2015
DOI: 10.2337/db15-0153
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Centroacinar Cells Are Progenitors That Contribute to Endocrine Pancreas Regeneration

Abstract: Diabetes is associated with a paucity of insulin-producing β-cells. With the goal of finding therapeutic routes to treat diabetes, we aim to find molecular and cellular mechanisms involved in β-cell neogenesis and regeneration. To facilitate discovery of such mechanisms, we use a vertebrate organism where pancreatic cells readily regenerate. The larval zebrafish pancreas contains Notch-responsive progenitors that during development give rise to adult ductal, endocrine, and centroacinar cells (CACs). Adult CACs… Show more

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Cited by 78 publications
(118 citation statements)
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“…However, the regenerative response of the mammalian pancreas can vary depending on the injury model (Criscimanna et al, 2011; Kopp et al, 2011; Lee et al, 2006; Li et al, 2010; Nagasao et al, 2005; Xu et al, 2008), making uncovering mechanisms of regeneration in those animals difficult. On the other hand, as we will discuss here, the zebrafish pancreas displays a remarkable capacity for regeneration (Delaspre et al, 2015; Ghaye et al, 2015; Moss et al, 2009). A detailed understanding of how the fish pancreas regenerates is thus the critical first step towards achieving endogenous β-cell replacement therapy in humans.…”
Section: Introductionmentioning
confidence: 90%
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“…However, the regenerative response of the mammalian pancreas can vary depending on the injury model (Criscimanna et al, 2011; Kopp et al, 2011; Lee et al, 2006; Li et al, 2010; Nagasao et al, 2005; Xu et al, 2008), making uncovering mechanisms of regeneration in those animals difficult. On the other hand, as we will discuss here, the zebrafish pancreas displays a remarkable capacity for regeneration (Delaspre et al, 2015; Ghaye et al, 2015; Moss et al, 2009). A detailed understanding of how the fish pancreas regenerates is thus the critical first step towards achieving endogenous β-cell replacement therapy in humans.…”
Section: Introductionmentioning
confidence: 90%
“…In both zebrafish and mammals, transmission electron microscopy studies of CAC ultrastructure have detailed a unique ruffled nuclear morphology and the close association of CACs with both acinar and other ductal cells via tight junctions (Parsons et al, 2009; Pour, 1994) (Figure 3E). Interestingly, contrasting other duct cells that contribute to cuboidal and columnar epithelium, in all vertebrates examined CACs have long cytoplasmic extensions (Figure 1C and 2D) that extend along the duct to contact neighboring CACs and into the parenchyma to touch other neighboring cells, including islets (Delaspre et al, 2015; Leeson and Leeson, 1986; Pour, 1994). Notably, zebrafish CACs seem to have much longer extensions than mammalian CACs.…”
Section: Centroacinar Cells Are Specialized Ductal Cellsmentioning
confidence: 99%
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