Cervical Cancer Staging: A Resident’s Primer:<i>Women’s Imaging</i>

Raithatha, Anish; Papadopoulou, Ioanna; Stewart, Victoria; Barwick, Tara; Rockall, Andrea; Bharwani, Nishat

doi:10.1148/rg.2016150173

Cited by 10 publications

(4 citation statements)

References 3 publications

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“…Next, among cases in which a tumor was detected, ( b ) the presence or absence of parametrial invasion and ( c ) maximal tumor diameter were assessed. Parametrial invasion of the tumor was assumed to be positive if the reader found full-thickness cervical stromal invasion and one of the following additional imaging findings on T2WI: spiculated or nodular tumor-to-parametrial interface or encased parametrial vessel by the tumor 4,14 . The same definition was used for DWI and CE-T1WI.…”

Section: Methodsmentioning

confidence: 99%

“…Parametrial invasion of the tumor was assumed to be positive if the reader found full-thickness cervical stromal invasion and one of the following additional imaging findings on T2WI: spiculated or nodular tumor-to-parametrial interface or encased parametrial vessel by the tumor. 4,14 The same definition was used for DWI and CE-T1WI. Parametrial invasion was scored as follows: 1, definitely absent; 2, probably absent; 3, indeterminate (ie, impossible to evaluate); 4, probably present; and 5, definitely present.…”

Section: Imaging Analysismentioning

confidence: 99%

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Diagnostic Accuracy of Magnetic Resonance Imaging for International Federation of Gynecology and Obstetrics 2018 IB to IIB Cervical Cancer Staging: Comparison Among Magnetic Resonance Sequences and Pathologies

Matsumoto

Kido

Moribata

et al. 2021

J Comput Assist Tomogr

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Objective: This study aimed to investigate the most accurate magnetic resonance (MR) sequence for tumor detection, maximal tumor diameter, and parametrial invasion compared with histopathologic diagnoses.Methods: Fifty-one patients with International Federation of Gynecology and Obstetrics 2018 IB1 to IIB cervical cancer underwent preoperative MR imaging and surgical resection. Two radiologists independently evaluated the tumor detection, parametrial invasion, and tumor size in each of T2-weighted image, diffusion-weighted image, and contrast-enhanced T1-weighted image. Results obtained for squamous cell carcinoma (SCC) and adenocarcinoma were also compared. Results:Neither the tumor detection rate nor parametrial invasion was found to be significantly different among sequences. Tumor size assessment using MR imaging with pathology showed good correlation: r = 0.63-0.72. The adenocarcinoma size tended to be more underestimated than SCC in comparison with the pathologic specimen.Conclusions: Cervical cancer staging by MR images showed no significant difference among T2-weighted image, diffusion-weighted image, and contrast-enhanced T1-weighted image. Adenocarcinoma was prone to be measured as smaller than the pathologic specimen compared with SCC.

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Section: Methodsmentioning

confidence: 99%

Section: Imaging Analysismentioning

confidence: 99%

Diagnostic Accuracy of Magnetic Resonance Imaging for International Federation of Gynecology and Obstetrics 2018 IB to IIB Cervical Cancer Staging: Comparison Among Magnetic Resonance Sequences and Pathologies

Matsumoto

Kido

Moribata

et al. 2021

J Comput Assist Tomogr

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“…Отсутствие гипоинтенсивного ободка неизмененной стромы на Т2ВИ между опухолью и клетчаткой не всегда свидетельствует о распространении опухоли в параметрии. Чтобы констатировать параметральную инвазию, необходимо сочетание опухоли шейки матки, вовлекающей всю толщу стромы, с одним из следующих признаков [45,46]:…”

Section: роль мрт в диагностике стадировании и выборе тактики лечения...unclassified

Imaging of cervical cancer. Consensus of experts

Rubtsova,

Berezovskaia,

Bychenko

et al. 2023

Medicinskaâ vizualizaciâ

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The article offers the latest view on possibilities of diagnostic algorithm to identify cervical cancer (CC), one of the most incidental tumor of the woman’s reproductive system. The algorithm is described as a consensus of leading expert in imaging diagnostics, as well as oncogynecologysts, investigating diagnostic challenges and cervical cancer therapies. The article sets forth the principal trends in using imaging methods, their role and possibilities for staging CC, planning and assessing the efficacy of applied therapy, on-going surveillance over patients, who have undergone specialized anti-cancer treatment.

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“…PET/CT has a limited role in local primary staging [ 15 ]. The most important role is in the detection of distant metastasis and pathological lymph nodes with better performance than CT, especially for nonpathological enlarged lymph node metastases [ 16 , 17 ]. In patients with LACC, PET/CT is often used to plan the correct radiation therapy field.…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of posttreatment 18F-FDG PET/CT and predictors of metabolic response to therapy in patients with locally advanced cervical cancer treated with concomitant chemoradiation therapy: an analysis of intensity- and volume-based PET parameters

Lima

Matti

Vara

et al. 2018

Eur J Nucl Med Mol Imaging

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PurposeTo investigate the prognostic value of posttreatment 18F-FDG PET/CT in patients with locally advanced cervical cancer (LACC) treated with concomitant chemoradiation therapy (CCRT). The secondary aim was to assess the possible role of intensity-based and volume-based PET parameters including SUVmax, SUVmean, MTV and TLG, and clinical parameters including age, pathology, FIGO stage and nodal involvement as factors predicting response to treatment.MethodsThis retrospective study included 82 patients affected by LACC treated with CCRT. All patients underwent 18F-FDG PET/CT both before and after treatment. The posttreatment PET/CT scans were used to classify patients as complete metabolic responders (CMR) or non-complete metabolic responders (N-CMR) according to the EORTC criteria. Kaplan-Meier analysis was used to evaluate differences in overall survival (OS) between the CMR and N-CMR groups. Student’s t test, Pearson’s chi-squared test and logistic regression were used to investigate the possible value of PET and clinical parameters as predictors of metabolic response to therapy.ResultsKaplanMeier analysis showed a highly significant difference in OS between the CMR and N-CMR groups (log-rank test p < 0.0001). Significant independent predictors of response to therapy were MTV (p = 0.019, odds ratio = 1.015, 95% CI = 1.002–1.028, Nagelkerke R2 = 0.110), TLG (p = 0.045, odds ratio = 1.001, 95% CI = 1.000–1.002, Nagelkerke R2 = 0.081) and nodal involvement (p = 0.088, odds ratio = 2.361, 95% CI = 0.879–6.343, Nagelkerke R2 = 0.051).Conclusion18F-FDG PET/CT-based response assessment using the EORTC criteria reliably predicts OS in LACC patients treated with CCRT. In our cohort of patients, pretreatment MTV and TLG and nodal involvement were predictors of response to therapy. MTV was the best predictor of response. However, its additional risk value seems to be low (MTV odds ratio = 1.015).

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Cervical Cancer Staging: A Resident’s Primer:Women’s Imaging

Cited by 10 publications

References 3 publications

Diagnostic Accuracy of Magnetic Resonance Imaging for International Federation of Gynecology and Obstetrics 2018 IB to IIB Cervical Cancer Staging: Comparison Among Magnetic Resonance Sequences and Pathologies

Diagnostic Accuracy of Magnetic Resonance Imaging for International Federation of Gynecology and Obstetrics 2018 IB to IIB Cervical Cancer Staging: Comparison Among Magnetic Resonance Sequences and Pathologies

Imaging of cervical cancer. Consensus of experts

Prognostic value of posttreatment 18F-FDG PET/CT and predictors of metabolic response to therapy in patients with locally advanced cervical cancer treated with concomitant chemoradiation therapy: an analysis of intensity- and volume-based PET parameters

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