Cerebrospinal fluid somatostatin in delirium

Koponen, Hannu; Stenbäck, Ulla; Mattila, Esa; Reinikainen, Kari; Riekkinen, Paavo

doi:10.1017/s003329170002420x

Cited by 16 publications

(7 citation statements)

References 34 publications

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“…Our findings suggest that positive effect of tacrine on cognitive abilities in AD may be partly mediated by direct or indirect somatostatinergic mechanisms. Although CSF SLI is reduced already in very early stages of AD (39), detection of CSF SLI cannot, however, be used as a diagnostic tool in AD because reduced levels of SLI have been reported in various neurological and psychiatric disorders (40,41,42).…”

Section: Discussionmentioning

confidence: 99%

Discrimination of Alzheimer patients responding to cholinesterase inhibitor therapy

Alhainen

Riekkinen

2009

Acta Neurologica Scandinavica

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We have studied whether it is possible to discriminate responders to tacrine treatment from patients nonresponsive to tacrine in Alzheimer's disease. The results indicate that mildly demented patients will most likely gain a benefit of tacrine treatment. Neuropsychological tests on attention and working memory after a single dose of tacrine might be useful as well as a single dose pharmaco‐EEG in discriminating responders to treatment.

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Section: Discussionmentioning

confidence: 99%

Discrimination of Alzheimer patients responding to cholinesterase inhibitor therapy

Alhainen

Riekkinen

2009

Acta Neurologica Scandinavica

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“…In a search for objectivity in this diagnosis, the authors who studied this disorder continue to point out the necessity to think about these different influences [16][17][18] . Like Freudenburg, when we have to make an assumption in a situation of high consensus, large experience and few obstacles, this assumption has less probability of error; conversely, with low consensus, little experience and many obstacles, the probability of error increases greatly 19 .…”

Section: Discussionmentioning

confidence: 99%

The diagnosis of delirium in 80 emergency unit patients

Neves

Sesso

Ferraz

et al. 1998

Arq. Neuro-Psiquiatr.

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-We evaluated the initial and final diagnosis of 80 patients with delirium arriving at the emergence unit of a university hospital in a large Brazilian city over a period of 30 months up to December 1991. The diagnosis was based on the DSM-IIIR criteria. Patients with a known history of head trauma or epileptic seizure and patients younger than 13 years were excluded. Only patients with a disease of up to 7 days were included.The patients were subdivided into four etiologic groups: vascular; associated with the use of alcohol; infectiousparasitic; miscellaneous.The results showed a rate of correct diagnosis ranging from 65 to 80% with the use of kappa test (standard good to excelent). Sensitivity, specificity, positive predictive and negative predictive values had results showing different conditions for initial diagnosis in each group. This study can help the initial diagnosis of delirium and the choice for diagnostic testing.KEY WORDS: delirium, diagnosis, acute confusional state. Delirium is a quite common syndrome but is often underestimated. The synonymy of this disease includes about thirty other terms. The first scientific description of delirium was probably made by Hippocrates. He used the word phrenitis, derived from phrenes, a word used to mean mind and also the muscle diaphragm. The word delirium was first used by Celsius, in the first century before Christ 1 . Great progress in the knowledge of acquired cognitive disturbances was first made in the nineteenth century. The linkage between brain and behavior was assumed to exist in a modern scientific meaning after the description of a left brain lesion associated with aphasia by Broca. Description of neurosyphilis, Huntington's chorea and Pick's disease were made by other authors. In 1906, Alzheimer described signs of neuronal degeneration in the brain of a woman with a progressive memory disorder 2 . Diagnóstico de delirium em 80 pacientes atendidos no pronto socorro

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“…The mechanisms whereby the various causative factors may induce delirium have not been fully worked out, but delirious patients have abnormalities in CSF neurotrans mitter levels [8,9], In addition, increased slow wave activity and disruption of the normal alpha rhythm in EEG has also been demonstrated in delirium [10].…”

Section: Discussionmentioning

confidence: 99%

Epileptic Attack, Delirium, and a Creutzfeldt-Jakob-Like Syndrome during Mianserin Treatment

Koponen¹,

Honkonen²,

Partanen³

et al. 1990

Neuropsychobiology

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Our report concerns 2 patients who developed delirium after an epileptic attack during mianserin treatment. In both cases the EEG showed a change with periodic sharp slow complexes similar to that seen in Creutzfeldt-Jakob disease. The symptoms subsided, however, and the EEG normalized after the antidepressant was discontinued, suggesting a noxious response to mianserin. If Creutzfeldt-Jakob-like changes in the EEG occur, the possible effect of antidepressant medication should be considered.

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Cerebrospinal fluid somatostatin in delirium

Cited by 16 publications

References 34 publications

Discrimination of Alzheimer patients responding to cholinesterase inhibitor therapy

Discrimination of Alzheimer patients responding to cholinesterase inhibitor therapy

The diagnosis of delirium in 80 emergency unit patients

Epileptic Attack, Delirium, and a Creutzfeldt-Jakob-Like Syndrome during Mianserin Treatment

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