Cenocladamide, a dihydropyridone alkaloid from Piper cenocladum

Synergistic Effects of Amides from Two Piper Species on Generalist and Specialist Herbivores

“…This shrub is defended by a combination of Piper amides and a mutualism with Pheidole bicornis Forel ants. Plants uninhabited by ants increase amide production by at least a factor of three (Dodson et al, 2000;Dyer et al, 2001). Piper cenocladum contains two imides and an amide at high concentrations (total amide content can be as high as 3.8% dry weight): 4′-desmethylpiplartine (0.18% dry weight with an ant colony and 0.45% without ants), piplartine (0.14% with ants and 0.58% without ants), and cenocladamide (0.09% with ants and 0.33% without ants, Dodson et al, 2000).…”

“…Plants uninhabited by ants increase amide production by at least a factor of three (Dodson et al, 2000;Dyer et al, 2001). Piper cenocladum contains two imides and an amide at high concentrations (total amide content can be as high as 3.8% dry weight): 4′-desmethylpiplartine (0.18% dry weight with an ant colony and 0.45% without ants), piplartine (0.14% with ants and 0.58% without ants), and cenocladamide (0.09% with ants and 0.33% without ants, Dodson et al, 2000). Other experiments have demonstrated that these Piper amides deter arthropods and act synergistically against some herbivores (Dyer et al, 2003(Dyer et al, , 2004b.…”

“…Piper imperiale Imides Before initiating experiments, we quantified the imide concentrations in fully expanded new leaves of 39 individual P. imperiale shrubs, using methods previously described by Dodson et al (2000). Leaves were collected at 39 different sites, spread evenly across the forest at La Selva Biological Station, Heredia province, Costa Rica.…”

Flavonas, lignanas e terpeno de Piper umbellata (Piperaceae)

“…1 A grande maioria de suas espécies produz frutos do tipo espigas com grande quantidade de sementes que possuem síndrome de dispersão zoocó-rica, sendo muito freqüente a dispersão por morcegos. 2 Espécies de Piperaceae têm sido utilizadas na alimentação (como condimento -Piper nigrum), 3 como inseticidas 4 e, também, na medicina tradicional devido ao acúmulo de diferentes classes de metabólitos biologicamente ativos, tais como fenilpropanóides, 5 lignanas/neolignanas, 6-10 pironas, 11 amidas alífáticas e aromáticas, [12][13][14] alcalóides, 15 policetídeos 16 e cromenos, [17][18][19][20][21][22] além de outros metabólitos de biossíntese mista. 7,23,24 As espécies de Piperaceae estão sendo subdivididas em quatro gêneros, 25 sendo que os mais abundantes são Peperomia Ruiz e Pavon, com aproximadamente 1700 espécies 26 e Piper L., com cerca de 2000 espécies.…”

Estudos de metabolismo in vitro de produtos naturais: biotransformação microbiana da piplartina

“…Diante dessas atividades, a piplartina é considerada promissora para o desenvolvimento de novos fármacos anticancerígenos (BEZERRA et al, 2013 DODSON et al, 2000;FACUNDO et al, 2005;DUH e WU, 1990;BRAZ-FILHO et al, 1981;KIJJOA et al, 1982;NAVICKIENE et al, 2000). Essas substâncias também apresentam atividades biológicas, como citotoxicidade frente a células tumorais, leshimanicida e antifúngica.…”