Changes in cell adhesion and extracellular matrix molecules in spontaneous spinal neural tube defects in avian embryos

Newgreen, Donald F.; Kerr, Richard; Minichiello, J.; Warren, Nicholas J.

doi:10.1002/(sici)1096-9926(199703)55:3<195::aid-tera4>3.0.co;2-1

Cited by 21 publications

(8 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, this does not necessarily mean that any failure in neural tube closure may not impact on EMT itself. 39,57,58 NC progenitors are integrated in the dorsal neural tube after closure. They do not yet constitute, as in the head, a separate cell population and they cannot be discriminated morphologically from the other neural epithelial cells.…”

Section: The Neural Crest a Cell Population Issued By An Emtmentioning

confidence: 99%

Diversity in the molecular and cellular strategies of epithelium-to-mesenchyme transitions: Insights from the neural crest

Duband

2010

Cell Adhesion & Migration

View full text Add to dashboard Cite

Section: The Neural Crest a Cell Population Issued By An Emtmentioning

confidence: 99%

Diversity in the molecular and cellular strategies of epithelium-to-mesenchyme transitions: Insights from the neural crest

Duband

2010

Cell Adhesion & Migration

View full text Add to dashboard Cite

“…Since then, HNK-1 and NC-1 have been frequently used to identify neural crest-derived cells within the embryonic gut, primarily of chick and quail embryos (Figs. 3A,4;Tucker et al, 1986;Pomeranz and Gershon, 1990;Epstein et al, 1991;Newgreen et al, 1996Newgreen et al, , 1997. HNK-1 and NC-1 also bind to neural crest-derived cells in a range of species including rat (Fig.…”

Section: Phenotype Of Enteric Neuron Precursors Prior To Entering Thementioning

confidence: 99%

“…Vagally-derived HNK-1/NC-1-positive cells colonize the embryonic chick and quail gut in a rostral-to-caudal wave ( Fig. 4; Tucker et al, 1986;Epstein et al, 1991;Newgreen et al, 1997;Schiltz et al, 1999), and it is assumed that all undifferentiated neural crest-derived cells in the chick gut are HNK-1-postive.…”

Section: Phenotype Of Neural Crest-derived Cells Within the Gut Wallmentioning

confidence: 99%

Enteric neural crest-derived cells: Origin, identification, migration, and differentiation

2001

View full text Add to dashboard Cite

“…N-cadherin is expressed by embryonic neural and mesodermal epithelia (Hatta et al, 1987), and in prostate carcinoma studies it has been associated with progression, where it is expressed reciprocally with E-cadherin Tomita et al, 2000). In the embryo, however, E-and N-cadherins can be coexpressed, with pathologic variations in the extent of coexpression (Newgreen et al, 1997). The actin cytoskeleton is also connected to the ECM through transmembrane adhesion molecules such as integrins, via linker and associated signaling molecules, and thus spatial concordance can be seen between the actin meshwork and ECM molecules (Parsons et al, 2000;Turner, 2000).…”

mentioning

confidence: 99%

Epidermal Growth Factor-Induced Epithelio-Mesenchymal Transition in Human Breast Carcinoma Cells

Ackland

Newgreen

Fridman

et al. 2003

Laboratory Investigation

125

117

View full text Add to dashboard Cite

SUMMARY: PMC42-LA cells display an epithelial phenotype: the cells congregate into pavement epithelial sheets in which E-cadherin and ␤-catenin are localized at cell-cell borders. They abundantly express cytokeratins, although 5% to 10% of the cells also express the mesenchymal marker vimentin. Stimulation of PMC42-LA cells with epidermal growth factor (EGF) leads to epithelio-mesenchymal transition-like changes including up-regulation of vimentin and down-regulation of E-cadherin. Vimentin expression is seen in virtually all cells, and this increase is abrogated by treatment of cells with an EGF receptor antagonist. The expression of the mesenchyme-associated extracellular matrix molecules fibronectin and chondroitin sulfate proteoglycan also increase in the presence of EGF. PMC42-LA cells adhere rapidly to collagen I, collagen IV, and laminin-1 substrates and markedly more slowly to fibronectin and vitronectin. EGF increases the speed of cell adhesion to most of these extracellular matrix molecules without altering the order of adhesive preference. EGF also caused a time-dependent increase in the motility of PMC42-LA cells, commensurate with the degree of vimentin staining. The increase in motility was at least partly chemokinetic, because it was evident both with and without chemoattractive stimuli. Although E-cadherin staining at cell-cell junctions disappeared in response to EGF, ␤-catenin persisted at the cell periphery. Further analysis revealed that N-cadherin was present at the cell-cell junctions of untreated cells and that expression was increased after EGF treatment. N-and E-cadherin are not usually coexpressed in human carcinoma cell lines but can be coexpressed in embryonic tissues, and this may signify an epithelial cell population prone to epithelio-mesenchymal-like responses. (Lab Invest 2003, 83:435-448).

show abstract

Changes in cell adhesion and extracellular matrix molecules in spontaneous spinal neural tube defects in avian embryos

Cited by 21 publications

References 43 publications

Diversity in the molecular and cellular strategies of epithelium-to-mesenchyme transitions: Insights from the neural crest

Diversity in the molecular and cellular strategies of epithelium-to-mesenchyme transitions: Insights from the neural crest

Enteric neural crest-derived cells: Origin, identification, migration, and differentiation

Epidermal Growth Factor-Induced Epithelio-Mesenchymal Transition in Human Breast Carcinoma Cells

Contact Info

Product

Resources

About