Cerebellar Mutism and Reversible Cytotoxic Edema in Influenza B–Associated Encephalopathy

Thabet, Farouq I.; Khalil, Suad; Naz, Fareeha; Dyme, I.Zachary

doi:10.1016/j.pediatrneurol.2013.06.014

Cited by 13 publications

(7 citation statements)

References 14 publications

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“…Overall, disease caused by FluB is indistinguishable from that of FluA [18], although complications can differ. Complications of FluB can include neurological and muscular manifestations [19,20], cardiologic complications [21][22][23] and secondary bacterial infections [22,24,25]. Paddock et al (2012) observed that secondary bacterial pneumonia was more frequently observed in adult fatal cases of FluB than pediatric fatal cases, and the reverse was observed for cardiac complications.…”

Section: Epidemiology and Clinical Presentation Of Flubmentioning

confidence: 99%

Knowns and Unknowns of Influenza B Viruses

et al. 2015

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Influenza B viruses (IBVs) circulate annually along with influenza A (IAV) strains during seasonal epidemics. IBV can dominate influenza seasons and cause severe disease, particularly in children and adolescents. Research has revealed interesting aspects of IBV and highlighted the importance of these viruses in clinical settings. Yet, many important questions remain unanswered. In this review, the clinical relevance of IBV is emphasized, unique features in epidemiology, host range and virology are highlighted and gaps in knowledge pinpointed. Multiple aspects of IBV epidemiology, evolution, virology and immunology are discussed. Future research into IBV is needed to understand how we can prevent severe disease in high-risk groups, especially children and elderly.

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Section: Epidemiology and Clinical Presentation Of Flubmentioning

confidence: 99%

Knowns and Unknowns of Influenza B Viruses

et al. 2015

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“…During 2003During -2008, the mortality attributable to IBV was estimated to be higher than that to H3N2 or H1N1 in China [3]. Furthermore, influenza B virus caused more complications, including neurological, muscular manifestations [4,5] and cardiologic complications [6,7].…”

Section: Introductionmentioning

confidence: 99%

Lianhua‐Qingwen Displays Antiviral and Anti‐Inflammatory Activity and Synergistic Effects with Oseltamivir against Influenza B Virus Infection in the Mouse Model

Yang

Wang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Influenza B virus (IBV) is one of the main pathogens of the annual influenza epidemic, and the disease burden is significant, especially among children and young teenagers. In this study, the antiviral and anti-inflammatory effects of a traditional Chinese medicine prescription, the Lianhua-Qingwen capsule, were evaluated. Our results showed that Lianhua-Qingwen capsule can inhibit both Victoria and Yamagata lineages, and the 50% inhibitive concentrations ranged from 0.228 ± 0.150 to 0.754 ± 0.161 mg/mL. The time course results demonstrated that IBV yields were reduced with treatment at 0–4 h after infection, and the mechanistic research verified that Lianhua-Qingwen capsule has hemagglutination inhibition activity against B/Guangzhou/0215/2012 but not A/California/04/2009. In addition to antiviral activity, Lianhua-Qingwen capsule can also inhibit excessive expression of RANTES, IL-6, IL-8, IP-10, TNF-α, MCP-1, MIP-1β, and IFN-λ at the mRNA level and prevent a severe inflammatory response. The in vivo results confirmed that orally administered Lianhua-Qingwen capsule (100–400 mg/kg/day) does not reduce IBV-induced lung viral load and mortality in mice. However, the pathological change in lungs was alleviated, and there were fewer inflammatory cells in the lungs of Lianhua-Qingwen capsule treated mice than those in controls. Further research confirmed that the combination treatment of 200 mg/kg/day of Lianhua-Qingwen capsule with 2 mg/kg/day of oseltamivir significantly reduced IBV infection over the individual administration of either alone in vivo. Our findings prove that Lianhua-Qingwen capsule could be used as an assistant medicine to enhance the effect of oseltamivir against influenza B virus infection.

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“…stem, and cerebellum. Patients present with acute necrotizing encephalopathy [(84)(85)(86)(87)(88)]. Reversible splenial lesions have been reported [(87,89)].…”

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confidence: 99%

MR imaging of adult acute infectious encephalitis

Bertrand

Leclercq

Martinez-Almoyna

et al. 2017

Médecine et Maladies Infectieuses

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Brain MRI plays a crucial role in the diagnosis of acute encephalitis. It detects brain signal changes that reinforce the clinical suspicion of encephalitis, especially when the causative agent is not identified by lumbar puncture; it can suggest a particular pathogen based on the pattern of brain abnormalities and it rules out important differential diagnosis (vascular, tumoral or inflammatory causes).

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Cerebellar Mutism and Reversible Cytotoxic Edema in Influenza B–Associated Encephalopathy

Cited by 13 publications

References 14 publications

Knowns and Unknowns of Influenza B Viruses

Knowns and Unknowns of Influenza B Viruses

Lianhua‐Qingwen Displays Antiviral and Anti‐Inflammatory Activity and Synergistic Effects with Oseltamivir against Influenza B Virus Infection in the Mouse Model

MR imaging of adult acute infectious encephalitis

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