Centrosome inheritance in starfish zygotes: Selective loss of the maternal centrosome after fertilization

Sluder, Greenfield; Miller, Frederick J.; Lewis, K.; Davison, Edwin; Rieder, Conly L.

doi:10.1016/s0012-1606(89)80027-2

Cited by 102 publications

(65 citation statements)

References 41 publications

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“…A different regulatory logic is encountered during spermatogenesis in insects (reviewed by Callaini et al, 1999) and oogenesis in species of the starfish genus Pisaster (Sluder et al, 1989a), where centrosome duplication occurs solely prior to meiosis I. In the absence of duplication prior to meiosis II, the centriole pair disconnects and each daughter cell inherits a single centriole.…”

Section: Building a Daughter Centriolementioning

confidence: 99%

The arithmetic of centrosome biogenesis

Delattre¹,

Gönczy²

2004

Journal of Cell Science

145

110

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How do cells regulate centrosome number? A canonical duplication cycle generates two centrosomes from one in most proliferating cells. Centrioles are key to this process, and molecules such as centrins, SAS-4 and ZYG-1 govern daughter centriole formation. Cdk2 activity probably couples centrosome duplication with the S phase, and a licensing mechanism appears to limit centrosome duplication to once per cell cycle. However, such mechanisms must be altered in some cells – for example, spermatocytes – in which centrosome duplication and DNA replication are uncoupled. There are also alternative pathways of centrosome biogenesis. For example, one centrosome is reconstituted from two gametes at fertilization; in this case, the most common strategy involves differential contributions of centrioles and pericentriolar material (PCM) from each gamete. Furthermore, centrioles can sometimes form de novo from no apparent template. This occurs, for instance, in the early mouse embryo and in parthenogenetic species and might rely on a pre-existing seed that resides within PCM but is not visible by ultrastructural analysis.

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Section: Building a Daughter Centriolementioning

confidence: 99%

The arithmetic of centrosome biogenesis

Delattre¹,

Gönczy²

2004

Journal of Cell Science

145

110

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“…In Drosophila and C. elegans for instance, the centrioles are lost before the first meiotic division so that the poles of the female meiotic spindles are acentriolar (Albertson and Thomson, 1993;Megraw and Kaufman, 2000). In contrast, in both starfish (Sluder et al, 1989a) and surf clams (Wu and Palazzo, 1999), centrioles are present on the female meiotic spindles but these maternal centrioles do not participate in the zygotic divisions. At present, the mechanisms that underlie the uniparental inheritance of centrioles in any organism have not been characterized at a molecular level.…”

Section: Sexual Reproduction and The Maintenance Of Centriole Numbermentioning

confidence: 99%

“…That is, within a given species, the zygotic centrioles are either of maternal or paternal origin. In most of the organisms studied so far, the zygotic centrioles are donated by the sperm and are thus strictly of paternal origin (Sluder et al, 1989a;Albertson and Thomson, 1993;Schatten, 1994).…”

Section: Sexual Reproduction and The Maintenance Of Centriole Numbermentioning

confidence: 99%

“…Thus, C-Nap1 might form part of a tether between mother and daughter and Nek2 might regulate this connection through phosphorylation of C-Nap1. Because separation of mother and daughter does not require that new centrioles first be synthesized (Sluder and Rieder, 1985;Sluder et al, 1989a), mutations that block centriole assembly can be analysed for effects on downstream events. In zyg-1 mutants, centrioles appear perfectly capable of migrating apart and thus, ZYG-1 does not appear to function at this step in the cycle.…”

Section: Molecular and Genetic Analysis Of Centriole Replication In Cmentioning

confidence: 99%

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The ZYG-1 kinase, a mitotic and meiotic regulator of centriole replication

O’Connell

2002

Oncogene

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“…1. According to Sluder et al (Sluder et al, 1989) and Kato et al (Kato et al, 1990), each pole of a meiosis-I spindle in starfish oocytes has a pair of centrioles (Fig. 1B), but only one centriole is found in each pole of the meiosis-II spindle (Fig.…”

Section: Introductionmentioning

confidence: 99%

Centrosome destined to decay in starfish oocytes

Shirato

Tamura

Yoneda³

et al. 2006

Development

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In contrast to the somatic cell cycle, duplication of the centrioles does not occur in the second meiotic cycle. Previous studies have revealed that in starfish each of the two centrosomes in fully-grown immature oocytes consists of two centrioles with different destinies: one survives and retains its reproductive capacity, and the other is lost after completion of meiosis. In this study, we investigated whether this heterogeneity of the meiotic centrioles is already determined before the re-initiation of meiosis. We prepared a small fragment of immature oocyte containing the four centrioles and fused it electrically with a mature egg in order to transfer two sets of the premeiotic centrioles into the mature cytoplasm. Two asters were present in this conjugate, and in each of them only a single centriole was detected by electron microscopy. In the first mitosis of the conjugate artificially activated without sperm, two division poles formed, each of which doubled in each subsequent round of mitosis. These results indicate that only two of the four premeiotic centrioles survived in the mature cytoplasm and that they retained their reproductive capacity, which suggests that the heterogeneity of the maternal centrioles is determined well before re-initiation of meiosis,and that some factor in the mature cytoplasm is responsible for suppressing the reproductive capacity of the centrioles destined to decay.

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Centrosome inheritance in starfish zygotes: Selective loss of the maternal centrosome after fertilization

Cited by 102 publications

References 41 publications

The arithmetic of centrosome biogenesis

The arithmetic of centrosome biogenesis

The ZYG-1 kinase, a mitotic and meiotic regulator of centriole replication

Centrosome destined to decay in starfish oocytes

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