Cerebral MRI findings in very-low-birth-weight and small-for-gestational-age children at 15 years of age

Skranes, Jon; Martinussen, Marit; Smevik, Olaug; Myhr, Gunnar; Indredavik, Marit S.; Vik, Torstein; Brubakk, Ann‐Mari

doi:10.1007/s00247-005-1446-2

Cited by 62 publications

(51 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Because of the large contrast between brain tissue and CSF intensities in these regions, small decreases in volume that may not be apparent in the volumetric maps could result in an increase in tissue signal intensity attributed to partial volume effects. However, this finding remains inconclusive given that, although ventriculomegaly has been shown to be less prevalent in small for gestational age (SGA) adolescents compared to those born preterm,42 there is only limited evidence of a thinner mesencephalon in SGA preterm infants43 and IUGR appears to be related to a relatively larger brainstem and cerebellar volumes in infants born at term 44. Increases in callosal FA have been previously reported in growth‐restricted infants at 12 months 45…”

Section: Discussionmentioning

confidence: 99%

Multimodal image analysis of clinical influences on preterm brain development

Ball

Aljabar

Nongena

et al. 2017

Annals of Neurology

View full text Add to dashboard Cite

ObjectivePremature birth is associated with numerous complex abnormalities of white and gray matter and a high incidence of long‐term neurocognitive impairment. An integrated understanding of these abnormalities and their association with clinical events is lacking. The aim of this study was to identify specific patterns of abnormal cerebral development and their antenatal and postnatal antecedents.MethodsIn a prospective cohort of 449 infants (226 male), we performed a multivariate and data‐driven analysis combining multiple imaging modalities. Using canonical correlation analysis, we sought separable multimodal imaging markers associated with specific clinical and environmental factors and correlated to neurodevelopmental outcome at 2 years.ResultsWe found five independent patterns of neuroanatomical variation that related to clinical factors including age, prematurity, sex, intrauterine complications, and postnatal adversity. We also confirmed the association between imaging markers of neuroanatomical abnormality and poor cognitive and motor outcomes at 2 years.InterpretationThis data‐driven approach defined novel and clinically relevant imaging markers of cerebral maldevelopment, which offer new insights into the nature of preterm brain injury. Ann Neurol 2017;82:233–246

show abstract

Section: Discussionmentioning

confidence: 99%

Multimodal image analysis of clinical influences on preterm brain development

Ball

Aljabar

Nongena

et al. 2017

Annals of Neurology

View full text Add to dashboard Cite

show abstract

“…4,11 This heterogeneity in study design limits the number of quantitative studies with which to compare the present results. 8,11,27 Several qualitative studies 6,7,28 have used the evaluation of the size of the CC by an expert (radiologist) and have described a thinning of the CC in VLBW adolescents, however, without addressing the different subregions, or taking the overall head size into consideration. These results agree with a previous report from the current cohort 17 and also with the preadjusted results from the present study, reflecting difficulties both related to subjective assessment alone and to the justification of adjusting for total forebrain size.…”

Section: Discussionmentioning

confidence: 99%

Selectively Reduced Posterior Corpus Callosum Size in a Population-Based Sample of Young Adults Born with Low Birth Weight

Aukland

Westerhausen²,

Plessen³

et al. 2011

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

show abstract

“…All were born in Central Norway in 1987-89 (59). When these subjects approached puberty, two separate reference groups were recruited from the Trondheim SGA subpopulation: a) A group of term (> 37 weeks gestation) births with BW < 10 th percentile (SGA group; n = 54) and b) A group of term non-SGA births (controls; n = 66).…”

Section: Concerted Action With Local Academicsmentioning

confidence: 99%

The Scandinavian Small-for-Gestational Age (SGA) pregnancy and birth cohort – A source to continual insight into fetal growth restriction and long term physical and neurodevelopmental health in mother and offspring

Kjøbli¹,

Bach²,

Skogseth³

et al. 2016

Nor J Epidemiol

View full text Add to dashboard Cite

Human in utero growth restriction (IUGR) is associated with an increased risk for perinatal mortality and morbidity among newborns and infants. To pursue this challenge, a Request For Proposals (RFP) was issued in 1983 by The U.S. Epidemiology and Biometry Research Program at the National Institute of Child Health and Human Development (NICHD). A consortium was set up at the universities and university hospitals in Trondheim, Bergen (Norway) and Uppsala (Sweden) and was funded by the NICHD to conduct the Scandinavian Successive Small-for-Gestational Age (SGA) Pregnancy and Birth Outcome Study. The study design included a comprehensive biobank with maternal and cord serum samples, placental tissue, and a multitude of data collected from interviews, questionnaires, and clinical examinations.The SGA cohort study involved 6,354 Caucasian pregnant women in the three study sites who expected their second or third child from 1986-88. The study women were screened in early second trimester and mothers who had an increased risk to deliver a smaller than expected newborn were followed in detail through the second half of pregnancy and at birth. Selected children were screened several times through their first and up to five years of age. Moreover, a highly selected subgroup in Trondheim has been followed at 14, 19, and 26 years' age.Almost thirty years later, we have searched the body of scientific publications that originated from this cohort study in an attempt to assess if and to what extent the main aims and objectives were achieved and to summarize the overall outcomes. The SGA cohort has resulted in close to 100 published papers in peer reviewed journals and some 40 graduate and undergraduate degrees. Risk factors of SGA, like maternal smoking, low prepregnancy weight and education attainment, and a previous SGA birth outcome were confirmed. Conversely, no totally new and unknown risk factors were identified. Serial ultrasound measures have enabled a distinction between SGA with restricted and normal intrauterine growth, and has further indicated that being born SGA is mainly a problem in combination with IUGR. Further, the consequences of IUGR are more pronounced at adolescence and young adulthood than at five years of age.An increased understanding of the pathogenesis of different categories of growth restriction is essential to recognize and diagnose IUGR properly, and to reduce the perinatal mortality and morbidity from SGA. Moreover, SGA is a significant predictor at follow-up of the child. An up to date biobank has ensured the quality of data and biological samples, and has been crucial for the outcome of the entire SGA study. It continues to be a valuable resource in future research.This is an open access article distributed under the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

show abstract

Cerebral MRI findings in very-low-birth-weight and small-for-gestational-age children at 15 years of age

Abstract: Cerebral MRI pathology in white matter is a common finding in VLBW teenagers. The findings may indicate minor perinatal PVL with resulting loss of white-matter tissue and ventricular dilation.

Cited by 62 publications

References 37 publications

Multimodal image analysis of clinical influences on preterm brain development

Multimodal image analysis of clinical influences on preterm brain development

Selectively Reduced Posterior Corpus Callosum Size in a Population-Based Sample of Young Adults Born with Low Birth Weight

The Scandinavian Small-for-Gestational Age (SGA) pregnancy and birth cohort – A source to continual insight into fetal growth restriction and long term physical and neurodevelopmental health in mother and offspring

Contact Info

Product

Resources

About