1990
DOI: 10.1007/bf00166960
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Central, naloxone-reversible antinociception by diclofenac in the rat

Abstract: The antinociceptive effect of subcutaneously (s.c.), intracerebroventricularly (i.c.v.) or intrathecally (i.t.) administered diclofenac was studied in a series of experiments employing the tail-flick (0.01-10.0 mg/kg body weight i.p., 1-50 micrograms i.c.v., 1-10 micrograms i.t.) and hot-plate (0.01-50 mg/kg body weight i.p., 1-50 micrograms i.c.v., 1-10 micrograms i.t.) models representing somatosensory stimuli and the writhing test (0.001 mg-10 mg s.c., 0.1-200 micrograms i.c.v., 0.1-100 micrograms i.t.) and… Show more

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Cited by 72 publications
(27 citation statements)
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“…Naloxone, a non-selective opioid antagonist, reversed the antinociceptive of the decoction in both phases of the formalin test. This finding clearly suggests that activation of opioid receptors and/or an increment of endogenous opioids, either centrally or peripherally, might be involved in the antinociceptive effect of N. latifolia decoction (Björkman et al, 1990).…”
Section: Germain Sotoing Taïwe Et Almentioning
confidence: 79%
“…Naloxone, a non-selective opioid antagonist, reversed the antinociceptive of the decoction in both phases of the formalin test. This finding clearly suggests that activation of opioid receptors and/or an increment of endogenous opioids, either centrally or peripherally, might be involved in the antinociceptive effect of N. latifolia decoction (Björkman et al, 1990).…”
Section: Germain Sotoing Taïwe Et Almentioning
confidence: 79%
“…Among several aspects described for central actions of NSAIDs, involvement of the opiate system was suggested by antagonism of analgesic effects by naloxone and other opioid antagonists and by changes in levels of endogenous opioids [14][15][16][18][19][20][21]. Effects on opioid receptors, which together with opioid ligands are main components of the opiate system, were not previously studied.…”
Section: Discussionmentioning
confidence: 99%
“…To explain central effects of NSAIDs, several hypotheses have been tested, including interactions with the serotoninergic system and inhibition of prostaglandin synthesis in the nervous system [8,11,[15][16][17]. In some cases central effects were found to be inhibited by naloxone [15,[18][19][20], suggesting involvement of the opiate system. Other studies provide direct evidence for involvement of the opioid system by modulation of secretion of endogenous ligands such as ß-endorphin and enkephalins [14,16,21].…”
Section: Introductionmentioning
confidence: 99%
“…Their opioid sparing effect and availability in parenteral forms make them ideal for day-only and short-stay admissions for elective surgery [9][10][11][12]. The rational for their use is that they produce inhibition of peripheral hyperalgesia mediated by their anti-inflammatory properties 13, possibly supplemented by centrally mediated actions that attenuate central sensitization [13][14][15][16][17]. Available drugs in Bangladeshi market are Aceclofenac, Dexibuprofen, Dexketoprofen, Diclofenac diethyl ammonium salt, Diclofenac free acid, Diclofenac potassium, Diclofenac sodium, Diclofenac Sodium+Misoprostol, Etodolac, Naproxen, etc.…”
Section: Introductionmentioning
confidence: 99%