Cerebral Hemorrhage Due to Hyperleukocytosis

Shiber, Joseph

doi:10.1016/j.jemermed.2008.11.018

Cited by 17 publications

(23 citation statements)

References 24 publications

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“…the HL60 cells are less deformable than the K562 cells. It was reported that the risk of leukostasis of chronic leukaemia patients is smaller those suffering acute leukaemia 9,27 , and so the elastic moduli measured here for normal leukaemia cells agree with this finding, if leukostasis is linked to increased stiffness. The elastic moduli of normal HL60 cells was measured as 213.1±21.4 Pa, which is significantly lower than the 855±670 Pa measured with AFM nanoindentation previously 9 , but the results reported previously have large scattering presumably because a larger sample size of 60 was used, and the elastic moduli measured here are still in the range of the previously report ones, albeit with much less scattering.…”

Section: Resultssupporting

confidence: 88%

The Biomechanics of Drug-Treated Leukemia Cells Investigated Using Optical Tweezers

2012

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Leukemia is a very common cancer worldwide, and different drugs have been applied to treat the disease. However, the influence of the drugs on the biomechanical properties of leukemia cells, which are related to the risk of leukostasis, is still unknown. Moreover, accurate measurement of biomechanical properties of leukemia cells is still a challenging task because of their non-adherent nature and high sensitivity to the surrounding physiological conditions. In this study, a protocol to measure the biomechanical properties of leukemia cells by performing indentation tests using optical tweezers is proposed. The biomechanical properties of normal leukemia cells and cells treated with various cancer drugs, including phorbol 12-myristate 13-acetate (PMA), all-trans retinoic acid (ATRa), Cytoxan (CTX), and Dexamethasone (DEX), were measured. The adhesion between the cells and certain proteins existing in the extracellular matrix, i.e., fibronetin and collagen I, was also characterized with the help of a static adhesion assay. It was found that after treatment by ATRa, CTX, and DEX, the cells became softer, and the adhesion between the cells and the proteins became weaker. PMA treatment caused no change in the stiffness of the HL60 cells, but increased the stiffness of the K562 cells, and increased the cell–protein adhesion of both K562 cells and HL60 cells.

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Section: Resultssupporting

confidence: 88%

The Biomechanics of Drug-Treated Leukemia Cells Investigated Using Optical Tweezers

2012

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“…Following emergency treatment and combination chemotherapy, the male achieved complete remission (1). In an additional report (5), a 19-year-old male was diagnosed with ALL (WBC count of 121.0×10 9 /l). Brain CT showed multiple areas of parenchymal haemorrhage with intraventricular hemorrhage and subdural hematoma along the posterior falx.…”

Section: Discussionmentioning

confidence: 97%

Hyperleukocytosis: A report of five cases and review of the literature

Gong

Guo

et al. 2014

Oncology Letters

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Hyperleukocytosis (white blood cell count, >100×109/l), an uncommon presentation of leukemia, is associated with an increased risk of early mortality. It may present with a variety of symptoms secondary to leukostasis, a syndrome caused by the sludging of circulating leukemic blasts in the microvasculature. Adequate measures for managing this medical emergency include hydration, cytoreduction, prevention of tumor lysis and, rarely, leukapheresis in cases complicated by leukostasis and hyperviscosity syndrome. The present study reports a case series of five patients with hyperleukocytic leukemia. In addition, a review of the literature with regard to the incidence, pathophysiology, clinical manifestations and management of this laboratory abnormality is included. This study demonstrated that the central nervous system and lungs are the most common sites for leukostasis, and that emergency cases require aggressive treatment.

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“…However, it is extremely rare to encounter ICH as the initial presentation of previously undiagnosed acute leukemia. To our knowledge, only 4 cases have been reported [3][4][5][6]. We present a case of multiple ICHs prior to the diagnosis of acute leukemia.…”

Section: Introductionmentioning

confidence: 91%