Central Diabetes Insipidus Complicating West Nile Encephalitis

Sherman-Weber, Sofia; Axelrod, Peter

doi:10.1086/382702

Cited by 6 publications

(4 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…192 WNV also triggered development of central diabetes insipidus in a case with a history of diabetes and hypertension. 193 Studies linking yellow fever virus and diabetes have not been conducted till date and merit investigation. An overall trend of innate and adaptive immune diseases which are more-or-less similar in nature across the different types of viral infections have been highlighted in the figure shown below (Figure 2).…”

Section: The Interplay Of Immune Responses Against Other Prominent Fl...mentioning

confidence: 99%

“…There exists one case study where a patient infected with neuroinvasive WNV showed presence of DKA 192 . WNV also triggered development of central diabetes insipidus in a case with a history of diabetes and hypertension 193 . Studies linking yellow fever virus and diabetes have not been conducted till date and merit investigation.…”

Section: The Interplay Of Immune Responses Against Other Prominent Fl...mentioning

confidence: 99%

See 1 more Smart Citation

Viral infection and host immune response in diabetes

Joshi,

Das,

Verma

et al. 2023

IUBMB Life

View full text Add to dashboard Cite

Diabetes, a chronic metabolic disorder disrupting blood sugar regulation, has emerged as a prominent silent pandemic. Uncontrolled diabetes predisposes an individual to develop fatal complications like cardiovascular disorders, kidney damage, and neuropathies and aggravates the severity of treatable infections. Escalating cases of Type 1 and Type 2 diabetes correlate with a global upswing in diabetes‐linked mortality. As a growing global concern with limited preventive interventions, diabetes necessitates extensive research to mitigate its healthcare burden and assist ailing patients. An altered immune system exacerbated by chronic hyperinflammation heightens the susceptibility of diabetic individuals to microbial infections, including notable viruses like SARS‐CoV‐2, dengue, and influenza. Given such a scenario, we scrutinized the literature and compiled molecular pathways and signaling cascades related to immune compartments in diabetics that escalate the severity associated with the above‐mentioned viral infections in them as compared to healthy individuals. The pathogenesis of these viral infections that trigger diabetes compromises both innate and adaptive immune functions and pre‐existing diabetes also leads to heightened disease severity. Lastly, this review succinctly outlines available treatments for diabetics, which may hold promise as preventive or supportive measures to effectively combat these viral infections in the former.

show abstract

Section: The Interplay Of Immune Responses Against Other Prominent Fl...mentioning

confidence: 99%

Section: The Interplay Of Immune Responses Against Other Prominent Fl...mentioning

confidence: 99%

Viral infection and host immune response in diabetes

Joshi,

Das,

Verma

et al. 2023

IUBMB Life

View full text Add to dashboard Cite

show abstract

“…One case of stiff-person syndrome, a rare autoimmune disorder associated with antibodies against glutamic acid decarboxylase, has been reported after WNV infection (Hassin-Baer et al, 2004). One person with central diabetes insipidus complicating WNV encephalitis has been reported (Sherman- Weber and Axelrod, 2004). …”

Section: Miscellaneous Manifestationsmentioning

confidence: 99%

New and Evolving Infections of the 21st Century

Fong¹,

Alibek²

2007

View full text Add to dashboard Cite

“…In addition, less common presentations of WNV infection have included optic neuritis and chorioretinitis, as well as complications of vitritis, retinal artery occlusion, and intraretinal hemorrhages [18,19]. Other neurologic complications of WNV encephalitis have included diabetes insipidus [20].…”

Section: Clinical Presentationmentioning

confidence: 99%

West nile virus encephalitis

Dean

Palermo²

2005

Curr Infect Dis Rep

View full text Add to dashboard Cite

West Nile virus (WNV) is a small RNA virus. It was first isolated in the blood of a febrile woman in the West Nile district of Uganda in 1937. Although WNV has caused human disease in Africa and Europe since its identification, the first documented human infections occurred in the United States in 1999. Wild birds are the reservoir for WNV, and most transmission to humans occurs after the bite of an infected mosquito. In humans, 80% of infections are asymptomatic and nearly 20% cause a mild self-limiting illness called WNV fever. Less than 1% will develop central nervous system (CNS) infection, which manifests as meningitis, encephalitis, or acute flaccid paralysis. The case fatality rate for CNS infection is approximately 15%. Human vaccine is not available. Personal mosquito protection remains the best prevention, and treatment is supportive.

show abstract

Central Diabetes Insipidus Complicating West Nile Encephalitis

Cited by 6 publications

References 5 publications

Viral infection and host immune response in diabetes

Viral infection and host immune response in diabetes

New and Evolving Infections of the 21st Century

West nile virus encephalitis

Contact Info

Product

Resources

About