Cellular Uptake and Antitumor Activity of DOX-hyd-PEG-FA Nanoparticles

Ye, Weiliang; Du, Jiangbo; Zhang, Bang-Le; Ren, Nanqi; Song, Yanfeng; Mei, Qibing; Zhao, Ming; Zhou, Siyuan

doi:10.1371/journal.pone.0097358

Cited by 36 publications

(31 citation statements)

References 41 publications

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“…Consistently, several drugs have conducted toward tumor tissues through various FA-conjugated NPs (Fig. 2) [8]. In here, we summarize the recent advances regarding the use of folateconjugated NPs in cancer therapy.…”

Section: Introductionmentioning

confidence: 65%

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Folate-conjugated nanoparticles as a potent therapeutic approach in targeted cancer therapy

et al. 2015

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The selective and efficient drug delivery to tumor cells can remarkably improve different cancer therapeutic approaches. There are several nanoparticles (NPs) which can act as a potent drug carrier for cancer therapy. However, the specific drug delivery to cancer cells is an important issue which should be considered before designing new NPs for in vivo application. It has been shown that cancer cells over-express folate receptor (FR) in order to improve their growth. As normal cells express a significantly lower levels of FR compared to tumor cells, it seems that folate molecules can be used as potent targeting moieties in different nanocarrier-based therapeutic approaches. Moreover, there is evidence which implies folate-conjugated NPs can selectively deliver anti-tumor drugs into cancer cells both in vitro and in vivo. In this review, we will discuss about the efficiency of different folate-conjugated NPs in cancer therapy.

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Section: Introductionmentioning

confidence: 65%

“…As chitosan is soluble in acid condition, it can be applied for drug delivery in an acidic environment [141,8]. In addition to pH, degree of deacetylation, molecular weight, and ionic strength of the solution can potently affect the chitosan solubility [142].…”

Section: Chitosan Nanoparticlesmentioning

confidence: 99%

Folate-conjugated nanoparticles as a potent therapeutic approach in targeted cancer therapy

et al. 2015

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“…[36,65,66] For instance, Dox has been coupled to poly(ethylene glycol) (PEG)-folic acid conjugates to generate hydrophobically modified PEG derivatives that self-assembled into nanoparticles, which showed an enhanced Dox release at pH 5 as compared to pH 7.4. [10] Instead of using the hydrazone bond to couple the drug to a polymer carrier, this pH sensitive motif can also be used to connect the hydrophobic and hydrophilic segments of amphiphiles that are designed to self-assemble into poly mer micelles or nanoparticles. Cleaving the hydrazone bond in the endolysosomal compartments leads to dissociation of these nanoparticles and concomitant release of the entrapped drug.…”

Section: Functionality Examplesmentioning

confidence: 99%

“…[9] The decoration of nanoparticles, micelles, and linear polymers with folic acid (FA) has been shown to result in enhanced intracellular accumulation in folate positive cell lines as compared to the receptornegative cells. [9][10][11] The α v β 3 integrin is another receptor that is frequently targeted and exploited to enhance cellular internalization by decorating delivery systems with the arginine-glycine-aspartic acid tripeptide ligand. [12][13][14] A third example of a receptor that is exploited for tumor targeting is the epidermal growth factor receptor (EGFR), which is generally overexpressed and therefore used in the treatment of neck cancer, glioblastoma, and lung adenocarcinoma.…”

Section: Introductionmentioning

confidence: 99%

Controlling and Monitoring Intracellular Delivery of Anticancer Polymer Nanomedicines

Battistella

Klok

2017

Macromolecular Bioscience

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Polymer nanomedicines are very attractive to improve the delivery of chemotherapeutics. Polymer conjugates and other polymer‐based nanocarriers allow to increase plasma half‐life and drug bioavailability and can also be guided toward tumors using passive and active targeting strategies. Since many chemotherapeutics act on targets that are located in well‐defined subcellular compartments, other important factors that contribute to an efficient therapy include cellular internalization and subsequent intracellular trafficking of the polymer nanomedicines and/or its payload to the appropriate organelle in the cytoplasm. This article provides an overview of the different approaches that have been developed to control intracellular delivery of polymer nanomedicines and discusses the different techniques that can be used to monitor these processes.

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“…These properties have made FA one of the most popular ligands for targeted drug delivery. Actually, the unique properties of FA enable it to be near ideal vector for targeted liposomes, nanoparticles, quantum dots (Syu et al 2012;Ye et al 2014;Parveen and Sahoo 2010;Suriamoorthy et al 2010;Chattopadhyay et al 2013). This approach offers an opportunity to significantly enhance the efficacy of anticancer drugs.…”

Section: Introductionmentioning

confidence: 99%

In vitro anticancer activity of folate-modified docetaxel-loaded PLGA nanoparticles against drug-sensitive and multidrug-resistant cancer cells

et al. 2019

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Background: Poly(lactic-co-glycolic acid) (PLGA) is a biodegradable and biocompatible polymer which is widely used as a matrix to incorporate therapeutic agents. The anticancer activity of targeted folate-modified docetaxel-loaded PLGA nanoparticles (F-NP-Doc) was studied in vitro. Methods: Nanoparticles were prepared by a single-emulsion solvent-evaporation technique and characterized by physico-chemical methods. Cell survival was measured by the MTT assay and the sulforhodamine B assay. Folate receptor α expression, particle uptake and apoptosis were assessed by flow cytometry. Results: Folate-modified docetaxel-loaded PLGA nanoparticles showed high anticancer activity in vitro against HeLa cervical carcinoma cells and MCF7 breast adenocarcinoma cells overexpressing folate receptors. Targeted F-NP-Doc nanoparticles were more active compared to free docetaxel and non-targeted NP-Doc nanoparticles; in contrast, the activity of targeted nanoparticles against human fibroblasts (negative control) was significantly lower. F-NP-Doc particles, like free docetaxel, induced apoptosis in cancer cells. F-NP-Doc, but not unmodified docetaxel-loaded PLGA nanoparticles, reversed multidrug resistance of MCF7 R breast adenocarcinoma cells. High antitumor activity of F-NP-Doc has also been proven in in vivo experiments. Conclusions: The summarized experimental data brought us to the conclusion that the incorporation of docetaxel into the targeted PLGA nanoparticles dramatically improves its selectivity against cancer cells.

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Cellular Uptake and Antitumor Activity of DOX-hyd-PEG-FA Nanoparticles

Cited by 36 publications

References 41 publications

Folate-conjugated nanoparticles as a potent therapeutic approach in targeted cancer therapy

Folate-conjugated nanoparticles as a potent therapeutic approach in targeted cancer therapy

Controlling and Monitoring Intracellular Delivery of Anticancer Polymer Nanomedicines

In vitro anticancer activity of folate-modified docetaxel-loaded PLGA nanoparticles against drug-sensitive and multidrug-resistant cancer cells

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