Changes in lung function and respiratory symptoms during pesticide spraying season among male sprayers

Sapbamrer, Ratana; Thongtip, Sakesun; Khacha-ananda, Supakit; Sittitoon, Nalin; Wunnapuk, Klintean

doi:10.1080/19338244.2019.1577208

Cited by 14 publications

(15 citation statements)

References 37 publications

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“…This finding is consistent with a study carried out in South Korea which found that farmers who used paraquat herbicide had decreased FVC and FEV 1 (β = -5.20, p < 0.001 for FVC; β = -1.89, p = 0.010 for FEV 1 ) [ 46 ]. These findings also concur with a previous study in Thailand which found that the values of FVC%, FEV 1 %, and PEFR% after spraying pesticides were statistically significantly lower than before spraying pesticides ( p = 0.012 for FVC%; p = 0.02 for FEV 1 %; p = 0.022 for PEFR%) [ 47 ]. Similarly, a study in India found that the value of FEV 1 after spraying of pesticides was statistically significantly lower than before spraying of pesticides ( p < 0.05) [ 35 ].…”

Section: Discussionsupporting

confidence: 92%

Effects of exposure to glyphosate on oxidative stress, inflammation, and lung function in maize farmers, Northern Thailand

et al. 2022

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Background Glyphosate is a herbicide which is commonly used in agricultural areas. However, previous studies on glyphosate exposure in farmers and their health are still scarce. Methods A longitudinal pre-post study was performed among maize farmers. Information from questionnaires, urine and blood samples, and lung function were collected a day before and a day after glyphosate application in the morning. The urine samples were analyzed using liquid chromatography-tandem mass spectrometry to detect glyphosate levels. Serum samples were analyzed to detect malondialdehyde (MDA), glutathione (GHS), and C-reactive protein (CRP) levels using thiobarbituric acid, dithiobisnitrobenzoic acid, and nephelometry, respectively. Lung function performances were measured using a spirometer. Results A total of 180 maize farmers met the study inclusion criteria. After glyphosate application, it was found that increased urinary glyphosate levels contributed to increased serum MDA (β = 0.024, 95% CI = 0.000, 0.0047) and decreased serum GHS (β = -0.022, 95% CI = -0.037, -0.007), FEV1 (β = -0.134, 95% CI = -0.168, -0.100), FEV1/FVC (β = -0.062, 95% CI = -0.082, -0.042) and PEF (β = -0.952, 95% CI = -1.169, -0.735). Conclusions Exposure to glyphosate during glyphosate application had significant effects on oxidative stress and lung function in maize farmers.

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Section: Discussionsupporting

confidence: 92%

Effects of exposure to glyphosate on oxidative stress, inflammation, and lung function in maize farmers, Northern Thailand

et al. 2022

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“…Moreover, the total residues of the target compounds in earthworms in Sn soil were much higher than those in Sa soil, which showed that the existence of the organic matter had strongly influenced the elimination of pesticides. The relevant studies also revealed that the natural soil with higher adsorptive capacity and more excessive organic matter might increase the analyte accumulation by earthworms while decreasing their elimination …”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…The relevant studies also revealed that the natural soil with higher adsorptive capacity and more excessive organic matter might increase the analyte accumulation by earthworms while decreasing their elimination. 32 3.3. Stereoselective Degradation in Cabbage, Chinese Cabbage, and Strawberry.…”

Section: Stereoselective Degradation In Soil Andmentioning

confidence: 99%

“…It has been reported that the respiratory inhalation caused during agricultural spray would lead to the exposure of respiratory epithelial cells to very high concentrations of the pesticides and might impair lung function and develop further respiratory disease and related complications. 32 Therefore, we examined the enantioselective effect of BPMC in both the human fetal lung fibroblast cells (MRC5) and the non-smallcell lung cancer cells (A549). As shown in Figure 4C,D, R-(−)-BPMC-, S-(+)-BPMC-, and rac-BPMC-treated cells with the concentration of 0.5 mmol/L could significantly decrease the viabilities of A549 and MRC5 cells, with R-(−)-BPMC showing the most potent cytotoxic effect, as compared with that in the control group.…”

Section: Stereoselective Degradation In Soil Andmentioning

confidence: 99%

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Systemic Stereoselectivity Study of Fenobucarb: Environmental Behaviors in Greenhouse Vegetables, Fruits, Earthworms, and Soils and Its Cytotoxicity

Zhang

et al. 2022

J. Agric. Food Chem.

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Fenobucarb (2-sec-butylphenyl methylcarbamate, BPMC) is a potent carbamate pesticide with high insecticidal activity. In this study, the enantioselective accumulation of BPMC in earthworms (Eisenia foetida) and dissipation in cabbage, Chinese cabbage, strawberry, and soils were investigated. The samples were prepared using the QuEChERS method and analyzed using fast and sensitive chiral high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) analysis. The stereoselective accumulation of BPMC enantiomers revealed that S-(+)-BPMC was preferentially accumulated in earthworms rather than its antipode. However, the dissipation studies showed that S-(+)-BPMC degraded faster than the R-(−)-isomer in cabbage, Chinese cabbage, strawberry, and soils. Furthermore, the cytotoxic effect of BPMC enantiomers toward PC12 and N9 neuronal, A549 lung cancer, and MRC5 lung fibroblast cell lines was evaluated using an 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Compared with R-(−)- and rac-isomers, S-(+)-BPMC exhibited lower cytotoxicity in neuronal cells and a weaker proliferating effect on lung cancer and lung fibroblast cells. Altogether, the findings suggest the use of the pure S-(+)-enantiomer in agricultural management rather than the use of the racemate or the R-(−)-isomer, which might reduce the environmental risk.

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Characterizing country-specific human and ecosystem health impact and damage cost of agricultural pesticides: the case for Thailand

Mankong

Fantke

Phenrat

et al. 2022

Int J Life Cycle Assess

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Purpose Existing emission and toxicity characterization models in life cycle assessment are currently not suitable for assessing pesticide-related impacts of crop cultivation in tropical regions. This study aims to parameterize the scientific consensus model USEtox for Thai environments to derive toxicity characterization factors of pesticide emissions from agricultural systems in Thailand. Potential human toxicity and ecotoxicity impacts and related damage costs of pesticides used on nine crops cultivated in Thailand are quantified. Methods Considering country-specific conditions, USEtox was adapted by applying the landscape and consumption parameters specific to Thailand. Related Thai-specific characterization factors of identified pesticides used in Thai agriculture were quantified. Four emission inventory models were applied to determine pesticide emission fractions in different environmental compartments. The consistent combination of pesticide emission mass and associated characterization factors yielded potential toxicity impact scores. Pesticide impact-related damage costs (external costs) on human health and ecosystem quality were quantified using valuation factors for Thailand. The crops with the highest total damage costs were selected and compared with the annual net incomes of the respective crop production systems. Results and discussion Pesticide toxicity impacts assessed by using Thai-specific factors were different from the use of global average factors ranging from 1 to 169% (human toxicity) and from 0.1 to 3587% (ecotoxicity). Our results indicated the variability in impact scores influenced by emission modeling choices. Following PestLCI consensus emission estimation model, mango cultivation showed the highest human toxicity impacts of 0.07 DALY/ha, resulting in high human health damage costs mainly caused by Propineb (93%). Rice cultivation with a dry direct-seeded system exhibited the highest ecotoxicity impacts (3934 PDF m3 day/ha) and associated damage costs mainly caused by Oxadiazon (92%). Pesticides used in cultivation of nine crops resulted in total damage costs of 7188 and 3.01 million THB/crop-year for human health and ecotoxicity, respectively. Mango and rice production accounted for 70% and 17% of the total damage costs, which were 36% and 20% of the respective crops’ annual net income. Conclusions Our study illustrates the ranking of pesticides applied throughout the crop calendar causing toxicological impact and related damage costs on human health and ecosystem quality. This helps identify crops and the main contributors to pesticide-related toxicity impacts in Thailand. Our study highlights the need for proper emission quantification and for the use of characterization factors locally parameterized to increase accuracy. Our results will be useful for future improvement toward more sustainable pesticide use. Graphical abstract

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Changes in lung function and respiratory symptoms during pesticide spraying season among male sprayers

Cited by 14 publications

References 37 publications

Effects of exposure to glyphosate on oxidative stress, inflammation, and lung function in maize farmers, Northern Thailand

Effects of exposure to glyphosate on oxidative stress, inflammation, and lung function in maize farmers, Northern Thailand

Systemic Stereoselectivity Study of Fenobucarb: Environmental Behaviors in Greenhouse Vegetables, Fruits, Earthworms, and Soils and Its Cytotoxicity

Characterizing country-specific human and ecosystem health impact and damage cost of agricultural pesticides: the case for Thailand

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