Ceria Nanoparticles-Decorated Microcapsules as a Smart Drug Delivery/Protective System: Protection of Encapsulated <i>P. pyralis</i> Luciferase

Попов, А. И.; Popova, Nelli R.; Gould, David; Shcherbakov, A. B.; Sukhorukov, Gleb B.; Ivanov, V. K.

doi:10.1021/acsami.7b19658

Cited by 44 publications

(22 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2B). The obtained cerium(IV) oxide nanoparticles possessed catalase-like properties, as we showed earlier by the polarographic method [25], which confirms their antioxidant activity.…”

Section: Resultssupporting

confidence: 85%

Additive effects of green LED light and cerium oxide nanoparticles on the planarian’s regeneration

Ермаков¹,

Kamenskikh²,

Попов³

et al. 2021

Nanosystems: Phys. Chem. Math.

View full text Add to dashboard Cite

Nanotechnology makes it possible to design advanced materials being able to effectively modulate radiation effects on a cell, depending on the radiation intensity, wavelength, and type. Today, one of the most promising UV and X-ray protective biomaterials is nanocrystalline cerium oxide (CeO 2 ), which has a unique redox activity due to its surface reducibility. Meanwhile, the modulating properties of CeO 2 nanoparticles when the cells are exposed to visible light remain completely unexplored. Here, we analyzed the impact of CeO 2 nanoparticles on the process of planarian regeneration after exposure to low-intensity green LED light. It was found that a one-time exposure (10 or 25 min) of regenerating planarians with low-intensity green light reduced head blastema growth rate by up to 20%. At the same time, the preliminary treatment of planaria with CeO 2 nanoparticles in nanomolar concentrations (10 −11 M) ensures the restoration of the neoblasts activity and a significant acceleration of blastema regeneration. Thus, we have firstly demonstrated that the planarian regeneration process can be promoted by cerium oxide nanoparticles even under adverse action of low-intensity green light radiation.

show abstract

“…2B). The obtained cerium(IV) oxide nanoparticles possessed catalase-like properties, as we showed earlier by the polarographic method [25], which confirms their antioxidant activity.…”

Section: Resultssupporting

confidence: 85%

Additive effects of green LED light and cerium oxide nanoparticles on the planarian’s regeneration

Ермаков¹,

Kamenskikh²,

Попов³

et al. 2021

Nanosystems: Phys. Chem. Math.

View full text Add to dashboard Cite

show abstract

“…Recently, nanoceria (nano-CeO 2 ) has attracted remarkable attention owing to superb redox property and extensively utilization in biology including disease diagnosis, therapy, [9] and drug delivery. [10] Owing to reversible shift between Ce 3+ and Ce 4+ ions during the redox reaction, CeO 2 has the ability to simulate the behavior of superoxide dismutase (SOD) and catalase (CAT) via substantial surface oxygen vacancies, which can be applied to efficiently attenuate and eliminate ROS production. Recent years, increasing researches including us used nano-CeO 2 on inflammatory treatment and demonstrated that nano-CeO 2 could mitigate local inflammatory response by scavenging excessive ROS and playing an important role in suppressing M1 macrophage polarization through decreasing the expression of p65 to constrain the NF-κB signal pathway and decreasing the expression of TNF-a, IL-6, and IL-1β in macrophages.…”

Section: Introductionmentioning

confidence: 99%

Quercetin‐Loaded Ceria Nanocomposite Potentiate Dual‐Directional Immunoregulation via Macrophage Polarization against Periodontal Inflammation

Wang

Wan

et al. 2021

Small

112

View full text Add to dashboard Cite

ical reports demonstrated that severe periodontal disease is the sixth most prevalent disease, with a totaled prevalence of 11.2% and ≈743 million people affected worldwide, [2] accounting a major portion of the 442 billion USD year −1 cost for oral diseases. [3] Considering the pathogenesis of periodontitis, the exposure of periodontal tissues to the microorganisms would induce a defense response triggered by the host innate immune system, giving rise to the release of pro-inflammatory cytokines, thereby resulting in the damage of soft and hard tissues around the teeth.Current standard-of-care therapy aims at eliminating pathogenic microorganism and reducing the recolonization of bacteria by mechanical debridement. However, it is only partially effective for the majority of patients with periodontal disease, as the presence of bacterial was only regarded as the initiating factor. Once the host immune defense starts, it is hard to control the biological response to microbial challenge that can ultimately inflict damage upon the periodontal tissues. Therefore, it is highly desirable to develop host-modulation therapies for the treatment of periodontal disease. Macrophages represent the first line of host immune defense against periodontal pathogen infection both during the onset and resolution of inflammation. Macrophages can be classified into two groups based on the type of activation: pro-inflammatory M1 phenotype and anti-inflammatory M2 Macrophage polarization toward M1 phenotype (pro-inflammation) is closely associated with the destructive phase of periodontal inflammation. Nanoceria is verified to inhibit M1 polarization of macrophages by the favorable ability of reactive oxygen species (ROS) scavenging. However, the function of nanoceria on macrophage polarization toward M2 phenotype (anti-inflammation) in reparative phase of periodontal inflammation is quite limited. In this work, by introducing an antioxidant drug quercetin onto nano-octahedral ceria, synergistic and intense regulation of host immunity against periodontal disease is realized. Such nanocomposite can control the phenotypic switch of macrophages by not only inhibition of M1 polarization for suppressing the damage in the destructive phase but also promotion of M2 polarization for regenerating the surrounding tissues in reparative phase of periodontal disease. As-prepared nanocomposite can effectively increase the M2/M1 ratio of macrophage polarization in inflammatory cellular models by lipopolysaccharide stimulation. More importantly, the nanocomposite also exerts an improved therapeutic potential against local inflammation by significant downregulation of pro-inflammatory cytokines and upregulation of antiinflammatory cytokines in an animal model with periodontal inflammation. Therefore, this newly developed nanomedicine is efficient in ROS scavenging and driving pro-inflammatory macrophages to the anti-inflammatory phenotype to eliminate inflammation, thereby providing a promising candidate for treating periodontal inflammation.The ORCID i...

show abstract

“…The high surface area of ultra-small cerium oxide nanoparticles determines their active interaction with various ions and biomolecules, which, ultimately, can lead to the loss of the enzyme-like properties of the nanoparticles. However, the integration of nanoceria into the polyelectrolyte microcapsule can protect the encapsulated substance from negative external factors, as we have shown earlier [41]. The integration of nanoceria into the middle layer of the microcapsule maintains the possibility of access of various forms of ROS and free radicals to the surface of nanoparticles, due to the porous structure of the polyelectrolyte matrix.…”

Section: Introductionmentioning

confidence: 84%

Ceria-Containing Hybrid Multilayered Microcapsules for Enhanced Cellular Internalisation with High Radioprotection Efficiency

et al. 2020

Self Cite

View full text Add to dashboard Cite

Cerium oxide nanoparticles (nanoceria) are believed to be the most versatile nanozyme, showing great promise for biomedical applications. At the same time, the controlled intracellular delivery of nanoceria remains an unresolved problem. Here, we have demonstrated the radioprotective effect of polyelectrolyte microcapsules modified with cerium oxide nanoparticles, which provide controlled loading and intracellular release. The optimal (both safe and uptake efficient) concentrations of ceria-containing microcapsules for human mesenchymal stem cells range from 1:10 to 1:20 cell-to-capsules ratio. We have revealed the molecular mechanisms of nanoceria radioprotective action on mesenchymal stem cells by assessing the level of intracellular reactive oxygen species (ROS), as well as by a detailed 96-genes expression analysis, featuring genes responsible for oxidative stress, mitochondrial metabolism, apoptosis, inflammation etc. Hybrid ceria-containing microcapsules have been shown to provide an indirect genoprotective effect, reducing the number of cytogenetic damages in irradiated cells. These findings give new insight into cerium oxide nanoparticles’ protective action for living beings against ionising radiation.

show abstract

Ceria Nanoparticles-Decorated Microcapsules as a Smart Drug Delivery/Protective System: Protection of Encapsulated P. pyralis Luciferase

Cited by 44 publications

References 67 publications

Additive effects of green LED light and cerium oxide nanoparticles on the planarian’s regeneration

Additive effects of green LED light and cerium oxide nanoparticles on the planarian’s regeneration

Quercetin‐Loaded Ceria Nanocomposite Potentiate Dual‐Directional Immunoregulation via Macrophage Polarization against Periodontal Inflammation

Ceria-Containing Hybrid Multilayered Microcapsules for Enhanced Cellular Internalisation with High Radioprotection Efficiency

Contact Info

Product

Resources

About