Central Giant Cell Granuloma of the Jaws: A Clinical Study of 17 Cases and a Review of the Literature

Triantafillidou, Katherine; Venetis, Grigoris; Karakinaris, G.; Iordanidis, Fotis

doi:10.1177/000348941112000305

Cited by 36 publications

(23 citation statements)

References 50 publications

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“…2 The use of calcitonin has been suggested as a supplementary treatment for aggressive CGCGs. 17 The present research showed a significant reduction in the frequency…”

Section: Discussionsupporting

confidence: 51%

Can calcitonin nasal spray reduce the risk of recurrence of central giant cell granuloma of the jaws? A double-blind clinical trial

Fardisi

Zamiri

Amanpour

et al. 2016

International Journal of Oral and Maxillofacial Surgery

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“…2 The use of calcitonin has been suggested as a supplementary treatment for aggressive CGCGs. 17 The present research showed a significant reduction in the frequency…”

Section: Discussionsupporting

confidence: 51%

Can calcitonin nasal spray reduce the risk of recurrence of central giant cell granuloma of the jaws? A double-blind clinical trial

Fardisi

Zamiri

Amanpour

et al. 2016

International Journal of Oral and Maxillofacial Surgery

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“…2 Microscopic examination reveals extravasated erythrocytes, an extensive amount of hemosiderin, and clusters of multinucleated giant cells within a scaffold of cellular spindle cells. 2 Positive histological staining includes iron, CD68, and CD163.…”

Section: Discussionmentioning

confidence: 99%

“…The differential diagnosis should consist of giant cell tumor, brown tumor, and aneurysmal bone cysts. 2 GCG is currently considered a benign non-neoplastic lesion. To date, there are no malignant transformations nor metastases reported.…”

Section: Discussionmentioning

confidence: 99%

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Giant Cell Granuloma of the Temporal Bone in a Mixed Martial Arts Fighter

et al. 2012

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Background and Importance Giant cell granuloma (GCG) is a rare, benign, non-neoplastic lesion of the head and neck. More common in the jaw bones, there have been few reports of the lesion arising in the temporal bone. Initially referred to as a “giant cell reparative granuloma,” due to the previously accepted notion of its nature in attempting to repair areas of injury, the term “giant cell granuloma” is now more frequently used as this lesion has been found in patients without a history of trauma. In addition, several cases with a destructive nature, in contrast to a reparative one, have been observed.Clinical Presentation We report a case of GCG presenting as a head and neck tumor with dural attachments and extension into the middle cranial fossa in a mixed martial arts fighter.Conclusion Giant cell granulomas are typically treated surgically and have a good prognosis; however, care must be taken when they present in unusual locations. This case supports the theory of trauma and inflammation as risk factors for GCG.

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“…Females are more frequently affected than males with a sex ratio of 2 : 1 and more than 70% of lesions affect mandible while very few cases have been reported in respect to maxilla. Clinically these lesions cause facial swelling, asymmetry, and expansion of cortical plates and radiologically resorption of roots of teeth with cortical perforation is well appreciated [ 3 ]. Patients who present with a central giant cell lesion in the maxilla or mandible should be screened for hyperparathyroidism (HPT) to differentiate the lesion as a brown tumour.…”

Section: Introductionmentioning

confidence: 99%

Central Giant Cell Granuloma of Posterior Maxilla: First Expression of Primary Hyperparathyroidism

Gulati

Bansal

Dubey

et al. 2015

Case Reports in Endocrinology

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A case of 19-year-old male patient reported with the chief complaint of slowly growing diffuse painless swelling over the right part of the face from last 6 months. Intraoral examination revealed a swelling on right side of palate in relation to molar region with buccal cortical plate expansion. Radiographic examination (orthopantograph and 3DCT) showed large multilocular radiolucency in right maxilla with generalized loss of lamina dura. Incisional biopsy was done and specimen was sent for histopathological examination which showed multinucleated giant cells containing 15–30 nuclei. Based on clinical, radiological, and histopathological findings provisional diagnosis of central giant cell granuloma was made. Blood tests after histopathology demonstrated elevated serum calcium level and alkaline phosphatase level. Immunoassay of parathyroid hormone (PTH) level was found to be highly elevated. Radiographic examination of long bones like humerus and femur, mandible, and skull was also done which showed osteoclastic lesions. Considering the clinical, radiographic, histopathological, and blood investigation findings, final diagnosis of brown tumour of maxilla was made. The patient underwent partial parathyroidectomy under general anaesthesia to control primary hyperparathyroidism. Surgical removal of the bony lesion was done by curettage. The patient has been followed up for 1 year with no postoperative complications and the lesion healed uneventfully.

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Central Giant Cell Granuloma of the Jaws: A Clinical Study of 17 Cases and a Review of the Literature

Abstract: Surgery has usually been considered to be the best method of treatment for CGCG. Most authors have proposed conservative surgical procedures (excision via curettage), especially for young patients. For aggressive lesions, supplementary treatment with calcitonin would provide good results.

Cited by 36 publications

References 50 publications

Can calcitonin nasal spray reduce the risk of recurrence of central giant cell granuloma of the jaws? A double-blind clinical trial

Can calcitonin nasal spray reduce the risk of recurrence of central giant cell granuloma of the jaws? A double-blind clinical trial

Giant Cell Granuloma of the Temporal Bone in a Mixed Martial Arts Fighter

Central Giant Cell Granuloma of Posterior Maxilla: First Expression of Primary Hyperparathyroidism

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