere achieved

Deposition of 2‐oxazoline‐based plasma polymer coatings using atmospheric pressure helium plasma jet

“…It is anticipated that low degree of polymerisation would lead to a reduction in the plasma film crosslinking and poor adhesion to the substrate. This scenario was in good agreement with the findings from other studies where low powers were applied during plasma polymerisation of OX precursors . This is also valid for plasma processes of other precursors …”

“…There are parameters in each technique that can influence the final quality of the deposited plasma coating. The plasma coatings presented in this study, which are obtained by atmospheric pressure plasma jet tend to be more oxidised compared with those obtained by vacuum plasmas . This can be explained by the fact that the plasma jet was running with helium in an open air environment, which results in a higher oxidation of the precursor during the plasma polymerisation process.…”

“…In addition, it was found that those coatings are capable of reacting with carboxylic acid functionalised biomolecules. Due to the potential of this highly versatile coatings, this example was soon followed by others . Bhatt et al developed nanoscale Ox‐based plasma coatings using low pressure inductively excited pulsed plasma polymerisation of 2‐ethyl‐2‐oxazoline to study cell‐surface interactions for biological applications.…”

“…Due to the potential of this highly versatile coatings, this example was soon followed by others . Bhatt et al developed nanoscale Ox‐based plasma coatings using low pressure inductively excited pulsed plasma polymerisation of 2‐ethyl‐2‐oxazoline to study cell‐surface interactions for biological applications. Further, Zanini et al investigated the adhesion, chemistry and reactivity of low‐pressure plasma polymerised 2‐ethyl‐2‐oxazoline on different substrates under various plasma parameters.…”

Plasma Polymerization of 3‐Aminopropyltrietoxysilane (APTES) by Open‐Air Atmospheric Arc Plasma Jet for In‐Line Treatments

“…This value is in good agreement with the work of Lecoq et al but different from the monomer (1590 cm −1 ). The two peaks at 1624 and 1663 cm −1 correspond, respectively, to the so‐called amide I and amide II bands and the peak at 1707 cm −1 could be attributed to carbonyl groups (CO). From 3200 to 3500 cm −1 , The N–H stretching absorption cannot be differentiated from the O–H stretching which are both prominent in this range.…”