Change in Antibiotic Susceptibility Pattern of Clinical Bacterial Isolates from Two Hospitals in Dhaka, Bangladesh over a Period of Three Years

Fariba, Mahnaz Hossain; Sami, Abdullah Bashar; Bhattacharjee, Debanjan; Saha, Sajal Kumar; Bachar, Sitesh C.; Uddin, Mohammad Zashim; Kuddus, Ruhul

doi:10.9734/mrji/2017/39626

Cited by 1 publication

(10 citation statements)

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“…11 When an antibiotic is used improperly, then the corresponding bacterium became resistant to that antibiotic by developing resistant-gene and finally, this resistantgene is disseminated in the population in as a matter of time. 3,12 This increasing trend of resistant organisms causes more infectionassociated hospitalization, treatment failure, mortality and treatment cost. 8,13 In this study, the sensitivity patterns of meropenem, amikacin, ceftazidime and cefepime were significantly lower (all were found below 50% of the sensitivity level) than last resort polymyxin B and colistin to A. baumannii in every selected year.…”

Section: Discussionmentioning

confidence: 99%

“…2 Rate of infections among the hospitalized patients and in the community is very high, and still to date, antibiotics are sold more frequently without having a legal prescription and uses of antibiotics are found irrational in many cases. 3 Antimicrobial resistance (AMR) is a major concern not only for the local population of Dhaka city but also for the global public health due to the resistance-emergence. Inappropriate use, overuse and unjustified use of antibiotics are considered as the major causes of antibiotics becoming resistant to antibiotics.…”

Section: Introductionmentioning

confidence: 99%

“…Inappropriate use, overuse and unjustified use of antibiotics are considered as the major causes of antibiotics becoming resistant to antibiotics. 3,4 According to the World Health Organization (WHO), fast developing common bacterial resistance mechanisms to the available antibiotics is a threat for the global human health and day-by-day its severity is increasing, inconceivably. 4 In Bangladesh, availability of counterfeit antibiotics, incompleteness of individual dosing, injudicious antibiotic prescribing habits of the prescribers and inability of purchase the total prescribed dose of antibiotics are considered as the major key factors for enhancing the rate of antibiotics resistance in the community.…”

Section: Introductionmentioning

confidence: 99%

“…4 In Bangladesh, availability of counterfeit antibiotics, incompleteness of individual dosing, injudicious antibiotic prescribing habits of the prescribers and inability of purchase the total prescribed dose of antibiotics are considered as the major key factors for enhancing the rate of antibiotics resistance in the community. 3,5 Moreover, inappropriate use of antibiotics in the livestock has made this situation more complex nowadays. 6 In addition, day-by-day the resistance growing trend of the gram-negative bacteria against the few available potential antibiotics is now the major concern and this alarming situation is a vital threat for the global human health.…”

Section: Introductionmentioning

confidence: 99%

“…6 In addition, day-by-day the resistance growing trend of the gram-negative bacteria against the few available potential antibiotics is now the major concern and this alarming situation is a vital threat for the global human health. 3,6 In general, the most popular and potential antibiotics are meropenem, amikacin, ceftazidime, cefepime, polymyxin B and colistin (polymyxin E). 7,8 These antibiotics are mostly considered as the potential antibiotics when different types of infections are mostly caused by the most common gram-negative bacteria (GNB) including Escherichia coli, Klebsiella pneumonia, Acinetobacter baumannii and Pseudomonas aeruginosa.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

The resistance growing trend of common gramnegative bacteria to the potential antibiotics over three consecutive years: a single center experience in Bangladesh

Hasan¹,

Hosen²,

Bachar³

2019

PPIJ

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The increasing trend of antibiotic resistance is a global emergence. The susceptibility of the most common gram-negative bacteria (GNB) are reducing day-by-day to potential antibiotics as a result of different enzymatic and non-enzymatic resistancemechanisms of bacteria and disseminating the resistance-gene throughout the intra and inter-bacterial communities rapidly. The objective of this study was to evaluate the resistance developing trends of common GNB against the potential antibiotics over three consecutive years (2016, 2017 and 2018) in a single center of Bangladesh. The resistance pattern of meropenem, amikacin, ceftazidime and cefepime was fluctuated to Escherichia coli, Klebsiella pneumonia, Acinetobacter baumannii and Pseudomonas aeruginosa in year-to-year pattern and the overall sensitivity reducing trend was observed among those GNB to the selected potential antibiotics. Polymyxin B and colistin was found with relatively higher sensitivity trend to these GNB, but resistance to Klebsiella pneumonia and Acinetobacter baumannii was relatively higher. Ceftazidime was found always with a negative sensitivity trend to Acinetobacter baumannii and Pseudomonas aeruginosa, where others had positive sensitivity trend. Oppositely, amikacin and cefepime was found with highest positive sensitivity trend to P. aeruginosa (6.0 and 7.0, respectively). These resistance scenarios were found locally, but represented the severity of this crisis worldwide. Resistance developing trend is not limited to the few last resort antibiotics including polymyxin B and colistin. Awareness in antibiotics use, rational use and prescription of antibiotics, restriction of antibiotics in agriculture and livestock etc. are the urgent steps required to tackle this emergence.

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