Chagasic meningoencephalitis in the immunodeficient

Lazo, Javier; Meneses, Antonio Carlos Oliveira; Rocha, Ademir; Ferreira, Marcelo Simão; Marquez, Jaime Olavo; Chapadeiro, E; Lopes, Edison Reis

doi:10.1590/s0004-282x1998000100015

Cited by 27 publications

(2 citation statements)

References 17 publications

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“…Trypanosoma brucei invades the CNS via the choroid plexus and the circumventricular organs (Masocha et al, 2007). Trypanosoma evansi was present in the brain of naturally-infected horses (Rodrigues et al, 2009) as well as Trypanosoma cruzi in immunodeficient humans (Javier et al, 1998). Leishmania on the other hand has been sporadically noticed in the CNS, using either histology or immunohistochemistry (Márquez et al, 2013;Nieto et al, 1996;Viñuelas et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

Leishmania infection and neuroinflammation: Specific chemokine profile and absence of parasites in the brain of naturally-infected dogs

Melo

Silva

Grano

et al. 2015

Journal of Neuroimmunology

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Visceral leishmaniasis is a chronic disease caused by Leishmania infantum. We aimed to detect the parasite in the brain of fifteen naturally-infected dogs using in situ hybridization and immunohistochemistry, and the gene expression of selected chemokines by RT-qPCR. We detected no parasite in the brain, but perivascular deposition of parasite DNA and IgG in the choroid plexus. We noticed up-regulation of CCL-3, CCL-4 and CCL-5, coherent with T lymphocyte accumulation, stating the brain as a pro-inflammatory environment. Indeed, not necessarily the parasite itself, but rather its DNA seems to act as a trigger to promote brain inflammation during visceral leishmaniasis.

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Section: Discussionmentioning

confidence: 99%

Leishmania infection and neuroinflammation: Specific chemokine profile and absence of parasites in the brain of naturally-infected dogs

Melo

Silva

Grano

et al. 2015

Journal of Neuroimmunology

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“…The appearance of bubbles or vesicles is frequent in cases of high parasitic load. Ultimately, asymptomatic status was achieved by the patient, with the occurrence of patent parasitaemia 93 .…”

Section: Regulations For Organ or Tissue Donations In Brazilmentioning

confidence: 99%

Guidelines for Trypanosoma cruzi-HIV Co-infection and other Immunosuppressive Conditions: Diagnosis, Treatment, Monitoring, and Implementation from the International Network of Care and Studies - 2023

Almeida,

Mendes,

Ramos Júnior

et al. 2023

Rev. Soc. Bras. Med. Trop.

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Since the Brazilian Ministry of Health's 1992 revision to the case definition of acquired immunodeficiency syndrome (AIDS), there has been scientific evidence showing that certain endemic infectious and parasitic processes, such as Chagas disease, visceral leishmaniasis, and paracoccidioidomycosis, can induce opportunistic behaviour in individuals with advanced Human Immunodeficiency Virus (HIV). This situation requires distinct clinical protocols within the healthcare network and epidemiological surveillance measures. These actions aim to incorporate clinical events as indications of AIDS.At the São Luiz-MA Congress of the Brazilian Society of Tropical Medicine in 2000, recommendations were given for the co-infection of Trypanosoma cruzi and HIV. These included defining the reactivation of Chagas disease as a definitive AIDS condition and making notification of reactivation cases compulsory. The creation of a working group to establish specific criteria for reactivation, constitution of a national network to provide care and study co-infection and reactivation, development of a manual for conduct in co-infection and reactivation, and formation of a national hemovigilance network dedicated to coinfection were discussed. This meeting served as a reference point for all future discussions in this field.The reconstruction of these perspectives over more than three decades has widened the possibilities for patients with Chagas disease to have greater access to the care network in the Unified Health System (SUS), taking into account the existing epidemiological changes 5 .

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Cerebral tumor-like American trypanosomiasis in acquired immunodeficiency syndrome

et al. 1999

Ann Neurol.

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Cerebral tumor‐like American trypanosomiasis (CTLAT) is an uncommon complication of Chagas' disease, observed only in immunosuppressed patients. We assessed 10 human immunodeficiency virus–positive patients with Chagas' disease who presented with CTLAT. All patients had neurological involvement and 6 developed intracranial hypertension. Neuroimaging studies showed supratentorial lesions in 9 patients, being single in 8. One case had infratentorial and supratentorial lesions. Low CD4+ cell counts were observed in all the cases and in 6 of them CTLAT was the first manifestation of acquired immunodeficiency syndrome. Serological tests for Chagas' disease were positive in 6 of 8 patients. Trypanosoma cruzi was identified in all brain specimens and in three cerebrospinal fluid samples. CTLAT should be considered in the differential diagnosis of intracranial mass lesions in human immunodeficiency virus–positive patients and should be added to the list of acquired immunodeficiency syndrome–defining illnesses. Ann Neurol 1999;45:403–406

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Chagasic meningoencephalitis in the immunodeficient

Cited by 27 publications

References 17 publications

Leishmania infection and neuroinflammation: Specific chemokine profile and absence of parasites in the brain of naturally-infected dogs

Leishmania infection and neuroinflammation: Specific chemokine profile and absence of parasites in the brain of naturally-infected dogs

Guidelines for Trypanosoma cruzi-HIV Co-infection and other Immunosuppressive Conditions: Diagnosis, Treatment, Monitoring, and Implementation from the International Network of Care and Studies - 2023

Cerebral tumor-like American trypanosomiasis in acquired immunodeficiency syndrome

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