Challenges in quantum dot-neuron active interfacing

Gómez, Natalia; Winter, Jessica O.; Shieh, Felice; Saunders, Aaron E.; Korgel, Brian A.; Schmidt, Christine E.

doi:10.1016/j.talanta.2005.06.041

Cited by 58 publications

(55 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A recent review shows that technological capabilities of nanomaterials are promising for solving many challenges that researchers are facing in developing artificial retinas and similar devices. [479] Activation of neurons via photostimulation is also relevant for standard NEs from the perspective of wireless operation of implantable devices using small hand-held sources of light. Despite the promise and importance, the actual amount of research activity in this area is not very high, probably as a result of the complexity of techniques and equipment necessary.…”

Section: Photoactive Nanostructures For the Neuron Interfacementioning

confidence: 99%

“…[479] These coatings can be both organic [480] or inorganic. [481][482][483][484][485] The most popular organic material for optical stimulation of neurons is bacteriorhodopsin, while inorganic coatings are typically made from standard doped silicon or other semiconductors.…”

Section: Photoactive Nanostructures For the Neuron Interfacementioning

confidence: 99%

“…[495] After that, however multiple challenges were found on the realization of this goal starting from cytotoxicity of NPs (see Section 3.1) and non-specific binding to rapid endocytosis of the attached NPs inside the cell. [479] One interesting example of quantum-dot based optically active interface is a hybrid bionanodevice made on the basis of HgTe NPs. These quantum dots absorb light and stimulate neural cells following a sequence of photochemical and charge-transfer reactions.…”

Section: Photoactive Nanostructures For the Neuron Interfacementioning

confidence: 99%

See 2 more Smart Citations

Nanomaterials for Neural Interfaces

et al. 2009

View full text Add to dashboard Cite

This review focuses on the application of nanomaterials for neural interfacing. The junction between nanotechnology and neural tissues can be particularly worthy of scientific attention for several reasons: (i) Neural cells are electroactive, and the electronic properties of nanostructures can be tailored to match the charge transport requirements of electrical cellular interfacing. (ii) The unique mechanical and chemical properties of nanomaterials are critical for integration with neural tissue as long‐term implants. (iii) Solutions to many critical problems in neural biology/medicine are limited by the availability of specialized materials. (iv) Neuronal stimulation is needed for a variety of common and severe health problems. This confluence of need, accumulated expertise, and potential impact on the well‐being of people suggests the potential of nanomaterials to revolutionize the field of neural interfacing. In this review, we begin with foundational topics, such as the current status of neural electrode (NE) technology, the key challenges facing the practical utilization of NEs, and the potential advantages of nanostructures as components of chronic implants. After that the detailed account of toxicology and biocompatibility of nanomaterials in respect to neural tissues is given. Next, we cover a variety of specific applications of nanoengineered devices, including drug delivery, imaging, topographic patterning, electrode design, nanoscale transistors for high‐resolution neural interfacing, and photoactivated interfaces. We also critically evaluate the specific properties of particular nanomaterials—including nanoparticles, nanowires, and carbon nanotubes—that can be taken advantage of in neuroprosthetic devices. The most promising future areas of research and practical device engineering are discussed as a conclusion to the review.

show abstract

Section: Photoactive Nanostructures For the Neuron Interfacementioning

confidence: 99%

Section: Photoactive Nanostructures For the Neuron Interfacementioning

confidence: 99%

Section: Photoactive Nanostructures For the Neuron Interfacementioning

confidence: 99%

See 1 more Smart Citation

Nanomaterials for Neural Interfaces

et al. 2009

View full text Add to dashboard Cite

show abstract

“…These studies demonstrated two main approaches to achieve light activation of neurons using QDs. The first approach is to directly wire QDs to the cell membrane, 147,148 as illustrated in Figure 3A. Although this scheme has so far failed to result in neuronal photostimulation, the prospects of establishing a very short distance QD-neuron coupling (ie, tens of nanometers) is very promising.…”

Section: Qdsmentioning

confidence: 99%

“…However, to achieve an active cell-QD interface, these thick coatings prevent efficient charge transfer, leading to decreased electric field generation. In a subsequent study, 148 uncoated, mercaptoacetic acid-capped CdS and cadmium telluride (CdTe) QDs were added to three different nerve cell culture types: SK-N-SH neuronal cell line, PC12 neuronal cell line, and rat neonatal cortical cells. Multiple challenges were identified, starting from cytotoxicity of NPs and nonspecific binding, to rapid endocytosis of the attached NPs inside the cell.…”

mentioning

confidence: 99%

Novel interfaces for light directed neuronal stimulation: advances and challenges

Bareket¹,

Hanein²

2014

IJN

View full text Add to dashboard Cite

Light activation of neurons is a growing field with applications ranging from basic investigation of neuronal systems to the development of new therapeutic methods such as artificial retina. Many recent studies currently explore novel methods for optical stimulation with temporal and spatial precision. Novel materials in particular provide an opportunity to enhance contemporary approaches. Here we review recent advances towards light directed interfaces for neuronal stimulation, focusing on state-of-the-art nanoengineered devices. In particular, we highlight challenges and prospects towards improved retinal prostheses.

show abstract

Microfluidics For Nanoneuroscience

Gross

Kartalov

2010

Microfluidic Devices in Nanotechnology

View full text Add to dashboard Cite

Challenges in quantum dot-neuron active interfacing

Cited by 58 publications

References 31 publications

Nanomaterials for Neural Interfaces

Nanomaterials for Neural Interfaces

Novel interfaces for light directed neuronal stimulation: advances and challenges

Microfluidics For Nanoneuroscience

Contact Info

Product

Resources

About