Cell therapy in diabetes: current progress and future prospects

Wang, Ying; Hai, Tang; Liu, Lei; Z, Liu; Zhou, Qi

doi:10.1007/s11434-015-0844-6

Cited by 5 publications

(5 citation statements)

References 84 publications

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“…Poor management of diabetes leads to microvascular and macrovascular complications including cardiovascular disease, nephropathy, retinopathy, and peripheral 21,22 neuropathy . A frequently overlooked complication 23 of diabetes is diabetes-related foot ulcers (DFU) .…”

Section: Annals Of King Edward Medical Universitymentioning

confidence: 99%

Type 2 Diabetes Mellitus(T2DM) in Pakistan: Prevalence, Trends and Management Strategies

Aslam¹,

Suhail²,

Sajid³

et al. 2022

Annals KEMU

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The rising incidence of diabetes has become one of the major health problems worldwide. It is especially overburdening low-income countries like Pakistan which ranks 4th in diabetes prevalence. The purpose of this review article is to analyze the current approach to diabetes management in Pakistan and to highlight its deficiencies. It also discusses the future strategies that can help Pakistan to reduce the rising disease burden. Information was collected from the publications which were searched on 'Google scholar' and 'PubMed'. The latest data provided by IDF has shown diabetes prevalence in Pakistan to be 17.1% in 2019; 148% higher than previous reporting. The major obstacles in the effective management of diabetes are lack of resources, societal barriers and patient related issues. In order to reduce the load of diabetes, combined efforts of government, health care professionals and patients are required. In future, diabetes education of the patients as well as HealthCare providers, use of telemedicine for the management of chronic diseases and concept of precision medicine can be applied to decrease diabetes burden in Pakistan.

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Section: Annals Of King Edward Medical Universitymentioning

confidence: 99%

Type 2 Diabetes Mellitus(T2DM) in Pakistan: Prevalence, Trends and Management Strategies

Aslam¹,

Suhail²,

Sajid³

et al. 2022

Annals KEMU

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“…Single cell tells the developmental story Stem cells are undifferentiated cells that retain the ability to self-renew and differentiate into specialized cells, offering a promising resource to generate requisite cell types in regenerative medicine [1,2]. Haematopoietic stem cells (HSCs) can differentiate into entire mature blood lineages, sitting at the apex of the haematopoietic hierachy and playing a key role in the long-term maintenance and stabilization of mammalian blood system functions [3,4].…”

Section: News and Viewsmentioning

confidence: 99%

Single cell tells the developmental story

Zhan

2016

Science Bulletin

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“…There are two types of diabetes mellitus. In type 1 diabetes, an autoimmune disorder, insulin‐producing cells are attacked by the immune system, whereas in type 2 diabetes, insufficient insulin is produced by the β cells and/or other cells exhibit insulin resistance (Wang, Hai, Liu, & Zhou, 2015). Current treatments are insulin injection and islet transplantation.…”

Section: Introductionmentioning

confidence: 99%

Insulin production from hiPSC‐derived pancreatic cells in a novel wicking matrix bioreactor

Amini

Paluh

Xie

et al. 2020

Biotech & Bioengineering

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Clinical use of pancreatic β islets for regenerative medicine applications requires mass production of functional cells. Current technologies are insufficient for large‐scale production in a cost‐efficient manner. Here, we evaluate advantages of a porous cellulose scaffold and demonstrate scale‐up to a wicking matrix bioreactor as a platform for culture of human endocrine cells. Scaffold modifications were evaluated in a multiwell platform to find the optimum surface condition for pancreatic cell expansion followed by bioreactor culture to confirm suitability. Preceding scale‐up, cell morphology, viability, and proliferation of primary pancreatic cells were evaluated. Two optimal surface modifications were chosen and evaluated further for insulin secretion, cell morphology, and viable cell density for human‐induced pluripotent stem cell‐derived pancreatic cells at different stages of differentiation. Scale‐up was accomplished with uncoated, amine‐modified cellulose in a miniature bioreactor, and insulin secretion and cell metabolic profiles were determined for 13 days. We achieved 10‐fold cell expansion in the bioreactor along with a significant increase in insulin secretion compared with cultures on tissue culture plastic. Our findings define a new method for expansion of pancreatic cells a on wicking matrix cellulose platform to advance cell therapy biomanufacturing for diabetes.

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Cell therapy in diabetes: current progress and future prospects

Cited by 5 publications

References 84 publications

Type 2 Diabetes Mellitus(T2DM) in Pakistan: Prevalence, Trends and Management Strategies

Type 2 Diabetes Mellitus(T2DM) in Pakistan: Prevalence, Trends and Management Strategies

Single cell tells the developmental story

Insulin production from hiPSC‐derived pancreatic cells in a novel wicking matrix bioreactor

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