Cellular damage and recovery of the early developing mouse eye following low dose irradiation. II. X-Rays on day 9 of gestation

Balla, I; Michel, Chantal; Fritz-Niggli, H

doi:10.1007/bf01960648

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Cellular damage and recovery of the early developing mouse eye following low dose irradiation. II. X-Rays on day 9 of gestation

1983

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Mouse embryos on day 9 of gestation were exposed in utero to 90 rad X-rays. At different time intervals after treatment the eye primordia were examined for cell death. The irradiation caused an altered necrosis pattern compared with day 8, and massive cell killing during a limited time period. The rapid recovery from the pronounced damage points to a high restitution efficiency of the involved tissue.

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Cellular damage and recovery of the early developing mouse eye following low dose irradiation. II. X-Rays on day 9 of gestation

1983

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Radiation embryology

Michel

1989

Experientia

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Prenatal development, characterized by intensive cell proliferation, cell differentiation and cell migration, shows a high radiosensitivity. Therefore, radiation exposure of embryos and fetuses is of great concern for radiological protection and human health. Irradiation during gestation can cause death, growth disorders, malformations, functional impairment and malignant diseases in childhood. These effects are strongly dependent on the developmental stage at exposure and on the radiation dose. The first trimester of pregnancy is regarded as the period with the highest risk for malformation and cancer induction. The developing nervous system shows a special susceptibility to ionizing radiation over a long period and is therefore of great significance for risk estimation. Knowledge about radiation effects on prenatal development has been derived from animal experimentation and from the exposure of human embryos. There is evidence that doses between 1 and 10 cGy may lead to developmental anomalies and that the radiation response can be modified by additional factors.

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Postimplantation Defects in Development following Ionizing Irradiation

Konermann

1987

Advances in Radiation Biology

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Cellular damage and recovery of the early developing mouse eye following low dose irradiation. II. X-Rays on day 9 of gestation

Cited by 5 publications

References 11 publications

Cellular damage and recovery of the early developing mouse eye following low dose irradiation. II. X-Rays on day 9 of gestation

Cellular damage and recovery of the early developing mouse eye following low dose irradiation. II. X-Rays on day 9 of gestation

Radiation embryology

Postimplantation Defects in Development following Ionizing Irradiation

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