1981
DOI: 10.1002/med.2610010405
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Central actions of β‐adrenoceptor blocking drugs in man

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Cited by 54 publications
(29 citation statements)
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“…The role of these factors in each individual case is difficult to evaluate, because the literature on this topic is limited. The liposolubility, pKa and the extent of protein binding govern the rate and extent of penetration of drugs into CSF (Conant et al, 1989;Cruickshank & Prichard, 1988;Patel & Turner, 1981). Studies of lipophilicity and CNS-related effects of various ,B-adrenoceptor blocking agents, however, have not revealed any clear correlation (Hoffman & Lefkowitz, 1990).…”
Section: Discussionmentioning
confidence: 99%
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“…The role of these factors in each individual case is difficult to evaluate, because the literature on this topic is limited. The liposolubility, pKa and the extent of protein binding govern the rate and extent of penetration of drugs into CSF (Conant et al, 1989;Cruickshank & Prichard, 1988;Patel & Turner, 1981). Studies of lipophilicity and CNS-related effects of various ,B-adrenoceptor blocking agents, however, have not revealed any clear correlation (Hoffman & Lefkowitz, 1990).…”
Section: Discussionmentioning
confidence: 99%
“…It should be noted, however, that propranolol as well as the other drugs, can produce effects via mechanisms unrelated to 3-receptor functions, e.g. by blocking central 5-HT-receptors or by interacting with brain lipids (Conant et al, 1989;Cruickshank & Prichard, 1988;Kostis & Rosen, 1987;Patel & Turner, 1981).…”
Section: Discussionmentioning
confidence: 99%
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“…These include depression (Waal-Manning, 1967), sleep disturbance (Betts & Alford, 1982) and psychosis (Fraser & Carr, 1976). There have also been reports describing deficits in cognitive function (Patel & Turner, 1981;Salem & McDevitt, 1983) including memory (Solomon et al, 1983;Hartley et al, 1983). Angiotensin-converting enzyme inhibitors like enalapril reduce blood pressure by a mechanism unrelated to that of 1-adrenoceptor blockers.…”
Section: Introduction Methodsmentioning
confidence: 99%
“…Normotensive volunteers Impairment in complex tasks requiring attention, discrimination and accuracy has been described in normal volunteers [7,[28][29][30][31][32][33]. The degree of impairment seems to depend upon:…”
Section: -Adrenoceptor Blocking Agentsmentioning
confidence: 99%