Changes in Body Composition, Hematologic Parameters, and Serum Biochemistry After Rapid Intravenous Infusion or Oral Intake of 2 Liters of 0.9 % Saline Solution in Young Healthy Volunteers: Randomized Crossover Study

Aguilar-Nascimento, José Eduardo de; Valente, A; Oliveira, Sérgio Souza; Hartmann, Arthur; Slhessarenko, Natasha

doi:10.1007/s00268-012-1756-0

Cited by 12 publications

(7 citation statements)

References 27 publications

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“…They concluded that with the use of restricted fluid resuscitation there was significant reduction of postoperative and cardiopulmonary complications, and of those related to wound healing, and they did not observe any possible adverse effect of the restriction system. Recently, a study from our group showed that oral replacement entails much less electrolyte changes than the intravenous one in healthy volunteers 20 . This study showed that it is possible to safely reduce fluid load administered postoperatively in oncological operations, thus reducing hospital costs.…”

Section: Results Results Results Resultsmentioning

confidence: 99%

Resultados clínicos antes e após a implantação do protocolo ACERTO

Costa¹,

Santos²,

Aguilar-Nascimento

2013

Rev. Col. Bras. Cir.

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OBJETIVO: Comparar os resultados clínicos pós-operatórios de pacientes submetidos à cirurgia oncológica no Hospital de Câncer de Mato Grosso antes e após a implantação do protocolo ACERTO. MÉTODOS: Foram prospectivamente observados 271 pacientes durante dois períodos: o primeiro, entre abril e maio de 2010 (n=101) formado por pacientes submetidos a condutas convencionais (Fase 1) e o segundo, entre setembro a outubro de 2010 (n=171), formado por pacientes submetidos a um novo protocolo de condutas peri-operatórias estabelecidas pelo projeto ACERTO (Fase 2). As variáveis observadas foram: tempo de jejum pré-operatório, reintrodução da dieta no período pós-operatório, volume de hidratação e tempo de internação. RESULTADOS: Na comparação entre os dois períodos, na Fase 2 houve uma queda de aproximadamente 50% do tempo de jejum pré-operatório (14,7 [4-48] horas vs 7,2 [1-48] horas, p<0,001), houve redução de aproximadamente 35% do volume de fluidos intravenosos no pós-operatório imediato (p<0,001), de 47% no 1º PO (p<0,001) e de 28% no 2º PO (p=0,04), sendo a redução global de 23% (p<0,001). Não houve diferença no tempo de internação pós-operatória entre as duas fases (3,9 [0-51] vs. 3,2 [0-15] dias; p=0.52). Entretanto, nos pacientes cujo tempo de jejum pré-operatório foi de até 5 horas houve redução de um dia de internação (3.8 [0-51] vs 2.5 [0-15] dias, p=0,03). CONCLUSÃO: A adoção das medidas do projeto ACERTO é factível e segura em doentes oncológicos. Após a implantação do protocolo ACERTO reduziu-se o volume de fluidos intravenosos e quando o jejum pré-operatório foi reduzido o tempo de internação foi menor.

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Section: Results Results Results Resultsmentioning

confidence: 99%

Resultados clínicos antes e após a implantação do protocolo ACERTO

Costa¹,

Santos²,

Aguilar-Nascimento

2013

Rev. Col. Bras. Cir.

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“…A previous work suggested that oral glucose intake inhibits hypothalamic neuronal activity than intravenous (IV) glucose administration more effectively [8], but oral intake saline results in minimal variations in serum albumin, hematocrit, and hemoglobin compared to IV infusion [9]. These studies indicated that, in addition to osmotic pressure and temperature mechanisms, the different autonomic responses of digestive tract might result in systemic regulation of peripheral blood perfusion.…”

Section: Introductionmentioning

confidence: 99%

Laterality of Blood Perfusion in the Lower Extremities after Drinking Saline at Different Temperatures

Jia

Wang

et al. 2021

Preprint

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Background: Skin blood flux (SkBF) changes caused by drinking cold water are generally associated with vagal tone and osmotic factors in the digestive system. However, the distribution and regulation of bilateral blood flow are not symmetrical but exhibit a certain laterality. The aim of this study was to analyze the laterality of skin blood flux after drinking saline (0.9%) at different temperatures by monitoring blood flux in the bilateral lower extremities.Methods: A total of 60 subjects were recruited for this study, and all subjects completed all measurements. Subjects were randomly divided into a 4 °C group, 10 °C group and 30 °C group. For every subject, skin blood perfusion of bilateral Zusanli acupoints (ST 36) was recorded simultaneously before and after drinking 500 ml of 0.9% saline using a PeriFlux System 5000. The electrogastrogram (EGG) was also monitored, and the dominant frequency of the EGG and heart rate variability were analyzed.Results: The results indicated that after drinking saline at different temperatures, the laterality index of skin blood flux at the lower extremities was different. Drinking 30 °C saline can increase the laterality index of the lower extremities. The results of wavelet analysis showed that the laterality index changes of skin blood flux were mainly reflected in the frequency interval V (0.4-1.6 Hz). Stimulation at 4 °C and 10 °C resulted in a decrease in the dominant frequency (DF) of the electrogastrogram and an increased root mean square of successive differences (RMSSD) of the RR interval. There was a weak negative correlation between the laterality index of frequency interval I or II and root mean square of successive differences.Conclusion: There was laterality of blood perfusion in the lower extremities after drinking saline at different temperatures.

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“…A previous study indicated that oral glucose intake inhibits hypothalamic neuronal activity more effectively than intravenous (IV) glucose administration 8 , but oral intake of 0.9% saline results in minimal variations in serum albumin, hemoglobin, and hematocrit compared to IV infusion 9 . These studies show that, in addition to temperature and osmotic pressure mechanisms, the digestive tract might have different autonomic responses, resulting in changes in peripheral blood perfusion in systemic regulation.…”

Section: Introductionmentioning

confidence: 99%

Laterality of Blood Perfusion in the Lower Extremities after Drinking Saline at Different Temperatures

Jia

Wang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Skin blood flux (SkBF) changes caused by drinking cold water are generally associated with vagal tone and osmotic factors in the digestive system. However, the distribution and regulation of bilateral blood flow are not symmetrical but exhibit a certain laterality. The aim of this study was to analyze the laterality of SkBF after drinking saline (0.9%) at different temperatures by monitoring blood flux in the bilateral lower extremities.Methods: A total of 60 subjects were recruited for this study, and all subjects completed all measurements. Subjects were randomly divided into a 4 °C group, 10 °C group and 30 °C group. For every subject, skin blood perfusion of bilateral Zusanli acupoints (ST 36) was recorded simultaneously before and after drinking 500 ml of 0.9% saline using a PeriFlux System 5000. The electrogastrogram (EGG) was also monitored, and the dominant frequency of the EGG and heart rate variability were analyzed.Results: The results indicated that after drinking saline at different temperatures, the laterality index of SkBF at the lower extremities was different. Drinking 30 °C saline can increase the laterality index of the lower extremities. Stimulation at 4 °C and 10 °C resulted in a decrease in the DF of the EGG and an increased RMSSD of the RR interval. Although this laterality is mainly contributed to by frequency interval V, there was a weak negative correlation between the laterality index of frequency interval I or II and RMSSD.Conclusion: There was laterality of blood perfusion in the lower extremities after drinking saline at different temperatures.

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Changes in Body Composition, Hematologic Parameters, and Serum Biochemistry After Rapid Intravenous Infusion or Oral Intake of 2 Liters of 0.9 % Saline Solution in Young Healthy Volunteers: Randomized Crossover Study

Abstract: Oral intake of 2 L of 0.9% saline results in minimal variations in serum albumin, hemoglobin, and hematocrit when compared to IV infusion of the same volume.

Cited by 12 publications

References 27 publications

Resultados clínicos antes e após a implantação do protocolo ACERTO

Resultados clínicos antes e após a implantação do protocolo ACERTO

Laterality of Blood Perfusion in the Lower Extremities after Drinking Saline at Different Temperatures

Laterality of Blood Perfusion in the Lower Extremities after Drinking Saline at Different Temperatures

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