Change of BNP between admission and discharge after ST-elevation myocardial infarction (Killip I) improves risk prediction of heart failure, death, and recurrent myocardial infarction compared to single isolated measurement in addition to the GRACE score

Carvalho, Luiz Sérgio F.; Bogniotti, Lauro Afonso Côrtes; Almeida, Osório L.R.; Silva, José C. Quinaglia e; Nadruz, Wilson; Coelho, Otávio Rizzi; Spósito, Andrei C.

doi:10.1177/2048872617753049

Cited by 27 publications

(24 citation statements)

References 28 publications

(33 reference statements)

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“…Patients demonstrating the biphasic pattern have a higher risk of LV remodelling and HF. 70,71 Additionally, premorbid N-terminal prohormone brain natriuretic peptide levels, as well as high-sensitivity troponin T levels measured at a median time of 6 years before MI, have also been associated with adverse events, including HF. 72…”

Section: Natriuretic Peptidesmentioning

confidence: 99%

Heart failure after myocardial infarction: incidence and predictors

et al. 2020

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Aims The aim of the present paper was to provide an up-to-date view on epidemiology and risk factors of heart failure (HF) development after myocardial infarction. Methods and results Based on literature review, several clinical risk factors and biochemical, genetic, and imaging biomarkers were identified to predict the risk of HF development after myocardial infarction. Conclusions Heart failure is still a frequent complication of myocardial infarction. Timely identification of subjects at risk for HF development using a multimodality approach, and early initiation of guideline-directed HF therapy in these patients, can decrease the HF burden.

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Section: Natriuretic Peptidesmentioning

confidence: 99%

Heart failure after myocardial infarction: incidence and predictors

et al. 2020

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“…For example, the Global Registry of Acute Coronary Event (GRACE) is recommended to predict mortality for patients with ACS by applying risk factors, cardiac biomarkers, and electrocardiograms. As summarized extensively, GRACE score's prognostic value is not perfect, and incremental effects after adding other laboratory parameters have been reported (40,41). For example, platelets play a pivotal role in the pathogenesis of all types of CAD.…”

Section: Discussionmentioning

confidence: 99%

The Prognostic Value of Reticulated Platelets in Patients With Coronary Artery Disease: A Systematic Review and Meta-Analysis

Zhao

Peng

Zhang

et al. 2020

Front. Cardiovasc. Med.

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Background: Reticulated platelets (RPs) represent the young population in the circulating platelet pool, indicating platelet turnover. Preliminary studies suggested circulating levels of RPs were associated with cardiovascular events (CVEs) in patients with coronary artery disease (CAD). Methods: This study systematically searched PubMed, Scopus, Embase, and Web of Science for eligible studies which reported RPs as a prognostic factor and the incidence of CVEs in patients with CAD. The risk estimates and 95% confidence intervals (95% CI) were analyzed for adjusted and unadjusted associations separately using random-effects model. Meta-regression and subgroup analysis were used to identify the source of heterogeneity. Funnel plots, Egger's test, and trim and fill methods were used to assess the publication bias. Results: A total of six cohort studies were included in this meta-analysis. Four studies were rated as high quality with the remaining rated as moderate quality. The funnel plot, Egger's test, and trim and fill method suggested the presence of publication bias. The pooled results indicated elevated RPs were associated with a higher risk of composite CVEs [risk ratio (RR), 2.26; 95% CI, 1.72-2.98, with little heterogeneity] and cardiovascular death (RR, 2.33; 95% CI, 1.66-3.28, with little heterogeneity). Based on results of separate meta-analysis, we found RPs might be a good predictor for revascularization but not for myocardial infarction or cerebrovascular events. After adjustment of conventional prognostic factors, the pooled result still suggested the prognostic value of RPs for composite CVEs (RR, 2.00; 95% CI, 1.30-3.08; p < 0.00001, with substantial heterogeneity). Subgroup analysis and meta-regression of adjusted risk estimates revealed that the number of adjustment factors might be the source heterogeneity. Conclusion: Circulating level of RPs might be a useful prognostic marker for CVEs in patients with CAD, even after adjustment of other prognostic factors.

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“…BNP or NT-proBNP is a significant predictor of prognosis in patients with MI. Admission plasma BNP and NT-proBNP concentrations are associated with all-cause mortality at long-term follow-up and with risk of hospitalizations with heart failure [9]. Plasma BNP/NT-proBNP concentration increases instantly after MI, and the grade of increase is related to the severity of ischemia [10].…”

Section: Discussionmentioning

confidence: 99%

Clinical Implications of Nt Probnp Level in Patients With Myocardial Infarction Complicated by Atrial Fibrillation

Tseluyko

Yakovleva

Salem

2019

Technology transfer: innovative solutions in medicine

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Our aim was to study the predictive value of NT proBNP regarding the risk of AF and clinical features in acute phase of ST-segment elevation MI (STEMI). Methods. We examined 56 patients with STEMI and AF who did undergo the primary PCI. 35 (62.5 %) of patients had the new-onset AF (group 1), 21 (37.5 %) had pre-existing AF (group 2). Control group consisted of 60 patients with STEMI without AF (group 3). Results. Group 3 patients were more likely to be smokers than patients in group 2. They had lower admission heart rate and glycemia, lower NT proBNP, higher hemoglobin and ejection fraction. Patients in group 1 were more likely to have anterior MI, left anterior descending artery as an infarction-related artery (IRA) and adverse cardiac events (MACEs). Patients in group 2 had higher left atrium end-systolic diameter and were more likely to have three-vessel injury. NT proBNP correlated positively with age, admission glycemia, mean PA pressure and negatively – with GFR. ROC analysis had shown the cut-off point of NT proBNP level for prediction of AF was >1050 pg/ml. Cut-off point for prediction of the risk of MACE in STEMI complicated with AF was >2189 pg/ml. Discussion. It was shown that NT proBNP is higher in STEMI patients who have AF. Increased NT proBNP is associated with the risk of adverse events in acute STEMI phase. NT proBNP level can be utilized as AF predictor in STEMI patients and as predictor of MACEs in patients with STEMI and AF.

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Change of BNP between admission and discharge after ST-elevation myocardial infarction (Killip I) improves risk prediction of heart failure, death, and recurrent myocardial infarction compared to single isolated measurement in addition to the GRACE score

Abstract: Only BNP-change following myocardial infarction was associated with poorer short- and long-term outcomes. BNP-change also improves risk reclassification in addition to the GRACE score.

Cited by 27 publications

References 28 publications

Heart failure after myocardial infarction: incidence and predictors

Heart failure after myocardial infarction: incidence and predictors

The Prognostic Value of Reticulated Platelets in Patients With Coronary Artery Disease: A Systematic Review and Meta-Analysis

Clinical Implications of Nt Probnp Level in Patients With Myocardial Infarction Complicated by Atrial Fibrillation

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