Cerebellar liponeurocytoma: A case report and review of the literature

Abstract

Abstract. Cerebellar liponeurocytoma is rare, and the clinical characteristics and treatment strategy remain unclear. In the present study, a case of cerebellar liponeurocytoma was retrospectively reported and a literature review was performed. A 45-year-old female presented due to occipital headaches, exhibiting a hoarse voice and a broad-based gait. Pre-operative magnetic resonance images revealed a lesion occupying the right hemisphere of the cerebellum and the inferior vermis, compressing the medulla oblongata from the right side, and extending through the foramen magnum to the C2 level. A total resection was performed, and pathological analysis of the lesion showed positivity for synaptophysin, S-100 and neuronal nuclear antigen, partial positivity for Olig-2, and negativity for glial fibrillary acidic protein and epithelial membrane antigen. In addition, the Ki-67 index was low (<5%). Thus, a diagnosis of cerebellar liponeurocytoma was determined. Total resection was successful and the patient was followed up closely. A review of the literature showed that cerebellar liponeurocytoma is mainly located in the cerebellum, with rare extra-cerebellar cases. Certain studies have suggested that the tumor may be located supratentorially and subtentorially, and should be renamed as solely liponeurocytoma. Total resection of the tumor contributes to an improved prognosis, while a subtotal resection and high Ki-67 index lead to recurrence. The tumor is similar to a tumor of low malignancy, with long-term recurrence. Radiation is recommended when there is residual tumor, recurrence or when the Ki-67 is high.

Cerebellar Liponeurocytoma: A Novel Report from Nigeria in a 6-Year-Old Girl, and Review of Literature

“…However, rather than exposing the patients to the risks and side-effects of radiotherapy, without any evidence to support its usefulness in preventing recurrence, we recommend reoperation on a recurrent tumor, which has only a slightly more aggressive histology than the primary presentation, with the option of using adjuvant radiotherapy at this time. 3 Further studies regarding the natural history of this lesion are warranted. 4…”

Clinical features and prognosis for intraventricular liponeurocytoma

“…This neoplasm develops predominantly in cerebellar hemisphere and vermis, occasionally in supratentorial lateral ventricle and the fourth ventricle. So far, approximately 47 cases of cerebellar, 11 cases of supratentorial intraventricular and 2 cases of fourth ventricular liponeurocytomas are on record in the English literature [ 5 - 11 ]. Comparing to the liponeurocytoma occurred in cerebellum, little is known about intraventricular liponeurocytoma due to the lower number of reported cases.…”

Cerebellar liponeurocytoma with atypical histological features – a rare example of a glioneuronal tumor

“…Thus, CLNC is different from medulloblastoma and more similar to neurocytoma but with a distinct genetic pathway due to the presence of TP53 mutations [14]. Moreover, Hirokazu et al [32] reported the absence of both chromosome 1p/19q loss and IDH1 mutation, which might be useful in differential diagnosis of oligodendroglioma [4]. Our tumor showed neither immunohistochemical features of p53 and IDH1 alterations nor SHH and β-catenin activation.…”

“…It was first described in 1978 by Bechtel et al [2], and nearly 50 cases under several synonyms have been reported since [11,26,32,33]. In the 2000 World Health Organization (WHO) classification of Tumors of the Central Nervous System it was categorized for the first time as a distinct entity within the neuronal and mixed neuronal-glial tumors section.…”