Central odontogenic granular cell tumor: Immunohistochemical study of two cases

Sousa, Suzana Orsini Machado de; Araújo, Ney Soares de; Melhado, Ronaldo Maia; Araújo, Vera Cavalcanti de

doi:10.1016/s0278-2391(98)90821-7

Cited by 22 publications

(16 citation statements)

References 19 publications

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“…Our results confirm the data reported by the others for the immune‐phenotypic characterisation of the granular cells, which were positive for CD68 and vimentin, 8,10,13,15,33 and negative for NSE and S‐100 8,11,13–15 . The immunoreactivity for CD68 and vimentin supports the histiocytic origin of the granular cells.…”

Section: Discussionsupporting

confidence: 91%

“…Although radiographical findings are non‐pathognomonic, CGCOT often presents as a well‐demarcated unilocular radiolucency 4,12–14 . In a few cases, lesions appeared multilocular, radiopaque or mixed 10,15 . Table 1 briefly summarises information on the age and sex of the patients, tumour localisations and radiological findings.…”

Section: Introductionmentioning

confidence: 99%

“…4,[12][13][14] In a few cases, lesions appeared multilocular, radiopaque or mixed. 10,15 This neoplasm has generally a benign behaviour. However, a case of recurrence was reported by Brannon et al 13 and a malignant variant of this tumour was described by Piattelli et al 33 To date, the enucleation of the lesion, curettage and, if necessary, the additional extraction of teeth seems to be an adequate treatment for CGCOT.…”

Section: Introductionmentioning

confidence: 99%

“…However, a case of recurrence was reported by Brannon et al 13 and a malignant variant of this tumour was described by Piattelli et al 33 To date, the enucleation of the lesion, curettage and, if necessary, the additional extraction of teeth seems to be an adequate treatment for CGCOT. 1,15 The purpose of this case report is to describe an unusual case of CGCOT and provide knowledge about this rare tumour.…”

Section: Introductionmentioning

confidence: 99%

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Central granular cell odontogenic tumour associated with sepsis, osteonecrosis and osteomyelitis

et al. 2021

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This report provides information about a rare neoplasm called central granular cell odontogenic tumour and emphasises the importance of sending samples collected during oral surgery for histopathologic examination. Indeed, this report confirms that the final diagnosis in Oral Pathology is the result of a multidisciplinary approach, based on intraoral examination, radiographic images and pathological findings.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Central granular cell odontogenic tumour associated with sepsis, osteonecrosis and osteomyelitis

et al. 2021

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“…In addition, some odontogenic tumors may exhibit varying amounts of granular cell change, e.g. ameloblastoma [22], central odontogenic granular cell tumor [23][24][25], and odontogenic fibroma [26][27][28]. Malignant neoplasms that may exhibit granular cells are malignant granular cell tumors [29] and granular cell variants of angiosarcoma, leiomyosarcoma, and melanoma [4].…”

Section: Discussionmentioning

confidence: 99%

S-100 Negative Granular Cell Tumor of the Oral Cavity

Solomon

Velez

2015

Head and Neck Pathol

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Classic granular cell tumor is a mesenchymal neoplasm that commonly occurs on the skin, but is not infrequently found in the oral cavity, primarily on the dorsal tongue. Diagnosis is usually straightforward with hematoxylin and eosin stained slides. Immunohistochemical studies on classic granular cell tumor shows positive immunostaining for S-100 and vimentin, while CD68 is variably positive. We report a case of otherwise unremarkable oral granular cell tumor that was immunohistochemically negative for S-100, and positive for vimentin and CD68, and discuss the differential diagnosis. The results of the immunohistochemical studies in our case are compared with those of classic S-100 positive oral granular cell tumors, as well as cutaneous and oral S-100 negative granular cell tumors. Classic S-100 positive granular cell tumors and S-100 negative granular cell tumors of the oral cavity can only be distinguished by immunohistochemical studies; however, the necessity of this distinction is unclear, as both are benign lesions in which recurrence is unlikely.

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