1993
DOI: 10.1016/0024-3205(93)90246-y
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Cerebrospinal fluid corticotropin-releasing hormone and ACTH, and peripherally circulating choline-containing phospholipid in senile dementia

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Cited by 11 publications
(5 citation statements)
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“…3 ) as well as in other cells types (data not shown) suggesting that LH, which is known to be increased in AD [ 10 ], is in fact able to bind to its receptor and initiate canonical signaling cascades in the hippocampus despite the non-gonadal nature of the tissue. It should be noted that follicle-stimulating hormone (FSH) and adrenocorticotropic hormone (ACTH) are also known to increase StAR expression ([ 31 ] and [ 32 ], respectively); however, we did not include the receptors for these hormones in this colocalization study as the FSH receptor has not been reported in the brain and ACTH is decreased in AD [ 33 , 34 ].…”
Section: Resultsmentioning
confidence: 99%
“…3 ) as well as in other cells types (data not shown) suggesting that LH, which is known to be increased in AD [ 10 ], is in fact able to bind to its receptor and initiate canonical signaling cascades in the hippocampus despite the non-gonadal nature of the tissue. It should be noted that follicle-stimulating hormone (FSH) and adrenocorticotropic hormone (ACTH) are also known to increase StAR expression ([ 31 ] and [ 32 ], respectively); however, we did not include the receptors for these hormones in this colocalization study as the FSH receptor has not been reported in the brain and ACTH is decreased in AD [ 33 , 34 ].…”
Section: Resultsmentioning
confidence: 99%
“…It has been reported that steroid hormones are reduced in Alzheimer's disease (27) and that this affects learning memory (28) and neurotransmitters in the brain (29). In this experiment, we measured testosterone and progesterone in the serum by an Enzyme Immunoassay kit (Cayman Chemical Company, Ann Arbor, MI, USA).…”
Section: Discussionmentioning
confidence: 99%
“…Nevertheless, these findings are not specific to Alzheimer's dementia. In fact, reduced levels of CRH in CSF were also demonstrated in patients with vascular dementia (139)(140)(141), and reduced CRH-like immunoreactivity at the level of the cerebral cortex level was also found in Parkinson's disease and progressive supranuclear palsy (143,145). Other alterations in the neuroendocrine system of AD patients have also been reported.…”
Section: Neuroendocrine Systemmentioning
confidence: 91%
“…The alteration of the HPA axis in AD patients is further supported by a significantly lower adrenocorticotropin hormone (ACTH) and cortisol release after administration of additional corticotropin-releasing hormone (CRH), as compared with the control group. In addition, it was demonstrated that CRH and ACTH levels are significantly reduced in the CSF of AD patients (138)(139)(140) in the absence of differences in plasma levels of CRH, ACTH, and cortisol (141). However, none of the patients showed evidence of pituitary-adrenal dysfunction, suggesting an involvement of extrahypothalamic CRH (138).…”
Section: Neuroendocrine Systemmentioning
confidence: 99%