Cerebral infarction in the Mongolian gerbil exacerbated by phenoxybenzamine treatment.

McGraw, C. P.; Pashayan, Annette G.; Wendel, O.T.

doi:10.1161/01.str.7.5.485

Cited by 25 publications

(12 citation statements)

References 30 publications

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“…Our previous autoradiographic assessment with 14 Cantipyrine" revealed a marked rCBF increase in the ischemic hemisphere of gerbils that had been exposed to 1 h ischemia when the systemic blood pressure was elevated to 130-150 mm Hg after blood flow restoration. In the same study, diffuse oligemia was noted in This led to the consideration that a slight increase in systemic arterial blood pressure may effect an increase in the perfusion pressure in the post-ischemic brain, because cerebrovascular autoregulation had been disturbed by the ischemic insult, and that this increased perfusion pressure may result in BBB change.…”

Section: Discussionmentioning

confidence: 95%

Effect of hypertension on blood-brain barrier. Change after restoration of blood flow in post-ischemic gerbil brains. An electronmicroscopic study.

Ito¹,

Ohno²,

Yamaguchi³

et al. 1980

Stroke

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SUMMARYThe effect of induced hypertension on the blood-brain barrier (BBB) change in Mongolian gerbils exposed to various periods of ischemia was studied. EVANS blue dye was used to determine the BBB change In animals subjected to different levels of hypertension after 3 h ischemia. Horseradish peroxidase (HRP) was used in electronmicroscopic studies of animals subjected to 30 min, 1,3 or 6 h ischemia and subsequently exposed for 30 min to varying periods and sequences of nonno-and hypertension. Furthermore, HRP-labeled vesicle counts were performed in animals from the 30-min ischemia group.Our findings revealed that hypertension, after blood flow restoration following ischemia, induces and/or accelerates BBB damage by enhancing endotheiial vesicular and/or tubuio-channel transport.Stroke, Vol 11, No 6, 1980WHETHER AN INCREASE of blood pressure has a beneficial effect on the ischemic brain is still a matter of debate in clinical studies.1 -* The ischemic brain has been reported to be highly-resistant to blood-brain barrier (BBB) M change which induces vasogenic edema.8 However, it has been reported that a BBB change can occur after restoration of the blood flow to the ischemic brain. "10 The present study was undertaken to determine how a slight change in blood pressure after blood flow restoration might affect the BBB after ischemia, and to elucidate the ultrastructural mechanisms of this BBB change.The results of this line of inquiry may be of clinical importance in managing patients after the surgical restoration of blood flow to ischemic brain, and in the treatment of cerebral apoplexy without angiographic evidence of vascular obstruction 11 '1J and/or with evidence of rich collateral circulation. Materials and MethodsIschemia was produced in adult Mongolian gerbils of either sex under light ether anesthesia by clipping the left carotid artery with Scovill's aneurysmal clip. Polyethylene tubing (PE 10, Clay-Adams, USA) was inserted through the femoral artery to the abdominal aorta of all ischemia-sensitive animals, selected according to previously described criteria."• M Systemic arterial blood pressure was monitored continuously on a Statham transducer. Under pentobarbital anesthesia (1 mg/100 g body weight, i.p.), 0.1-0.5 mg/kg body weight metaraminol bitartrate was repeatedly injected i.v. to maintain the mean arterial blood pressure (MABP) at different levels of elevation. In each animal, MABP was measured at 5 min intervals after blood flow restoration. BBB Change after 3 h Ischemia Demonstrated by Evans Blue PermeabilityAll animals received an i.v. injection of 0.1 ml/100 g body weight of 2% Evans blue dye immediately before clip release. They were sacrificed 5 min to 5 h thereafter by 10% buffered paraformaldehyde perfusion. Abnormal permeability of the BBB to the dye was assessed by visual inspection of coronal blocks of the perfused brains.The animals were divided into 4 groups according to the different levels of MABP (table). Animals were considered to be positive for BBB change when a blue spot ...

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Section: Discussionmentioning

confidence: 95%

Effect of hypertension on blood-brain barrier. Change after restoration of blood flow in post-ischemic gerbil brains. An electronmicroscopic study.

Ito¹,

Ohno²,

Yamaguchi³

et al. 1980

Stroke

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“…Neither HAL nor propranolol (PROP) reinstated deficits in the recovered animals. Other investigators have found that PBZ increases the incidence of stroke, worsens neurological symptoms, and causes high mortality in an experimental stroke model (McGraw, Pashyan, & Wendell, 1976). Additionally, a clinical study with ischemIc or infarcted patients reported that a combined treatment with PBZ and PROP worsened neurological deficits in some patients (J. S. Meyer et al, 1976).…”

Section: Discussionmentioning

confidence: 98%

The locus coeruleus and cerebral metabolism: Recovery of function after cortical injury

et al. 1985

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Cerebral metabolic effects of locus coeruleus (LC) lesion or drugs affecting LC were investigated after unilateral injury of sensorimotor cortex in rats. Sensoriomotor cortex ablation produced a widespread depression of cerebral 14C-2-deoxyglucose utilization which was reversed by amphetamine (AMP, 2 mg/kg) and worsened by haloperidol (HAL, 0.4 mg/kg). Lesion of LC alone did not affect cerebral oxidative metabolism, measured by a stain for the enzyme alphaglycerophosphate dehydrogenase (a-GPDH). Lesion of LC prior to undercut laceration of motor cortex shortened time to onset of a-GPDH cortical paling. Treatment with AMP (2 mg/kg) blocked cortical paling ofthe enzyme stain at 4 days postinjury, an effect prevented by concomitant HAL (0.3 or 0.6 mg/kg). Apomorphine (1 mg/kg) did not block cortical paling. These data parallel effects of these drugs on recovery of function. The results suggest that a metabolic "remote functional depression" (RFD) is alleviated by catecholamine activation after cortical injury, whereas onset of RFD is accelerated by LC lesions and exacerbated by catecholamine blockade.The locus coeruleus (LC) may have an important role in neuronal development and plasticity (Felton, Hallman,

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“…The assessment of neurological status of the animal was carried out in 3 stages: assessment of the dynamics of neurological disorders on a McGrow scale on day 1, 3, 7 and 14 [1,5]; on the first day - …”

Section: Methodsmentioning

confidence: 99%

“…4 Солгалова А.С. 5 Анциферов О.В. 6 МОДЕЛИРОВАНИЕ ТОТАЛЬНОЙ ИШЕМИИ ГОЛОВНОГО МОЗГА У КРЫС 1) аспирант кафедры фармакологии Медицинского института НИУ «БелГУ», 308015, Белгород, ул.…”

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Simulation of Total Brain Ischemia in Rats

Martynova¹,

Гуреев²,

Pokrovskiy³

et al. 2015

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Martynova O.V., Gureev V.V., Pokrovskiy M.V., Martynov M.A., Solgalova A.S., Anciferov O.V. Simulation of total brain ischemia in rats // Сетевой журнал «Научный результат». Серия «Медицина и фармация». -Т.1, №4(6), 2015. 69 Серия МЕДИЦИНА И ФАРМАЦИЯ MEDICINE AND PHARMACY Series SUMMARY. This paper deals with the study of the dependence of psycho neurological deficit in rats on the severity of brain damage, conducted on the four-vascular models of total cerebral ischemia. The obtained results demonstrate a tendency to deterioration of neuropsychiatric status of the animals with increasing severity of ischemic brain damage that allows suggesting the severity of ischemic brain damage and its correction by the degree of behavioral disorders. Keywords: total brain ischemia, neurologic deficiency, rats. Аннотация. Проведено исследование зависимости психоневрологического дефицита у крыс от степени тяжести повреждения головного мозга, на четырехсосудистой модели тотальной ишемии головного мозга. Результаты исследования доказывают тенденцию ухудшения психоневрологического статуса животных при увеличении тяжести ишемического повреждения головного мозга, что позволяет по степени нарушения поведенческих реакций судить о тяжести ишемического поражения головного мозга и его коррекции. Ключевые слова: тотальная ишемия головного мозга, неврологический дефицит, крысы.Martynova O.V., Gureev V.V., Pokrovskiy M.V., Martynov M.A., Solgalova A.S., Anciferov O.V. Simulation of total brain ischemia in rats // Сетевой журнал «Научный результат». Серия «Медицина и фармация». -Т

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Cerebral infarction in the Mongolian gerbil exacerbated by phenoxybenzamine treatment.

Cited by 25 publications

References 30 publications

Effect of hypertension on blood-brain barrier. Change after restoration of blood flow in post-ischemic gerbil brains. An electronmicroscopic study.

Effect of hypertension on blood-brain barrier. Change after restoration of blood flow in post-ischemic gerbil brains. An electronmicroscopic study.

The locus coeruleus and cerebral metabolism: Recovery of function after cortical injury

Simulation of Total Brain Ischemia in Rats

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