Cerebral Oedema as a Consequence of Experimental Cervical Lymphatic Blockage

Harmine Action in Rats with Lymphostatic Encephalopathy

“…The formerly found differ ence, therefore, was interpreted as a consequence of vasodilatation. In dogs with lymphostatic encephalopathy Csanda et al (1968) never did find an extravasa tion of Evans blue into the brain tissue.…”

Increased Permeability of the Blood-Brain Barrier in Lymphostatic Encephalopathy

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It has been shown previously that ligation of the cervical lymphatics results in Lymphostatic Encephalopathy, characterized by a gross edema of the brain, accompanied by destruction of nerve cells and of the white matter [1,2,3].It has been shown, furthermore, that pathological alterations in this case are not restricted to the nervous tissue of the brain: also cerebral blood vessels are involved in the pathologic process (Lympho static Hemangiopathy [4]).

Based upon these observations, we decided to study the function of cerebral blood capillaries that exert signs of morphological altera tions.

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Kinins – Evidence for the Involvement in Lymphostatic Encephalopathy in Rats

“…There are some reasons that only local but not systemic kinin liberation could be maintained in the organism for a longer period of time [12], Obviously the significance of kinins is limited to local physiological and/or pathophysiological con ditions [5]. In numerous experiments the role of kinins in inflammation with increased vasopermeability has been studied [3,15].The lymphostatic encephalopathy of rats studied by Foldi and his col leagues [6,7,10] seems to be a model for a pathophysiological situation due to lymphogenic edema. Following surgical blockade of the cervical lymph vessels lymphostatic encephalopathy develops, which is charac-1 Parts of this work were presented at the International Symposium on Vasopeptides in Fiesole (Florence) 1971.…”